Explanipedia

A systematic approach to study the effects of acquisition parameters and biological factors on computerized mammography analysis using ex vivo human tissue: A protocol description Open

Angie Hernández, Tomppa Pakarinen, Annukka Salminen, Samuel Castro, Ulla Karhunen‐Enckell , et al. · 2025

Background: Mammography is the most common imaging modality for the detection of breast cancer. Artificial intelligence algorithms for mammography analysis have shown promising performance for breast cancer risk assessment and lesion detec…

CEMIPek hantura iraunarazten du larruazaleko melanoman azido hialuronikoaren metabolismoaren bidez Open

M. Ruiz, Ainhoa Alonso‐Pardavila, Sanna Oikari, Sanna Pasonen‐Seppänen, Kirsi Rilla , et al. · 2025

Pisu molekular altuko azido hialuronikoak (PMA-AH) anti-hantura ezaugarriak dituen osagaia da zelulaz kanpoko matrizean (ZKM); pisu molekular baxukoak (PMB-AH), ostera, hantura bultzatzen du. CEMIP (ingelesezko cell migration inducing prot…

Indole-3-propionic acid promotes hepatic stellate cells inactivation Open

Mariana Ilha, Ratika Sehgal, Johanna Matilainen, Kirsi Rilla, Dorota Kamińska , et al. · 2025

Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers Open

Gautier Follain, Sujan Ghimire, Joanna W. Pylvänäinen, Monika Vaitkevičiūtė, Diana H Wurzinger , et al. · 2024

Leukocyte extravasation is a key component of the innate immune response, while circulating tumor cell extravasation is a critical step in metastasis formation. Despite their importance, the mechanisms underlying leukocyte and tumor cell e…

PL3 CendR peptide shows specific uptake in cultured Y79 retinoblastoma cells with nucleolar accumulation Open

Sonja Korhonen, Stef Bosch, Antero Erkinheimo, Tatu Lajunen, Kirsi Rilla , et al. · 2024

Retinoblastoma is the most common pediatric intraocular malignant tumor affecting 1:15 000-1:20 000 live births. Even though the survival rate in developed countries is over 90 %, more efficient treatment options are needed for better visi…

Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity Open

Johanna Matilainen, Viivi Berg, Maija Vaittinen, Ulla Impola, Anne‐Mari Mustonen , et al. · 2024

Development of Focused Ultrasound-Assisted Nanoplexes for RNA Delivery Open

Sanjeev Ranjan, Stef Bosch, Hannamari Lukkari, Johanna Schirmer, Niina Aaltonen , et al. · 2024

RNA-based therapeutics, including siRNA, have obtained recognition in recent years due to their potential to treat various chronic and rare diseases. However, there are still limitations to lipid-based drug delivery systems in the clinical…

EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells Open

Jasmin Huttunen, Niina Aaltonen, Laura Helminen, Kirsi Rilla, Ville Paakinaho · 2024

The androgen receptor (AR) is a primary target for treating prostate cancer (PCa), forming the bedrock of its clinical management. Despite their efficacy, resistance often hampers AR-targeted therapies, necessitating new strategies against…

High Numbers of CD163+ Tumor-Associated Macrophages Predict Poor Prognosis in HER2+ Breast Cancer Open

Minna Jääskeläinen, Ritva Tumelius, Kirsi Hämäläinen, Kirsi Rilla, Sanna Oikari , et al. · 2024

Tumor-associated macrophages (TAMs) are associated with a poor outcome in breast cancer (BC), but their prognostic value in different BC subtypes has remained somewhat unclear. Here, we investigated the prognostic value of M2-like TAMs (CD…

DPYSL5 is highly expressed in treatment-induced neuroendocrine prostate cancer and promotes lineage plasticity via EZH2/PRC2 Open

Roosa Kaarijärvi, Heidi Kaljunen, Lucia Nappi, Ladan Fazli, Sonia H.Y. Kung , et al. · 2024

Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a lethal subtype of castration-resistant prostate cancer resistant to androgen receptor (AR) inhibitors. Our study unveils that AR suppresses the neuronal development protein dih…

Selective drug delivery to the retinal cells: Biological barriers and avenues Open

Eva Ramsay, Tatu Lajunen, Madhushree Bhattacharya, Mika Reinisalo, Kirsi Rilla , et al. · 2023

Retinal drug delivery is a challenging, but important task, because most retinal diseases are still without any proper therapy. Drug delivery to the retina is hampered by the anatomical and physiological barriers resulting in minimal bioav…

The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer Open

Minna Jääskeläinen, Satu Tiainen, Hanna Siiskonen, Maarit Ahtiainen, Teijo Kuopio , et al. · 2023

Counts of hyaluronic acid-containing extracellular vesicles decrease in naturally occurring equine osteoarthritis Open

Anne‐Mari Mustonen, Nina Lehmonen, Sanna Oikari, Janne Capra, Marja Raekallio , et al. · 2022

A quick pipeline for the isolation of 3D cell culture‐derived extracellular vesicles Open

Heikki Kyykallio, Alessandra Valéria de Sousa Faria, Rosabella Hartman, Janne Capra, Kirsi Rilla , et al. · 2022

