Carson K. L. Lo
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View article: 636. <i>Pneumocystis</i> Pneumonia Outcomes in Solid Organ Transplant Recipients and Patients Living with HIV: A Population-Based Study Over 20 Years (2002-2022) in Ontario, Canada
636. <i>Pneumocystis</i> Pneumonia Outcomes in Solid Organ Transplant Recipients and Patients Living with HIV: A Population-Based Study Over 20 Years (2002-2022) in Ontario, Canada Open
Background While it is well established that HIV-positive and non-HIV immunocompromised patients are susceptible to Pneumocystis pneumonia (PCP), comparing PCP outcomes between patients with different underlying immunocompromising conditio…
View article: Holy water not so holy: Potential source of Elizabethkingia pneumonia and bacteremia in an immunocompromised host
Holy water not so holy: Potential source of Elizabethkingia pneumonia and bacteremia in an immunocompromised host Open
Elizabethkingia species are Gram-negative, glucose-non-fermenting bacilli predominantly found in soil and water, with Elizabethkingia anophelis increasingly recognized as a human pathogen. E. anophelis has also been re…
View article: Less Is More? Two Cases of Cryptococcosis Treated Using Single-dose Liposomal Amphotericin B as Part of Induction Therapy in Solid Organ Transplant Recipients
Less Is More? Two Cases of Cryptococcosis Treated Using Single-dose Liposomal Amphotericin B as Part of Induction Therapy in Solid Organ Transplant Recipients Open
In solid organ transplant (SOT), cryptococcosis causes invasive fungal infection by reactivated latent infection (median onset 15–19 wk posttransplantation), donor-derived transmission, or posttransplant de novo infection.1,2 Clinical pres…
View article: Evaluating in vivo effectiveness of sotrovimab for the treatment of Omicron subvariant BA.2 versus BA.1: a multicentre, retrospective cohort study
Evaluating in vivo effectiveness of sotrovimab for the treatment of Omicron subvariant BA.2 versus BA.1: a multicentre, retrospective cohort study Open
Background In vitro data suggested reduced neutralizing capacity of sotrovimab, a monoclonal antibody, against Omicron BA.2 subvariant. However, limited in vivo data exist regarding clinical effectiveness of sotrovimab for coronavirus dise…
View article: Methodological and Reporting Quality of Noninferiority Randomized Controlled Trials Comparing Antiretroviral Therapies: A Systematic Review
Methodological and Reporting Quality of Noninferiority Randomized Controlled Trials Comparing Antiretroviral Therapies: A Systematic Review Open
Background It is unclear whether the reporting quality of antiretroviral (ARV) noninferiority (NI) randomized controlled trials (RCTs) has improved since the CONSORT guideline release in 2006. The primary objective of this systematic revie…
View article: Comparison of Preprint Postings of Randomized Clinical Trials on COVID-19 and Corresponding Published Journal Articles
Comparison of Preprint Postings of Randomized Clinical Trials on COVID-19 and Corresponding Published Journal Articles Open
Importance Randomized clinical trials (RCTs) on COVID-19 are increasingly being posted as preprints before publication in a scientific, peer-reviewed journal. Objective To assess time to journal publication for COVID-19 RCT preprints and t…
View article: Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis
Prognostic factors for streptococcal toxic shock syndrome: systematic review and meta-analysis Open
Objectives To quantify the prognostic effects of demographic and modifiable factors in streptococcal toxic shock syndrome (STSS). Design Systematic review and meta-analysis. Data sources MEDLINE, EMBASE and CINAHL from inception to 19 Sept…
View article: Staphylococcus aureus bacteremia mortality across country income groups: A secondary analysis of a systematic review
Staphylococcus aureus bacteremia mortality across country income groups: A secondary analysis of a systematic review Open
In SAB studies, LMIC are poorly represented. In-hospital mortality was significantly higher in MIC than in HIC. Research should be conducted in LMIC to characterize differences in care processes driving the mortality gap.
