Kinuko Ohneda
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View article: Additive associations of variants at the expression quantitative trait loci of <i>TFR2</i> and <i>EPO</i> in a linkage disequilibrium block with hypochromic erythropoiesis
Additive associations of variants at the expression quantitative trait loci of <i>TFR2</i> and <i>EPO</i> in a linkage disequilibrium block with hypochromic erythropoiesis Open
Reciprocal interactions between iron metabolism and erythropoiesis are well established in patients and animal models under stress. To elucidate this interplay in healthy individuals, we conducted a genome-wide association study (GWAS) inv…
View article: Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update
Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update Open
View article: Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study
Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study Open
Several metabolites were found to mediate the association between PRS and incident T2DM. These findings may contribute to a better understanding of the metabolic pathways involved in genetic susceptibility to T2DM.
View article: Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis
Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis Open
Background A method for predicting ulcerative colitis (UC) onset has not been established. Serum autoantibodies have been suggested as potential predictive biomarkers for UC onset. We aimed to validate the risks associated with serological…
View article: Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study
Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study Open
Breast milk lipids (FAHFA, ChE) associated with the AR status of children, indicating the potential to regulate a child's adiposity and possible metabolic disorders in adulthood.
View article: Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan
Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan Open
View article: Absolute quantification of eight human milk oligosaccharides in breast milk to evaluate their concentration profiles and associations with infants’ neurodevelopmental outcomes
Absolute quantification of eight human milk oligosaccharides in breast milk to evaluate their concentration profiles and associations with infants’ neurodevelopmental outcomes Open
Human milk oligosaccharides (HMOs) have been positively associated with child neurodevelopment in some cohort studies. However, there is a lack of consistency in the association between HMOs and benefits to infants’ brains. Moreover, the q…
View article: Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals
Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals Open
Whole blood transcriptome analysis is a valuable approachin medical research, primarily due to the ease of sample collection and the richness of the information obtained. Since the expression profile of individual genes in the analysis is …
View article: Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study Open
(1) Background: Breast milk is the only source of nutrition for breastfed infants, but few studies have examined the relationship between breast milk micronutrients and infant neurodevelopmental outcome in exclusively breastfed infants. Th…
View article: The Il6 -39 kb enhancer containing clustered GATA2- and PU.1-binding sites is essential for Il6 expression in murine mast cells
The Il6 -39 kb enhancer containing clustered GATA2- and PU.1-binding sites is essential for Il6 expression in murine mast cells Open
Mast cells serve as a first-line defense of innate immunity. Interleukin-6 (IL-6) induced by bacterial lipopolysaccharide (LPS) in mast cells plays a crucial role in antibacterial protection. The zinc finger transcription factor GATA2 coop…
View article: A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants
A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants Open
These results collectively suggest possible benefits of returning preemptive PGx information to ostensibly healthy cohort participants in a research setting.
View article: Review of: "On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation"
Review of: "On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation" Open
View article: Rejuvenation of mesenchymal stem cells by extracellular vesicles inhibits the elevation of reactive oxygen species
Rejuvenation of mesenchymal stem cells by extracellular vesicles inhibits the elevation of reactive oxygen species Open
Aging induces numerous cellular disorders, such as the elevation of reactive oxygen species (ROS), in a number type of cells, including mesenchymal stem cells (MSCs). However, the correlation of ROS and impaired healing abilities as well a…
View article: Mouse Tryptase Gene Expression is Coordinately Regulated by GATA1 and GATA2 in Bone Marrow-Derived Mast Cells
Mouse Tryptase Gene Expression is Coordinately Regulated by GATA1 and GATA2 in Bone Marrow-Derived Mast Cells Open
Mast cell tryptases have crucial roles in allergic and inflammatory diseases. The mouse tryptase genes represent a cluster of loci on chromosome 16p3.3. While their functional studies have been extensively performed, transcriptional regula…
View article: GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse <i>Ms4a2</i> Gene, Encoding FcεRI<i>β</i>, through Distinct Mechanisms
GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse <i>Ms4a2</i> Gene, Encoding FcεRI<i>β</i>, through Distinct Mechanisms Open
GATA factors GATA1 and GATA2 and ETS factor PU.1 are known to function antagonistically during hematopoietic development. In mouse mast cells, however, these factors are coexpressed and activate the expression of the Ms4a2 gene enco…
View article: Increased Expression of EGR-1 in Diabetic Human Adipose Tissue-Derived Mesenchymal Stem Cells Reduces Their Wound Healing Capacity
Increased Expression of EGR-1 in Diabetic Human Adipose Tissue-Derived Mesenchymal Stem Cells Reduces Their Wound Healing Capacity Open
The prevalence of type 2 diabetes mellitus (T2DM), which leads to diabetic complications, has been increasing worldwide. The possible applications of T2DM-derived stem cells in cell therapy are limited because their characteristics are sti…
View article: A Chemokine Receptor, CXCR4, Which Is Regulated by Hypoxia-Inducible Factor 2α, Is Crucial for Functional Endothelial Progenitor Cells Migration to Ischemic Tissue and Wound Repair
A Chemokine Receptor, CXCR4, Which Is Regulated by Hypoxia-Inducible Factor 2α, Is Crucial for Functional Endothelial Progenitor Cells Migration to Ischemic Tissue and Wound Repair Open
Endothelial progenitor cells (EPCs) have the ability to form new blood vessels and protect ischemic tissues from damage. We previously reported that EPCs with low activity of aldehyde dehydrogenase (Alde-Low EPCs) possess the greater abili…
View article: GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow
GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow Open
Key Points Mouse BM-derived mast cells can dedifferentiate into immature myeloid-like cells after the deletion of the GATA2 DNA binding domain. Increased expression of C/EBPα is critical for the dedifferentiation of GATA2-deficient mast ce…
View article: The Human <i>GATA1</i> Gene Retains a 5′ Insulator That Maintains Chromosomal Architecture and <i>GATA1</i> Expression Levels in Splenic Erythroblasts
The Human <i>GATA1</i> Gene Retains a 5′ Insulator That Maintains Chromosomal Architecture and <i>GATA1</i> Expression Levels in Splenic Erythroblasts Open
GATA1 is a key transcription factor for erythropoiesis. GATA1 gene expression is strictly regulated at the transcriptional level. While the regulatory mechanisms governing mouse Gata1 (mGata1) gene expression have been studied extensively,…
View article: Hypoxia‐inducible factor‐3α promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the <scp>VE</scp>‐cadherin gene
Hypoxia‐inducible factor‐3α promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the <span>VE</span>‐cadherin gene Open
The variants of the hypoxia‐inducible factor‐3α gene HIF ‐3α and NEPAS are known to repress the transcriptional activities driven by HIF ‐1α and HIF ‐2α. Although NEPAS has been shown to play an important role in vascular remodeling during…