Kirk Deitsch
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View article: <i>Plasmodium falciparum</i> DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification
<i>Plasmodium falciparum</i> DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification Open
The human malaria parasite, Plasmodium falciparum, faces unique DNA repair challenges; it is haploid, undergoes asynchronous mitosis termed schizogony, and lacks canonical non-homologous end joining (C-NHEJ). Yet, it has adapted DNA repair…
View article: <i>Plasmodium falciparum</i> DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification
<i>Plasmodium falciparum</i> DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification Open
The human malaria parasite, Plasmodium falciparum, faces unique DNA repair challenges; it is haploid, undergoes asynchronous mitosis termed schizogony, and lacks canonical non-homologous end joining (C-NHEJ). Yet, it has adapted DNA repair…
View article: The molecular basis of coordinated antigen switching enabling chronic infection by human malaria parasites
The molecular basis of coordinated antigen switching enabling chronic infection by human malaria parasites Open
The exceptional virulence of the human malaria parasite, Plasmodium falciparum , is in large part attributed to the adhesive properties of infected red blood cells and the parasite’s ability to avoid antibody recognition through antigenic …
View article: <i>Plasmodium falciparum</i> DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification
<i>Plasmodium falciparum</i> DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification Open
The haploid malaria parasite, Plasmodium falciparum, evolved a unique cohort of DNA repair pathways enabling the parasite to survive in a vertebrate host red blood cell and the mosquito vector. P. falciparum chromosomes are partitioned int…
View article: Two quantitative multiplex assays for the detection of P. falciparum asexual rings and male/female gametocyte developmental stages from human tissues
Two quantitative multiplex assays for the detection of P. falciparum asexual rings and male/female gametocyte developmental stages from human tissues Open
Background Malaria, caused by Plasmodium parasites, remains a significant global health challenge. Gametocytes are the sexual forms of the parasites which do not cause disease but are responsible for parasite transmission to the mosquito v…
View article: Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity
Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity Open
Chronic, asymptomatic malaria infections contribute substantially to disease transmission and likely represent the most significant impediment preventing malaria elimination and eradication. Plasmodium falciparum parasites evade antibody r…
View article: Chromatin structure and<i>var2csa</i>– a tango in regulation of<i>var</i>gene expression in the human malaria parasite,<i>Plasmodium falciparum</i>?
Chromatin structure and<i>var2csa</i>– a tango in regulation of<i>var</i>gene expression in the human malaria parasite,<i>Plasmodium falciparum</i>? Open
Over the last few decades, novel methods have been developed to study how chromosome positioning within the nucleus may play a role in gene regulation. Adaptation of these methods in the human malaria parasite, Plasmodium falciparum , has …
View article: Prevalence of Leucocytozoon infection in domestic birds in Ghana
Prevalence of Leucocytozoon infection in domestic birds in Ghana Open
Leucocytozoon is a haemosporidian parasite known to cause leucocytozoonosis in domestic and wild birds in most parts of the world. It is an important pathogen, as some species can be pathogenic, especially in domestic birds. One of the fac…
View article: The global transcriptome of <i>Plasmodium falciparum</i> mid-stage gametocytes (stages II–IV) appears largely conserved and gametocyte-specific gene expression patterns vary in clinical isolates
The global transcriptome of <i>Plasmodium falciparum</i> mid-stage gametocytes (stages II–IV) appears largely conserved and gametocyte-specific gene expression patterns vary in clinical isolates Open
Our overall understanding of the developmental biology of malaria parasites has been greatly enhanced by recent advances in transcriptomic analysis. However, most of these investigations rely on laboratory strains (LS) that were adapted in…
View article: The human malaria parasite<i>Plasmodium falciparum</i>can sense environmental changes and respond by antigenic switching
The human malaria parasite<i>Plasmodium falciparum</i>can sense environmental changes and respond by antigenic switching Open
The primary antigenic and virulence determinant of the human malaria parasite Plasmodium falciparum is a variant surface protein called PfEMP1. Different forms of PfEMP1 are encoded by a multicopy gene family called var , and switching bet…
View article: A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites
A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites Open
Malaria parasites avoid immune clearance through their ability to systematically alter antigens exposed on the surface of infected red blood cells. This is accomplished by tightly regulated transcriptional control of individual members of …
View article: Author response: A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites
Author response: A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Malaria p…
View article: A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites
A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites Open
Malaria parasites avoid immune clearance through their ability to systematically alter antigens exposed on the surface of infected red blood cells. This is accomplished by tightly regulated transcriptional control of individual members of …
View article: Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites
Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites Open
Cellular decision-making at the level of gene expression is a key process in the development and evolution of every organism. Variations in gene expression can lead to phenotypic diversity and the development of subpopulations with adaptiv…
View article: Metabolic competition between lipid metabolism and histone methylation regulates sexual differentiation in human malaria parasites.
