Mark Fung
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Exploring the Impact of Pickleball for Improving Mood in First-Year University Students—A Pilot Study in Japan Open
Background: Pickleball has gained global popularity as a socially engaging and accessible sport, but little is known about its short-term psychological effects on younger populations, particularly university students. This pilot study exam…
View article: Platelet Transfusion
Platelet Transfusion Open
Importance Platelet transfusion is a frequent procedure with benefits and risks. Objective To provide recommendations in adult and pediatric populations in whom platelet transfusions are commonly performed. Evidence Review Grading of Recom…
View article: Why do people still make anti‐D over 50 years after the introduction of Rho(D) immune globulin? A Biomedical Excellence for Safer Transfusion (BEST) Collaborative study
Why do people still make anti‐D over 50 years after the introduction of Rho(D) immune globulin? A Biomedical Excellence for Safer Transfusion (BEST) Collaborative study Open
Background Rho(D) immune globulin (RhIg) is used to reduce RhD alloimmunization in pregnancy. This study describes potential causes for RhD alloimmunization after the development and implementation of RhIg. Study Design and Methods This re…
Understanding Health-Related Discussions on Reddit: Development of a Topic Assignment Method and Exploratory Analysis Open
Background Social media has become a widely used way for people to share opinions about health care and medical topics. Social media data can be leveraged to understand patient concerns and provide insight into why patients may turn to the…
A retrospective multi-site examination of chronic kidney disease using longitudinal laboratory results and metadata to identify clinical and financial risk Open
Background A retrospective observational study was conducted at 3 health care organizations to identify clinical gaps in care for patients with stage 3 or 4 chronic kidney disease (CKD), and financial opportunity from U.S. risk adjustment …
Laboratory Literacy: Surveying Lab Result Interpretations of a Local Patient Population Open
A patient's independent interpretation of their medical laboratory data has become an unspoken prerequisite in the current age of medicine. In the outpatient setting, it is anecdotally commonplace for patients to receive their lab results …
View article: Small‐volume blood sample collection tubes in adult <scp>intensive care units</scp>: A rapid practice guideline
Small‐volume blood sample collection tubes in adult <span>intensive care units</span>: A rapid practice guideline Open
Background This Intensive Care Medicine Rapid Practice Guideline (ICM‐RPG) provides an evidence‐based recommendation to address the question: in adult patients in intensive care units (ICUs), should we use small‐volume or conventional bloo…
Multi-level factors linked to young adult primary care transitions: evidence from a state all-payer claims analysis Open
Objective Delayed transitions from pediatric to adult primary care leads to gaps in medical care. State all-payer claims data was used to assess multilevel factors associated with timely transition from pediatric to adult primary care. Mat…
View article: Systematic review for the serological testing for cold agglutinins: The <scp>BEST</scp> collaborative study
Systematic review for the serological testing for cold agglutinins: The <span>BEST</span> collaborative study Open
The investigation of suspected cold agglutinins (CA) can be challenging and highly resource-intensive. While progress has been made in the clinical understanding and management of patients with CA with new therapeutic options,1-5 there has…
A Retrospective Multi-site Examination of Chronic Kidney Disease Using Longitudinal Laboratory Results and Metadata to Identify Clinical and Financial Risk Open
(350 words) Background: A retrospective, non-experimental, non-interventional study was conducted at 3 health care organizations to identify clinical gaps in care for patients with stage 3 or 4 chronic kidney disease (CKD), and financial o…
View article: A global analysis of the use of immunoglobulin, shortages in supply, and mitigating measures: A survey of hospital providers (a <scp>BEST</scp> Collaborative study)
A global analysis of the use of immunoglobulin, shortages in supply, and mitigating measures: A survey of hospital providers (a <span>BEST</span> Collaborative study) Open
Background Immunoglobulin (IG) therapy is widely used to treat primary and secondary immune deficiencies and as immunomodulatory agent for various disorders. There is great concern that shortages of IG may rise, potentially affecting medic…
