Kiran Haresh Kumar Patel
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View article: WEIGHT LOSS REVERSES ADVERSE STRUCTURAL, ELECTROPHYSIOLOGICAL AND AUTONOMIC REMODELLING IN OBESITY
WEIGHT LOSS REVERSES ADVERSE STRUCTURAL, ELECTROPHYSIOLOGICAL AND AUTONOMIC REMODELLING IN OBESITY Open
Background Obesity is a global health problem that associates with cardiovascular disease and is an independent risk factor for cardiac arrhythmias. We previously showed QTc interval prolongs with increasing adiposity at a population level…
View article: The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability
The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability Open
The apicobasal repolarization gradient (ABRG) plays an important role in determining the sequence of ventricular repolarization, but the effects of sex and age on ABRG are unknown. In this study, we investigate the age‐ and sex‐related dif…
View article: A comparative study between open versus closed method of creation of pneumoperitoneum in laparoscopic surgeries
A comparative study between open versus closed method of creation of pneumoperitoneum in laparoscopic surgeries Open
Background: Gaining access to the peritoneal cavity is a critical step in laparoscopic surgeries and is associated with the risk of complications. The two most commonly used techniques for pneumoperitoneum creation are the open (Hasson can…
View article: Subepicardial adipose tissue as a modulator of arrhythmias
Subepicardial adipose tissue as a modulator of arrhythmias Open
View article: Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging
Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging Open
Aims Although electrical activity of the normal human heart is well characterized by the electrocardiogram, detailed insights into within-subject and between-subject variations of ventricular activation and recovery by noninvasive electroa…
View article: Bariatric surgery partially reverses subclinical proarrhythmic structural, electrophysiological, and autonomic changes in obesity
Bariatric surgery partially reverses subclinical proarrhythmic structural, electrophysiological, and autonomic changes in obesity Open
Obesity is associated with adverse electrophysiological, structural, and autonomic remodeling that is partially reversed after bariatric surgery. These data have important implications for bariatric surgery weight thresholds and weight los…
View article: Variant electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging
Variant electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging Open
Background and aims Although electrical activity of the normal human heart is well-characterized by the 12-lead electrocardiogram, detailed insights into within-subject and between-subject variations of ventricular activation and recovery …
View article: Information theory-based direct causality measure to assess cardiac fibrillation dynamics
Information theory-based direct causality measure to assess cardiac fibrillation dynamics Open
Understanding the mechanism sustaining cardiac fibrillation can facilitate the personalization of treatment. Granger causality analysis can be used to determine the existence of a hierarchical fibrillation mechanism that is more amenable t…
View article: Information theory-based direct causality measure to assess cardiac fibrillation dynamics
Information theory-based direct causality measure to assess cardiac fibrillation dynamics Open
This repository contains the optical imaging data used in the article "Information theory-based direct causality measure to assess cardiac fibrillation dynamics"
View article: Information theory-based direct causality measure to assess cardiac fibrillation dynamics
Information theory-based direct causality measure to assess cardiac fibrillation dynamics Open
This repository contains the optical imaging data used in the article "Information theory-based direct causality measure to assess cardiac fibrillation dynamics"
View article: Multiple anthropometric measures and proarrhythmic 12-lead ECG indices: A mendelian randomization study
Multiple anthropometric measures and proarrhythmic 12-lead ECG indices: A mendelian randomization study Open
Background Observational studies suggest that electrocardiogram (ECG) indices might be influenced by obesity and other anthropometric measures, though it is difficult to infer causal relationships based on observational data due to risk of…
View article: Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease
Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease Open
Importance Hypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity and are observationally associated with future maternal risk of cardiovascular disease. However, observational results may be subject to…
View article: A fully-automated paper ECG digitisation algorithm using deep learning
A fully-automated paper ECG digitisation algorithm using deep learning Open
View article: Obesity as a risk factor for cardiac arrhythmias
Obesity as a risk factor for cardiac arrhythmias Open
Obesity is global health problem with an estimated three billion people worldwide being classified as overweight or obese. In addition to being associated with a range of adverse health outcomes, obesity is linked to higher risks of atrial…