Metabolic competition between lipid metabolism and histone methylation regulates sexual differentiation in human malaria parasites. Open
For Plasmodium falciparum, the most widespread and virulent human malaria parasite, persistence depends on continuous asexual replication in red blood cells, while transmission requires their differentiation into non-replicating gametocyte…
View article: The Role of the Histone Methyltransferase PfSET10 in Antigenic Variation by Malaria Parasites: a Cautionary Tale
The Role of the Histone Methyltransferase PfSET10 in Antigenic Variation by Malaria Parasites: a Cautionary Tale Open
The identification of specific epigenetic regulatory proteins in infectious organisms has become a high-profile research topic and a focus for several drug development initiatives. However, studies that define specific roles for different …
View article: Additional file 2 of Evolution of transcriptional control of antigenic variation and virulence in human and ape malaria parasites
Additional file 2 of Evolution of transcriptional control of antigenic variation and virulence in human and ape malaria parasites Open
Additional file 2: Description of individual sequences analyzed. This file provides a description of each sequence analyzed, organized according to species. Specific characteristics for each sequence are provided.
View article: Telomere length dynamics in response to DNA damage in malaria parasites
Telomere length dynamics in response to DNA damage in malaria parasites Open
SUMMARY Malaria remains a major cause of morbidity and mortality within the developing world. Recent work has implicated chromosome end stability and the repair of DNA breaks through telomere healing as potent drivers of variant antigen di…
View article: The contribution of extrachromosomal DNA to genome plasticity in malaria parasites
The contribution of extrachromosomal DNA to genome plasticity in malaria parasites Open
Malaria caused by the protozoan parasite Plasmodium falciparum continues to impose significant morbidity and mortality, despite substantial investment into drug and vaccine development and deployment. Underlying the resilience of this para…
View article: Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance
Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance Open
Malaria remains one of the most prevalent and deadly infectious diseases of the developing world, causing approximately 228 million clinical cases and nearly half a million deaths annually. The disease is caused by protozoan parasites of t…
View article: A Histone Methyltransferase Inhibitor Can Reverse Epigenetically Acquired Drug Resistance in the Malaria Parasite Plasmodium falciparum
A Histone Methyltransferase Inhibitor Can Reverse Epigenetically Acquired Drug Resistance in the Malaria Parasite Plasmodium falciparum Open
Malaria parasites invade and replicate within red blood cells (RBCs), extensively modifying their structure and gaining access to the extracellular environment by placing the plasmodial surface anion channel (PSAC) into the RBC membrane. E…
View article: A histone methyltransferase inhibitor can reverse epigenetically acquired drug resistance in the malaria parasite<i>Plasmodium falciparum</i>
A histone methyltransferase inhibitor can reverse epigenetically acquired drug resistance in the malaria parasite<i>Plasmodium falciparum</i> Open
Malaria parasites invade and replicate within red blood cells (RBCs), extensively modifying their structure and gaining access to the extracellular environment by placing the plasmodial surface anion channel (PSAC) into the RBC membrane. E…
View article: Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum
Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum Open
Malaria parasites possess the remarkable ability to maintain chronic infections that fail to elicit a protective immune response, characteristics that have stymied vaccine development and cause people living in endemic regions to remain at…
View article: Plasmodium falciparum malaria cases detected for prompt treatment by rapid diagnostic tests in the Ho Teaching Hospital of the Volta Region of Ghana
Plasmodium falciparum malaria cases detected for prompt treatment by rapid diagnostic tests in the Ho Teaching Hospital of the Volta Region of Ghana Open
This study shows that RDT is a useful tool in promoting prompt diagnosis and management of malaria and though children form a majority of hospital attendees and malaria infections, the frequency of malaria detection may be higher in adults…