Recent advances in cell biology research regarding extracellular vesicles have highlighted an increasing demand to obtain 3D cell culture‐derived EVs, because they are considered to more accurately represent EVs obtained in vivo . However,…

Isolation of Extracellular Vesicles From the Bronchoalveolar Lavage Fluid of Healthy and Asthmatic Horses Open

Nina Höglund, Ninna Koho, Heini Rossi, Jenni Karttunen, Anne‐Mari Mustonen , et al. · 2022

Extracellular vesicles (EVs) are membrane-bound particles that engage in inflammatory reactions by mediating cell–cell interactions. Previously, EVs have been isolated from the bronchoalveolar lavage fluid (BALF) of humans and rodents. The…

Fatty Acid Fingerprints and Hyaluronic Acid in Extracellular Vesicles from Proliferating Human Fibroblast-like Synoviocytes Open

Anne‐Mari Mustonen, Tommi Paakkonen, Johanna Matilainen, Kirsi Rilla, Reijo Käkelä , et al. · 2022

Extracellular vesicles (EVs) function as conveyors of fatty acids (FAs) and other bioactive lipids and can modulate the gene expression and behavior of target cells. EV lipid composition influences the fluidity and stability of EV membrane…

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease Open

Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R. Liddell, Dzhessi Rait , et al. · 2022

Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether and how transmit…

Microscopic characterization reveals the diversity of EVs secreted by GFP-HAS3 expressing MCF7 cells Open

Janne Capra, Kai Härkönen, Heikki Kyykallio, Helena Vihinen, Eija Jokitalo , et al. · 2022

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration Open

Niina Aaltonen, Heikki Kyykallio, Sylvain Tollis, Janne Capra, Jaana M. Hartikainen , et al. · 2022

Invasion of tumor cells through the stroma is coordinated in response to migratory cues provided by the extracellular environment. One of the most abundant molecules in the tumor microenvironment is hyaluronan, a glycosaminoglycan known to…

Alzheimer’s disease alters astrocytic functions related to neuronal support and transcellular internalization of mitochondria Open

Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R. Liddell, Dzhessi Rait , et al. · 2021

Under physiological conditions in vivo astrocytes internalize and degrade neuronal mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in neurodegeneration but it is unknown whether and how transmit…

Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding Open

Kirsi Rilla · 2021

Plasma membrane curvature is an important factor in the regulation of cellular phenotype and is critical for various cellular activities including the shedding of extracellular vesicles (EV). One of the most striking morphological features…

The power of imaging to understand extracellular vesicle biology in vivo Open

Frederik J. Verweij, Leonora Balaj, Chantal M. Boulanger, David R. F. Carter, Ewoud B. Compeer , et al. · 2021

Enhanced gene expression by a novel designed leucine zipper endosomolytic peptide Open

Aqeel Ahmad, Kirsi Rilla, Jing Zou, Weikai Zhang, Ilmari Pyykkö , et al. · 2021

An endosomal trap is a major barrier in gene therapy. We have designed an endosomolytic peptide based on the leucine zipper sequence and characterized it both structurally and functionally. The results illustrated that leucine zipper endos…

Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid arthritis Open

Anne‐Mari Mustonen, Janne Capra, Kirsi Rilla, Petri Lehenkari, Sanna Oikari , et al. · 2021

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ Open

Mikael Marttinen, Catarina B. Ferreira, Kaisa M. A. Paldanius, Mari Takalo, Teemu Natunen , et al. · 2020

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by aberrant amyloid-β (Aβ) and hyperphosphorylated tau aggregation. We have previously investigated the involvement of SEPTIN family members in AD-related cellular proce…

The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype Open

Satu Tiainen, Kirsi Rilla, Kirsi Hämäläinen, Sanna Oikari, Päivi Auvinen · 2020

Purpose The aim of this study was to investigate the prognostic impact of two systemic inflammatory markers, the neutrophil-to-lymphocyte ratio (NLR) and the monocyte-to-lymphocyte ratio (MLR), and their possible predictive role regarding …

The Density and Length of Filopodia Associate with the Activity of Hyaluronan Synthesis in Tumor Cells Open

Heikki Kyykallio, Sanna Oikari, María Bueno Álvez, Carlos J. Gallardo-Dodd, Janne Capra , et al. · 2020

Filopodia are multifunctional finger-like plasma membrane protrusions with bundles of actin filaments that exist in virtually all cell types. It has been known for some time that hyaluronan synthesis activity induces filopodial growth. How…

Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism Open

Johanna Matilainen, Anne‐Mari Mustonen, Kirsi Rilla, Reijo Käkelä, Sanna P. Sihvo , et al. · 2020

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils Open

Niina Aaltonen, Prosanta Singha, Hermina Jakupović, Thomas Wirth, Haritha Samaranayake , et al. · 2020

Additional file 3 of High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils Open

Niina Aaltonen, Prosanta Singha, Hermina Jakupović, Thomas Wirth, Haritha Samaranayake , et al. · 2020

Additional file 3. Complete LC-MS/MS data of all proteins identified from the ABPP gel-pieces.

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