View article: Increasing Adiposity Is Associated With QTc Interval Prolongation and Increased Ventricular Arrhythmic Risk in the Context of Metabolic Dysfunction: Results From the UK Biobank
Increasing Adiposity Is Associated With QTc Interval Prolongation and Increased Ventricular Arrhythmic Risk in the Context of Metabolic Dysfunction: Results From the UK Biobank Open
Background Small-scale studies have linked obesity (Ob) and metabolic ill-health with proarrhythmic repolarisation abnormalities. Whether these are observed at a population scale, modulated by individuals’ genetics, and confer higher risks…
View article: Prognostic Significance of Ventricular Arrhythmias in 13 444 Patients With Acute Coronary Syndrome: A Retrospective Cohort Study Based on Routine Clinical Data (NIHR Health Informatics Collaborative VA‐ACS Study)
Prognostic Significance of Ventricular Arrhythmias in 13 444 Patients With Acute Coronary Syndrome: A Retrospective Cohort Study Based on Routine Clinical Data (NIHR Health Informatics Collaborative VA‐ACS Study) Open
Background A minority of acute coronary syndrome (ACS) cases are associated with ventricular arrhythmias (VA) and/or cardiac arrest (CA). We investigated the effect of VA/CA at the time of ACS on long‐term outcomes. Methods and Results We …
View article: Sleep Disordered Breathing, Obesity and Atrial Fibrillation: A Mendelian Randomisation Study
Sleep Disordered Breathing, Obesity and Atrial Fibrillation: A Mendelian Randomisation Study Open
It remains unclear whether the association between obstructive sleep apnoea (OSA), a form of sleep-disordered breathing (SDB), and atrial fibrillation (AF) is causal or mediated by shared co-morbidities such as obesity. Existing observatio…
View article: Epicardial adipose tissue as a mediator of cardiac arrhythmias
Epicardial adipose tissue as a mediator of cardiac arrhythmias Open
Obesity is associated with higher risks of cardiac arrhythmias. Although this may be partly explained by concurrent cardiometabolic ill-health, growing evidence suggests that increasing adiposity independently confers risk for arrhythmias.…
View article: Neural networks applied to 12-lead electrocardiograms predict body mass index, visceral adiposity and concurrent cardiometabolic ill-health
Neural networks applied to 12-lead electrocardiograms predict body mass index, visceral adiposity and concurrent cardiometabolic ill-health Open
View article: Increasing adiposity and the presence of cardiometabolic morbidity is associated with increased Covid-19-related mortality: results from the UK Biobank
Increasing adiposity and the presence of cardiometabolic morbidity is associated with increased Covid-19-related mortality: results from the UK Biobank Open
View article: Rotigaptide Infusion for the First 7 Days After Myocardial Infarction–Reperfusion Reduced Late Complexity of Myocardial Architecture of the Healing Border‐Zone and Arrhythmia Inducibility
Rotigaptide Infusion for the First 7 Days After Myocardial Infarction–Reperfusion Reduced Late Complexity of Myocardial Architecture of the Healing Border‐Zone and Arrhythmia Inducibility Open
Background Survivors of myocardial infarction are at increased risk of late ventricular arrhythmias, with infarct size and scar heterogeneity being key determinants of arrhythmic risk. Gap junctions facilitate the passage of small ions and…
View article: Proarrhythmic electrophysiological and structural remodeling in rheumatoid arthritis
Proarrhythmic electrophysiological and structural remodeling in rheumatoid arthritis Open
Chronic inflammatory disorders, including rheumatoid arthritis (RA), are associated with a twofold increase in the incidence of sudden cardiac death (SCD) compared with the healthy population. Although this is partly explained by an increa…
View article: Disease Severity and Exercise Testing Reduce Subcutaneous Implantable Cardioverter-Defibrillator Left Sternal ECG Screening Success in Hypertrophic Cardiomyopathy
Disease Severity and Exercise Testing Reduce Subcutaneous Implantable Cardioverter-Defibrillator Left Sternal ECG Screening Success in Hypertrophic Cardiomyopathy Open
Background— The features of the hypertrophic cardiomyopathy (HCM) ECG make it a challenge for subcutaneous implantable cardioverter-defibrillator (S-ICD) screening. We aimed to investigate the causes of screening failure at rest and on exe…
View article: An international survey of polypectomy training and assessment
An international survey of polypectomy training and assessment Open
Background and study aims Colonic polypectomy is acknowledged to be a technically challenging part of colonoscopy. Training in polypectomy is recognized to be often inconsistent. This study aimed to ascertain worldwide practice in polypect…
View article: Catheter ablation for atrial fibrillation in hypertrophic cardiomyopathy: a systematic review and meta-analysis
Catheter ablation for atrial fibrillation in hypertrophic cardiomyopathy: a systematic review and meta-analysis Open
Objective Atrial fibrillation (AF) is common in hypertrophic cardiomyopathy (HCM) and is associated with a high risk of stroke. The efficacy and safety of catheter ablation in this setting is poorly characterised. We aimed to systematicall…