Kirsty McDowell
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View article: Artificial intelligence fully automated analysis of handheld echocardiography in real‐world patients with suspected heart failure
Artificial intelligence fully automated analysis of handheld echocardiography in real‐world patients with suspected heart failure Open
Aims Echocardiography is a rate‐limiting step in the timely diagnosis of heart failure (HF). Automated reporting of echocardiograms has the potential to streamline workflow. The aim of this study was to test the diagnostic accuracy of full…
View article: Cellular Adhesion Molecules and Adverse Outcomes in Chronic Heart Failure
Cellular Adhesion Molecules and Adverse Outcomes in Chronic Heart Failure Open
Importance Vascular cell adhesion molecule 1 (VCAM-1) and intracellular cell adhesion molecule 1 (ICAM-1) are responsible for immune cell-cell interactions. Systemic levels of VCAM-1 are associated with incident heart failure (HF). Objecti…
View article: Interleukin-6 in Heart Failure With Reduced Ejection Fraction and the Effect of Dapagliflozin
Interleukin-6 in Heart Failure With Reduced Ejection Fraction and the Effect of Dapagliflozin Open
In DAPA-HF, elevated IL-6 and hs-CRP levels were each associated with the risk of worsening HF or cardiovascular death. Dapagliflozin reduced the risk of adverse outcomes regardless of baseline IL-6 or hs-CRP. (Study to Evaluate the Effect…
View article: Prognostic Models for Mortality and Morbidity in Heart Failure With Preserved Ejection Fraction
Prognostic Models for Mortality and Morbidity in Heart Failure With Preserved Ejection Fraction Open
Importance Accurate risk prediction of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) may help clinicians risk stratify and inform care decisions. Objective To develop and validate a novel p…
View article: Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes
Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes Open
Aims Neuropeptide Y (NPY) is the most abundant neuropeptide found in the heart and is released alongside norepinephrine following prolonged sympathetic activation, a process that is implicated in the pathophysiology of heart failure (HF). …
View article: Defining Myocardial Injury in COVID-19: Is Troponin Enough? The COVID-19 Disease and Cardiac Events (Covicare) Study
Defining Myocardial Injury in COVID-19: Is Troponin Enough? The COVID-19 Disease and Cardiac Events (Covicare) Study Open
Background: Myocardial injury is a complication of COVID-19 infection and is associated with adverse outcome, but the definition is variable and based on troponin elevation alone. We utilised a revised definition of myocardial injury using…
View article: Heart failure with preserved ejection fraction, red cell distribution width, and sacubitril/valsartan
Heart failure with preserved ejection fraction, red cell distribution width, and sacubitril/valsartan Open
Aims Red cell distribution width (RDW) is a strong prognostic marker in patients with heart failure (HF) and reduced ejection fraction and other conditions. However, very little is known about its prognostic significance in HF with preserv…
View article: Association of Carbohydrate Antigen 125 on the Response to Dapagliflozin in Patients With Heart Failure
Association of Carbohydrate Antigen 125 on the Response to Dapagliflozin in Patients With Heart Failure Open
In DAPA-HF, elevated CA125 levels were an independent predictor of the risk of worsening HF or cardiovascular death. Dapagliflozin reduced the risk of worsening HF or cardiovascular death regardless of baseline CA125.
View article: Cardiotoxicity of BRAF/MEK Inhibitors
Cardiotoxicity of BRAF/MEK Inhibitors Open
View article: Incremental prognostic value of biomarkers in <scp>PARADIGM‐HF</scp>
Incremental prognostic value of biomarkers in <span>PARADIGM‐HF</span> Open
Aims It is uncertain how much candidate biomarkers improve risk prediction when added to comprehensive models including routinely collected clinical and laboratory variables in heart failure. Methods and results Aldosterone, cystatin C, hi…
View article: A comprehensive study of the incremental prognostic value of novel biomarkers in PARADIGM-HF (Bio-PREDICT-HF)
A comprehensive study of the incremental prognostic value of novel biomarkers in PARADIGM-HF (Bio-PREDICT-HF) Open
Background Although multiple novel biomarkers have individually been shown to predict outcomes in patients with HFrEF, the value of these over and above conventional clinical and laboratory variables, plus natriuretic peptides, is uncertai…
View article: Dapagliflozin reduces uric acid concentration, an independent predictor of adverse outcomes in <scp>DAPA‐HF</scp>
Dapagliflozin reduces uric acid concentration, an independent predictor of adverse outcomes in <span>DAPA‐HF</span> Open
Aims Blood uric acid (UA) levels are frequently elevated in patients with heart failure and reduced ejection fraction (HFrEF), may lead to gout and are associated with worse outcomes. Reduction in UA is desirable in HFrEF and sodium–glucos…
View article: Sodium-glucose cotransporter 2 inhibitors: the first universal treatment for heart failure?
Sodium-glucose cotransporter 2 inhibitors: the first universal treatment for heart failure? Open
View article: ACE-2 Downregulation and Incidence of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Infection
ACE-2 Downregulation and Incidence of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Infection Open
View article: Characterizing Cardiac Involvement in Chronic Kidney Disease Using CMR—a Systematic Review
Characterizing Cardiac Involvement in Chronic Kidney Disease Using CMR—a Systematic Review Open
CMR has diagnostic utility to identify and characterize cardiac involvement in this patient group. A number of papers have described novel findings over the last 3 years, suggesting that CMR has potential to become more widely used in stud…