Kira L. Lathrop
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View article: Characterization of zebrafish nucleus pulposus in development and aging: A fish model for probing human intervertebral disc degeneration and regeneration
Characterization of zebrafish nucleus pulposus in development and aging: A fish model for probing human intervertebral disc degeneration and regeneration Open
Intervertebral disc (IVD) degeneration (IDD) contributes to low back and neck pain. The nucleus pulposus (NP) of the IVD is usually degenerated first in age-related IDD. Addressing NP degeneration remains challenging due to insufficient un…
View article: Activated <scp>mTOR</scp> Signaling in the <scp>RPE</scp> Drives <scp>EMT</scp>, Autophagy, and Metabolic Disruption, Resulting in <scp>AMD</scp>‐Like Pathology in Mice
Activated <span>mTOR</span> Signaling in the <span>RPE</span> Drives <span>EMT</span>, Autophagy, and Metabolic Disruption, Resulting in <span>AMD</span>‐Like Pathology in Mice Open
The mechanistic target of rapamycin (mTOR) complexes 1 and 2 (mTORC1/2) are crucial for various physiological functions. Although the role of mTORC1 in retinal pigmented epithelium (RPE) homeostasis and age–related macular degeneration (AM…
View article: JP4-039, a Mitochondria-Targeted Nitroxide, Mitigates the Effect of Apoptosis and Inflammatory Cell Migration in the Irradiated Mouse Retina
JP4-039, a Mitochondria-Targeted Nitroxide, Mitigates the Effect of Apoptosis and Inflammatory Cell Migration in the Irradiated Mouse Retina Open
We hypothesize that the injection of JP4-039, a mitochondria-targeted nitroxide, prior to irradiation of the mouse retina may decrease apoptosis and reduce neutrophil and macrophage migration into the retina. In our study, we aimed to exam…
View article: Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model Open
View article: Predatory Bacteria can Reduce<i>Pseudomonas aeruginosa</i>Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model
Predatory Bacteria can Reduce<i>Pseudomonas aeruginosa</i>Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model Open
Purpose Pseudomonas aeruginosa keratitis is a severe ocular infection that can lead to perforation of the cornea. In this study we evaluated the role of bacterial quorum sensing in generating corneal perforation and bacterial proliferation…
View article: Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD Open
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, we report that in retinal pigmented epithelial (RPE) cells, LCN2 r…
View article: Nonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa
Nonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa Open
Rhodopsin-associated (RHO-associated) retinitis pigmentosa (RP) is a progressive retinal disease that currently has no cure. RHO protein misfolding leads to disturbed proteostasis and the death of rod photoreceptors, resulting in decreased…
View article: Retinal ganglion cell survival after severe optic nerve injury is modulated by crosstalk between Jak/Stat signaling and innate immune responses in the zebrafish retina
Retinal ganglion cell survival after severe optic nerve injury is modulated by crosstalk between Jak/Stat signaling and innate immune responses in the zebrafish retina Open
Visual information is transmitted from the eye to the brain along the optic nerve, a structure composed of retinal ganglion cell (RGC) axons. The optic nerve is highly vulnerable to damage in neurodegenerative diseases, such as glaucoma, a…
View article: A whole-mount immunohistochemistry protocol for detection of mouse corneal nerves
A whole-mount immunohistochemistry protocol for detection of mouse corneal nerves Open
A cornea is innervated by sensory nerves, which branch into thick trunks, subbasal plexuses, and sensory endings. Appropriate assessment of nerve structure in a tissue provides a more complete understanding of the role of nerves in health …
View article: Stem cell-free therapy for glaucoma to preserve vision
Stem cell-free therapy for glaucoma to preserve vision Open
Glaucoma is the leading cause of irreversible blindness with trabecular meshwork (TM) dysfunction resulting in elevated intraocular pressure and retinal ganglion cell (RGC) damage leading to vision loss. In this study, we discovered that s…
View article: Retinal ganglion cell survival after severe optic nerve injury is modulated by crosstalk between JAK/STAT signaling and innate immune responses in the zebrafish retina
Retinal ganglion cell survival after severe optic nerve injury is modulated by crosstalk between JAK/STAT signaling and innate immune responses in the zebrafish retina Open
Visual information is transmitted from the eye to the brain along the optic nerve, a structure composed of retinal ganglion cell (RGC) axons. The optic nerve is highly vulnerable to damage in neurodegenerative diseases like glaucoma and th…
View article: Production of the Cytokine VEGF-A by CD4+ T and Myeloid Cells Disrupts the Corneal Nerve Landscape and Promotes Herpes Stromal Keratitis
Production of the Cytokine VEGF-A by CD4+ T and Myeloid Cells Disrupts the Corneal Nerve Landscape and Promotes Herpes Stromal Keratitis Open
View article: VEGF produced by CD4+ T cells and macrophages contributes to HSV-1 mediated ocular pathology by inducing sympathetic hyperinnervation of the cornea
VEGF produced by CD4+ T cells and macrophages contributes to HSV-1 mediated ocular pathology by inducing sympathetic hyperinnervation of the cornea Open
View article: Accurate tissue interface segmentation via adversarial pre-segmentation of anterior segment OCT images
Accurate tissue interface segmentation via adversarial pre-segmentation of anterior segment OCT images Open
Optical Coherence Tomography (OCT) is an imaging modality that has been widely adopted for visualizing corneal, retinal and limbal tissue structure with micron resolution. It can be used to diagnose pathological conditions of the eye, and …
View article: Inside and out: the roles of a stress response-cytolysin in corneal epithelial cell damage and intrastromal inflammation
