Kira Eilers
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View article: The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture
The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture Open
Bacterial lifestyles depend on conditions encountered during colonization. The transition between planktonic and biofilm growth is dependent on the intracellular second messenger c-di-GMP. High c-di-GMP levels driven by diguanylate cyclase…
View article: Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa
Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa Open
Chaperone-Usher Pathway (CUP) pili are major adhesins in Gram-negative bacteria, mediating bacterial adherence to biotic and abiotic surfaces. While classical CUP pili have been extensively characterized, little is known about so-called ar…
View article: Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes
Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes Open
Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in a multitude of niches as well as thrive within many different hosts. This versatility lies within its large genome of ca. 6 Mbp and a tight control in…
View article: Architecture of the biofilm-associated archaic CupE pilus from<i>Pseudomonas aeruginosa</i>
Architecture of the biofilm-associated archaic CupE pilus from<i>Pseudomonas aeruginosa</i> Open
Chaperone-Usher Pathway (CUP) pili are major adhesins in Gram-negative bacteria, mediating bacterial adherence to biotic and abiotic surfaces. While classical CUP pili have been extensively characterized, little is known about so-called ar…
View article: Dual role of a (p)ppGpp‐ and (p)ppApp‐degrading enzyme in biofilm formation and interbacterial antagonism
Dual role of a (p)ppGpp‐ and (p)ppApp‐degrading enzyme in biofilm formation and interbacterial antagonism Open
The guanosine nucleotide‐based second messengers ppGpp and pppGpp (collectively: (p)ppGpp) enable adaptation of microorganisms to environmental changes and stress conditions. In contrast, the closely related adenosine nucleotides (p)ppApp …
View article: GO analysis of biological processes enriched in control and infected mice
GO analysis of biological processes enriched in control and infected mice Open
Table of all data exported for the GO analysis of biological processes enriched in samples sequenced from control and infected mice from the paper Haltalli et al, Manipulating niche composition limits damage to haematopoietic stem cells du…
View article: Cyclic di‐GMP inactivates T6SS and T4SS activity in <i>Agrobacterium tumefaciens</i>
Cyclic di‐GMP inactivates T6SS and T4SS activity in <i>Agrobacterium tumefaciens</i> Open
Summary The Type VI secretion system (T6SS) is a bacterial nanomachine that delivers effector proteins into prokaryotic and eukaryotic preys. This secretion system has emerged as a key player in regulating the microbial diversity in a popu…
View article: Malaria-induced remodelling of the bone marrow microenvironment mediates loss of haematopoietic stem cell function
Malaria-induced remodelling of the bone marrow microenvironment mediates loss of haematopoietic stem cell function Open
Severe infections are a major source of stress on haematopoiesis, where consequences for haematopoietic stem cells (HSCs) have only recently started to emerge. HSC function critically depends on the integrity of complex bone marrow niches,…