Kirsten Smalley
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View article: ΔNp63 maintains the fidelity of the myoepithelial cell lineage and directs cell differentiation programs in the murine salivary gland
ΔNp63 maintains the fidelity of the myoepithelial cell lineage and directs cell differentiation programs in the murine salivary gland Open
Salivary glands consist of several epithelial cell types of distinct lineages and functional characteristics that are established by directed differentiation programs of resident stem and progenitor cells. We have shown that ΔNp63, a cruci…
View article: Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland
Genetic Study of Elf5 and Ehf in the Mouse Salivary Gland Open
Salivary gland (SG) development, maturation, and homeostasis require coordinated roles of transcription factors (TFs) that dictate specific cell identities and fate. The ETS family of proteins are important transcriptional drivers of diver…
View article: Transcriptomic and Single-Cell Analysis of the Murine Parotid Gland
Transcriptomic and Single-Cell Analysis of the Murine Parotid Gland Open
The salivary complex of mammals consists of 3 major pairs of glands: the parotid, submandibular, and sublingual glands. While the 3 glands share similar functional properties, such as saliva secretion, their differences are largely based o…
View article: Functional characterization and genomic studies of a novel murine submandibular gland epithelial cell line
Functional characterization and genomic studies of a novel murine submandibular gland epithelial cell line Open
A better understanding of the normal and diseased biology of salivary glands (SG) has been hampered, in part, due to difficulties in cultivating and maintaining salivary epithelial cells. Towards this end, we have generated a mouse salivar…
View article: RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation
RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation Open
Our RNA-seq based Atlas has revealed a high-resolution cartographic view of the dynamic transcriptomic landscape of the mouse SG at various stages. These RNA-seq datasets will complement pre-existing microarray based datasets, including th…
View article: Additional file 7: Table S1. of RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation
Additional file 7: Table S1. of RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation Open
Developmental gene signature. Table S2. Common genes expressed between salivary gland, pancreas, skin, bladder and placenta. Table S3. Common genes expressed between salivary gland and pancreas. Table S4. Adult gene signature. Table S5. HP…