Inside and out: the roles of a stress response-cytolysin in corneal epithelial cell damage and intrastromal inflammation Open
View article: Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells
Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells Open
Medical devices, such as contact lenses, bring bacteria in direct contact with human cells. Consequences of these host-pathogen interactions include the alteration of mammalian cell surface architecture and induction of cellular death that…
View article: Accurate Tissue Interface Segmentation via Adversarial Pre-Segmentation of Anterior Segment OCT Images
Accurate Tissue Interface Segmentation via Adversarial Pre-Segmentation of Anterior Segment OCT Images Open
Optical Coherence Tomography (OCT) is an imaging modality that has been widely adopted for visualizing corneal, retinal and limbal tissue structure with micron resolution. It can be used to diagnose pathological conditions of the eye, and …
View article: Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation
Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation Open
The retinal pigment epithelium (RPE) is a specialized monolayer of pigmented cells within the eye that is critical for maintaining visual system function. Diseases affecting the RPE have dire consequences for vision, and the most prevalent…
View article: Learning to Segment Corneal Tissue Interfaces in OCT Images
Learning to Segment Corneal Tissue Interfaces in OCT Images Open
Accurate and repeatable delineation of corneal tissue interfaces is necessary for surgical planning during anterior segment interventions, such as Keratoplasty. Designing an approach to identify interfaces, which generalizes to datasets ac…
View article: Structure–Function Changes of the Porcine Distal Outflow Tract in Response to Nitric Oxide
Structure–Function Changes of the Porcine Distal Outflow Tract in Response to Nitric Oxide Open
NO can dilate vessels of the distal outflow tract and increase outflow facility in a TM-independent fashion. There are short, focally constricting vessel sections that display large diameter changes and may have a substantial impact on out…
View article: Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep
Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep Open
Regions of radial, circumferential, and interweaving fibers occur in the posterior pole sclera of human, monkey, pig, sheep, cow, and goat eyes. The consistency across species in scleral architecture suggests that they are primary organiza…
View article: Abstract: Study of Retinochoroidal Circulation with Fluorescein Angiography after Whole Eye Transplantation in Rodents
Abstract: Study of Retinochoroidal Circulation with Fluorescein Angiography after Whole Eye Transplantation in Rodents Open
PURPOSE: Approximately 39 million people worldwide are blind. Whole eye transplantation (WET) could potentially provide a viable optical system to people worldwide with irreversible vision loss. As a first step toward realizing this goal, …
View article: Abstract: Whole Eye Transplantation: Allograft Survival with Tacrolimus Immunosupression and Comparison to Syngeneic Transplantation
Abstract: Whole Eye Transplantation: Allograft Survival with Tacrolimus Immunosupression and Comparison to Syngeneic Transplantation Open
PURPOSE: Visual impairment and blindness present significant economic, social and personal burdens for millions of patients and caregivers around the world. Whole eye transplantation (WET) is a potential solution. Our lab has established a…
View article: Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation
Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation Open
The retinal pigment epithelium (RPE) is a specialized monolayer of pigmented cells within the eye that is critical for maintaining visual system function. Diseases affecting the RPE have dire consequences for vision, and the most prevalent…
View article: Retinochoroidal Blood Flow is Demonstrated in an Orthotopic Vascularized Whole Eye Transplant Model
Retinochoroidal Blood Flow is Demonstrated in an Orthotopic Vascularized Whole Eye Transplant Model Open
Spatial Patterns and Age-Related Changes of the Collagen Crimp in the Human Cornea and Sclera Open
View article: Structure-Function Changes of the Distal Outflow Tract in Response to Nitric Oxide
Structure-Function Changes of the Distal Outflow Tract in Response to Nitric Oxide Open
Purpose: To correlate outflow function and outflow tract vessel diameter changes induced by nitric oxide (NO). Methods: In a porcine anterior segment perfusion model, the effects of a nitric oxide donor (100 µM DETA-NO) on outflow fa…
View article: Abstract 37: Whole Eye Allograft Transplantation And Immunosuppression: Survival Of The Transplanted Rodent Eye Using Tacrolimus Monotherapy
Abstract 37: Whole Eye Allograft Transplantation And Immunosuppression: Survival Of The Transplanted Rodent Eye Using Tacrolimus Monotherapy Open
PURPOSE: Visual impairment and blindness present significant social and economic burdens around the world. Whole eye transplantation (WET) is a potential solution. Our lab has established a viable rodent model and demonstrated promising re…
View article: Abstract QS29: Study of the Retinochoroidal Circulation with Fluorescein Angiography in a Rodent Orthotopic Whole Eye Transplantation Model
Abstract QS29: Study of the Retinochoroidal Circulation with Fluorescein Angiography in a Rodent Orthotopic Whole Eye Transplantation Model Open
PURPOSE: Whole eye transplantation (WET) could potentially provide a viable optical system to people worldwide with irreversible vision loss. As a first step toward realizing this goal, we have developed an orthotopic model for whole eye t…
View article: Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma
Age-related Changes in Eye, Brain and Visuomotor Behavior in the DBA/2J Mouse Model of Chronic Glaucoma Open
Although elevated intraocular pressure (IOP) and age are major risk factors for glaucoma, their effects on glaucoma pathogenesis remain unclear. This study examined the onset and progression of glaucomatous changes to ocular anatomy and ph…