View article: Classification of posttransfusion adverse events using a publicly available artificial intelligence system
Classification of posttransfusion adverse events using a publicly available artificial intelligence system Open
Background Correct classification of transfusion reactions is important not only for effective patient care and donor management but also for accurate tracking of events in hemovigilance systems. We compared the ability of a generative art…
Understanding Health-Related Discussions on Reddit: Development of a Topic Assignment Method and Exploratory Analysis (Preprint) Open
BACKGROUND Social media has become a widely used way for people to share opinions about health care and medical topics. Social media data can be leveraged to understand patient concerns and provide insight into why patients may turn to the…
Understanding barriers and facilitators of appropriate antibiotic use: a qualitative analysis of an online parenting forum Open
Purpose Antibiotic use and misuse are common in pregnant women and young children. Few studies have assessed real-world discussions of antibiotics in these populations. Using social media posts of pregnant women and parents, our goal was t…
Defining and identifying laboratory literacy as a component of health literacy: An assessment of existing health literacy tools Open
Health literacy has been defined and studied as an important component of a patient's ability to understand and obtain appropriate healthcare. However, a laboratory component of health literacy, as it pertains to the understanding of labor…
View article: A Primer on Gene Editing: What Does It Mean for Pathologists?
A Primer on Gene Editing: What Does It Mean for Pathologists? Open
Context Gene editing–based therapies are currently in development in the areas of oncology, inherited disease, and infectious disease. These potentially life-altering therapies are derived from decades of research in both academic and indu…
View article: A Review of Laboratory Practices Using the HLA-B27 Survey by the College of American Pathologists: How Important Is Allele-Level Typing?
A Review of Laboratory Practices Using the HLA-B27 Survey by the College of American Pathologists: How Important Is Allele-Level Typing? Open
Context.— Ankylosing spondylitis (AS) is an autoimmune disorder with a strong genetic risk, especially with HLA-B27. Clinical testing for HLA-B27 has been used to help diagnose patients with signs and symptoms of AS. Testing methods used b…
View article: The safety of <scp>COVID</scp>‐19 convalescent plasma donation: A <scp>multi‐institutional</scp> donor hemovigilance study
The safety of <span>COVID</span>‐19 convalescent plasma donation: A <span>multi‐institutional</span> donor hemovigilance study Open
Background Although the safety and therapeutic efficacy of COVID‐19 convalescent plasma (CCP) has been extensively evaluated, the safety of CCP donation has not been explored in a multi‐institutional context. Study design and methods Nine …
A Primer on Chimeric Antigen Receptor T-cell Therapy: What Does It Mean for Pathologists? Open
Context.— Chimeric antigen receptor T-cell (CAR-T) technology has shown great promise in both clinical and preclinical models in mediating potent and specific antitumor activity. With the advent of US Food and Drug Administration–approved …
View article: Monthly hemostatic factor variability in women and men
Monthly hemostatic factor variability in women and men Open
Hormonal status influences hemostatic factors including fibrinogen, factor VII and plasminogen activator inhibitor (PAI-1), and concentrations differ among men, premenopausal and postmenopausal women. This study examines how phases of the …
A national survey of hospital‐based transfusion services on their approaches to platelet bacterial risk mitigation in response to the <span>FDA</span> final guidance for industry Open
BACKGROUND Bacterial contamination of platelets is the leading infectious risk to the United States (US) blood supply. On 30 September 2019, the US Food and Drug Administration (FDA) published a Final Guidance for Industry to reduce the ri…
Platelets treated with pathogen reduction technology: current status and future direction Open
Allogeneic platelets collected for transfusion treated with pathogen reduction technology (PRT), which has been available in some countries for more than a decade, are now increasingly available in the United States (US). The implementatio…
Social Determinants of Health Among Blood Donors Open
Understanding the influences of social determinants of health (SDOH) on blood donation may help define the relationship between health in a community and rates of blood donation. While much is known about the demographics of blood donors i…