Kay L. Double
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View article: Copper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model
Copper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model Open
Misfolded wild-type superoxide dismutase 1 (disSOD1) protein is implicated in the death of substantia nigra (SN) dopamine neurons in Parkinson disease. Regionally reduced copper availability, and subsequent reduced copper binding to SOD1, …
View article: Imaging Copper Levels during Life in the Brain and beyond Using a Fluorescent Copper Sensor with Multimodal Capacity
Imaging Copper Levels during Life in the Brain and beyond Using a Fluorescent Copper Sensor with Multimodal Capacity Open
Copper is an essential trace element for normal development and function throughout the body, including the central nervous system (CNS). Alterations to cellular copper levels result in severe neurological consequences and are linked to a …
View article: Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model
Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model Open
Atypical wild-type superoxide dismutase 1 (SOD1) protein misfolding and deposition occurs specifically within the degenerating substantia nigra pars compacta (SNc) in Parkinson disease. Mechanisms driving the formation of this pathology an…
View article: Copper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model
Copper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model Open
Wild-type superoxide dismutase 1 (disSOD1) protein misfolding and deposition is implicated in the death of substantia nigra (SN) dopamine neurons in Parkinson disease. Regionally reduced copper availability, and subsequent reduced copper b…
View article: Impaired maturation of wild-type superoxide dismutase 1 associated with neurodegeneration in Parkinson disease brain and a novel murine model
Impaired maturation of wild-type superoxide dismutase 1 associated with neurodegeneration in Parkinson disease brain and a novel murine model Open
Atypical wild-type superoxide dismutase 1 (SOD1) protein misfolding and deposition occurs specifically within the degenerating substantia nigra pars compacta (SNc) in Parkinson disease. Mechanisms driving the formation of this pathology an…
View article: The background and experience of neuroscience teachers in Australian universities: A cross-sectional survey
The background and experience of neuroscience teachers in Australian universities: A cross-sectional survey Open
Neuroscience is an academic discipline taught within a broad range of university degrees and programs. The expertise and experience of neuroscience teaching staff contribute to the student’s learning experience and knowledge acquisition. W…
View article: Empirically derived formulae for calculation of age- and region-related levels of iron, copper and zinc in the adult C57BL/6 mouse brain
Empirically derived formulae for calculation of age- and region-related levels of iron, copper and zinc in the adult C57BL/6 mouse brain Open
Metal dyshomeostasis is associated with neurodegenerative disorders, cancers and vascular disease. We report the effects of age (range: 3 to 18 months) on regional copper, iron and zinc levels in the brain of the C57BL/6 mouse, a widely us…
View article: A Near-Infrared Ratiometric Fluorescent Probe for Detecting Endogenous Cu2+ in the Brain
A Near-Infrared Ratiometric Fluorescent Probe for Detecting Endogenous Cu2+ in the Brain Open
Copper participates in a range of critical functions in the nervous system in the human brain. Disturbances in brain copper content is strongly associated with neurological disease. For example, changes in the level and distribution of cop…
View article: A Century of Progress on Wilson Disease and the Enduring Challenges of Genetics, Diagnosis, and Treatment
A Century of Progress on Wilson Disease and the Enduring Challenges of Genetics, Diagnosis, and Treatment Open
Wilson disease (WD) is a rare, inherited metabolic disorder manifested with varying clinical presentations including hepatic, neurological, psychiatric, and ophthalmological features, often in combination. Causative mutations in the ATP7B …
View article: Coupling SEC and IEF to SXRF for metallation analysis of SOD1 enzyme isolated from the human central nervous system
Coupling SEC and IEF to SXRF for metallation analysis of SOD1 enzyme isolated from the human central nervous system Open
International audience
View article: Motor cortical excitability and pre‐supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity
Motor cortical excitability and pre‐supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity Open
Substantia nigra (SN) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for Parkinson's disease. We hypothesized that SN hyperechogenicity in healthy adults aged 50–70 years is associated with reduced short‐interval …
View article: Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration
Co-deposition of SOD1, TDP-43 and p62 proteinopathies in ALS: evidence for multifaceted pathways underlying neurodegeneration Open
Multiple neurotoxic proteinopathies co-exist within vulnerable neuronal populations in all major neurodegenerative diseases. Interactions between these pathologies may modulate disease progression, suggesting they may constitute targets fo…
View article: Empirical evidence for biometal dysregulation in Parkinson’s disease from a systematic review and Bradford Hill analysis
Empirical evidence for biometal dysregulation in Parkinson’s disease from a systematic review and Bradford Hill analysis Open