View article: <i>Aspergillus fumigatus</i>sternal osteomyelitis following cardiac surgery: Case report and literature review
<i>Aspergillus fumigatus</i>sternal osteomyelitis following cardiac surgery: Case report and literature review Open
BACKGROUND: Sternal osteomyelitis caused by Aspergillus spp is uncommon in cardiac surgery patients requiring sternotomy. CASE PRESENTATION: We report a 77-year-old male with a history of poorly controlled diabetes who was diagnosed with A…
View article: What Is the Optimal Follow-up Length for Mortality in <i>Staphylococcus aureus</i> Bacteremia? Observations From a Systematic Review of Attributable Mortality
What Is the Optimal Follow-up Length for Mortality in <i>Staphylococcus aureus</i> Bacteremia? Observations From a Systematic Review of Attributable Mortality Open
Background Deaths following Staphylococcus aureus bacteremia (SAB) may be related or unrelated to the infection. In SAB therapeutics research, the length of follow-up should be optimized to capture most attributable deaths and minimize non…
View article: How Generalizable Are Randomized Controlled Trials (RCTs) in <i>Staphylococcus aureus</i> Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies
How Generalizable Are Randomized Controlled Trials (RCTs) in <i>Staphylococcus aureus</i> Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies Open
In Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths in RCTs contribute to this mortality…
View article: Méningite à <i>Mycobacterium tuberculosis</i> chez une immigrante récemment arrivée au Canada
Méningite à <i>Mycobacterium tuberculosis</i> chez une immigrante récemment arrivée au Canada Open
[Voir la version anglaise de l’article ici : www.cmaj.ca/lookup/doi/10.1503/cmaj.210740][1] Points clés Une femme de 37 ans a consulté dans un hôpital communautaire pour céphalée frontale intense, fièvre subjective et épisodes confusionnel…
View article: Secondary Analysis of a Systematic Review: Are Antifungal Noninferiority Trials at Risk of Eroding Effectiveness Because of Biocreep?
Secondary Analysis of a Systematic Review: Are Antifungal Noninferiority Trials at Risk of Eroding Effectiveness Because of Biocreep? Open
Noninferiority randomized controlled trial (RCT) effectiveness may erode when results favor the active control over time and when a decreasingly effective control arm is used in serial trials. We analyzed 32 antifungal noninferiority RCTs …
View article: Meningitis caused by <i>Mycobacterium tuberculosis</i> in a recent immigrant to Canada
Meningitis caused by <i>Mycobacterium tuberculosis</i> in a recent immigrant to Canada Open
KEY POINTS A 37-year-old woman presented to a community hospital with a 1-week history of severe frontal headache, subjective fever and episodic confusion. She denied having nausea, vomiting, seizures or rash. She had immigrated to Canada …
View article: Confidence interval of risk difference by different statistical methods and its impact on the study conclusion in antibiotic non-inferiority trials
Confidence interval of risk difference by different statistical methods and its impact on the study conclusion in antibiotic non-inferiority trials Open
View article: Management of <i>Mycobacterium tuberculosis</i> Prosthetic Joint Infection: 2 Cases and Literature Review
Management of <i>Mycobacterium tuberculosis</i> Prosthetic Joint Infection: 2 Cases and Literature Review Open
Prosthetic joint infection caused by Mycobacterium tuberculosis (TBPJI) is uncommon but can be encountered in immunocompromised patients or those from tuberculosis-endemic regions. A lack of clinical suspicion and experience with TBPJI oft…
View article: Carnobacterium inhibens isolated in blood culture of an immunocompromised, metastatic cancer patient: a case report and literature review
Carnobacterium inhibens isolated in blood culture of an immunocompromised, metastatic cancer patient: a case report and literature review Open
View article: Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review
Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review Open
View article: Additional file 3 of Confidence interval of risk difference by different statistical methods and its impact on the study conclusion in antibiotic non-inferiority trials
Additional file 3 of Confidence interval of risk difference by different statistical methods and its impact on the study conclusion in antibiotic non-inferiority trials Open
Additional file 3:. Supplementary Material 3
View article: Additional file 2 of Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review
Additional file 2 of Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review Open
Additional file 2.
View article: Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review
Novel Antibiotics May Be Noninferior but Are They Becoming Less Effective?: a Systematic Review Open
Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a dec…