The Bradford Hill model evaluates the causal inference of one variable on another by assessing whether evidence of the suspected causal variable aligns with a set of nine criteria proposed by Bradford Hill, each representing fundamental te…
View article: Microglial ferroptotic stress causes non-cell autonomous neuronal death
Microglial ferroptotic stress causes non-cell autonomous neuronal death Open
Background Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing …
View article: Unraveling the Physiological Correlates of Mental Workload Variations in Tracking and Collision Prediction Tasks
Unraveling the Physiological Correlates of Mental Workload Variations in Tracking and Collision Prediction Tasks Open
Modern work environments have extensive interactions with technology and greater cognitive complexity of the tasks, which results in human operators experiencing increased mental workload. Air traffic control operators routinely work in su…
View article: Native Separation and Metallation Analysis of SOD1 Protein from the Human Central Nervous System: a Methodological Workflow
Native Separation and Metallation Analysis of SOD1 Protein from the Human Central Nervous System: a Methodological Workflow Open
Studies of the metal content of metalloproteins in tissues from the human central nervous system (CNS) can be compromised by preparative techniques which alter levels of, or interactions between, metals and the protein of interest within a…
View article: Measurement of the adult human midbrain with transcranial ultrasound
Measurement of the adult human midbrain with transcranial ultrasound Open
Background Transcranial sonography is increasingly used to aid clinical diagnoses of movement disorders, for example, to identify an enlarged area of substantia nigra echogenicity in patients with Parkinson’s disease. Objective The current…
View article: Unravelling the Physiological Correlates of Mental Workload Variations in Tracking and Collision Prediction Tasks: Implications for Air Traffic Controllers
Unravelling the Physiological Correlates of Mental Workload Variations in Tracking and Collision Prediction Tasks: Implications for Air Traffic Controllers Open
Objective We have designed tracking and collision prediction tasks to elucidate the differences in the physiological response to the workload variations in basic ATC tasks to untangle the impact of workload variations experienced by operat…
View article: Native Separation and Metallation Analysis of SOD1 Protein from the Human Central Nervous System: A Methodological Workflow
Native Separation and Metallation Analysis of SOD1 Protein from the Human Central Nervous System: A Methodological Workflow Open
We developed a methodological workflow combining size exclusion chromatography, native isoelectric focusing, and high sensitivity X-ray-based metal detection within electrophoresis gels to analyze the metal content of single proteins purif…
View article: Native Separation and Metallation Analysis of SOD1 Protein from the Human Central Nervous System: A Methodological Workflow
Native Separation and Metallation Analysis of SOD1 Protein from the Human Central Nervous System: A Methodological Workflow Open
We developed a methodological workflow combining size exclusion chromatography, native isoelectric focusing, and high sensitivity X-ray-based metal detection within electrophoresis gels to analyze the metal content of single proteins purif…
View article: Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic
Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic Open
Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide breakdown and is important for most forms of eukaryotic life. The evolution of aerobic respiration by mitochondria increased cellular production of s…
View article: Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic
Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic Open
Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide breakdown and is important for most forms of eukaryotic life. The evolution of aerobic respiration by mitochondria increased cellular production of s…
View article: Simultaneous structural and elemental nano-imaging of human brain tissue
Simultaneous structural and elemental nano-imaging of human brain tissue Open
Structural and chemical characterisation of microfeatures in unadulterated Parkinson's disease brain tissue using synchrotron nanoscale XFM and ptychography.
View article: Meta‐Analysis of Copper and Iron in Parkinson's Disease Brain and Biofluids
Meta‐Analysis of Copper and Iron in Parkinson's Disease Brain and Biofluids Open
Background Variations in study quality and design complicate interpretation of the clinical significance of consistently reported changes in copper and iron levels in human Parkinson's disease brain and biofluids. Methods We systematically…
View article: Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease Open
Parkinson's disease prevalence is rapidly increasing in an aging global population. With this increase comes exponentially rising social and economic costs, emphasizing the immediate need for effective disease‐modifying treatments. Motor d…
View article: Levels of glial cell line‐derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease
Levels of glial cell line‐derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease Open
Growth factors can facilitate hippocampus‐based learning and memory and are potential targets for treatment of cognitive dysfunction via their neuroprotective and neurorestorative effects. Dementia is common in Parkinson’s disease (PD), bu…