Klarissa Hanja Stürner

A new screening tool for early recognition of ATTRv polyneuropathy in clinical practice: AmyloScan® Open

Juliane Sachau, Lena Rhode, Maike F. Dohrn, Jan Vollert, Stefanie Rehm , et al. · 2025

Hereditary transthyretin (ATTRv) amyloidosis is a progressive multisystem disorder, mainly characterized by cardiac dysfunction and polyneuropathy. Due to its rarity and heterogeneous presentation, diagnosis is often delayed, which has a d…

AI-based assessment of longitudinal multiple sclerosis MRI: Strengths and weaknesses in clinical practice Open

Sönke Peters, Lars Schmill, Carl Alexander Gless, Klarissa Hanja Stürner, Olav Jansen , et al. · 2025

For the evaluation of follow up MR images of MS patients, an AI-based imaging analysis can be beneficial in clinical routine, especially due to a very high negative predictive value.

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases Open

Carina Saggau, Petra Bächer, Daniela Esser, Mahdi Rasa, Silja Meise , et al. · 2024

Pro-inflammatory autoantigen-specific CD4⁺ T helper (auto-Th) cells are central orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in human AIDs with defined autoantigens by combining human leukocy…

AI supported detection of cerebral multiple sclerosis lesions decreases radiologic reporting times Open

Sönke Peters, Gesa Kellermann, J.S. Watkinson, Friederike Gärtner, Monika Huhndorf , et al. · 2024

For the evaluation of MR images of MS patients, an AI-based support for image-interpretation can significantly decreases reporting times.

Automatic lesion detection at Multiple Sclerosis patients – Comparison of 2D- and 3D-FLAIR-datasets Open

Svea Seehafer, Lars-Patrick Schmill, Schekeb Aludin, Monika Huhndorf, Naomi Larsen , et al. · 2024

Automatic lesion counting and volumetry is feasible with both 2D- and 3D-weightend FLAIR images. Still, it leads to partly significant differences even between two sequences that both are conform to the 2021 MAGNIMS-CMSCNAIMS consensus rec…

Investigating the metabolite signature of an altered oral microbiota as a discriminant factor for multiple sclerosis: a pilot study Open

Léo Boussamet, Emmanuel Montassier, Camille Mathé, Alexandra Garcia, J. Morille , et al. · 2024

In multiple sclerosis (MS), alterations of the gut microbiota lead to inflammation. However, the role of other microbiomes in the body in MS has not been fully elucidated. In a pilot case-controlled study, we carried out simultaneous chara…

Objectively assessed sleep quality parameters in Multiple Sclerosis at home: Association to disease, disease severity and physical activity Open

V. Vinod, Karolina Saegner, Walter Maetzler, Elke Warmerdam, Robbin Romijnders , et al. · 2024

This is one of the few studies with a wrist-worn accelerometer that shows a difference in sleep efficiency between MS patients and controls and, in MS, an association of sleep quality variables with PA variables.

Detection of Spinal Cord Multiple Sclerosis Lesions Using a 3D-PSIR Sequence at 1.5 T Open

Sönke Peters, Fernando Bueno Neves, Monika Huhndorf, Friederike Gärtner, Klarissa Hanja Stürner , et al. · 2024

Purpose Multiple sclerosis (MS) is a prevalent autoimmune inflammatory disease. Besides cerebral manifestations, an affection of the spinal cord is typical; however, imaging of the spinal cord is difficult due to its anatomy. The aim of th…

Chronic Enterovirus Meningoencephalitis in Prolonged B-Cell Depletion After Rituximab Therapy Open

Clemens Jacksch, Justina Dargvainiene, Sindy Böttcher, Sabine Diedrich, Frank Leypoldt , et al. · 2023

This case report should emphasize the importance of assessing humoral immunity even years after B-cell depletion therapy, especially in case of opportunistic infections.

Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases – a retrospective cross-sectional study Open

Felix Brauchle, Daniel Rapp, Makbule Şenel, André Huss, Jens Dreyhaupt , et al. · 2023

Introduction The polyspecific intrathecal immune response (PSIIR), aka MRZ reaction ( M = measles, R = rubella, Z = zoster, optionally Herpes simplex virus, HSV) is defined as intrathecal immunoglobulin synthesis (IIS) for two or more unre…

Turning When Using Smartphone in Persons With and Those Without Neurologic Conditions: Observational Study Open

Edoardo Bianchini, Elke Warmerdam, Robbin Romijnders, Klarissa Hanja Stürner, Ralf Baron , et al. · 2023

Background Turning during walking is a relevant and common everyday movement and it depends on a correct top-down intersegmental coordination. This could be reduced in several conditions (en bloc turning), and an altered turning kinematics…

Autologous haematopoietic stem cell transplantation for multiple sclerosis: a position paper and registry outline Open

Antonios Bayas, Achim Berthele, Norbert Blank, Peter Dreger, Simon Faissner , et al. · 2023

Background: While substantial progress has been made in the development of disease-modifying medications for multiple sclerosis (MS), a high percentage of treated patients still show progression and persistent inflammatory activity. Autolo…

Comprehensive Implementation of Shared Decision Making in a Neuromedical Center Using the SHARE TO CARE Program Open

Constanze Stolz-Klingenberg, Claudia Bünzen, Marie Coors, Charlotte Flüh, Klarissa Hanja Stürner , et al. · 2023

The S2C program has been successfully implemented within the entire Neuromedical Center. Patients reported a medium to small increase of perceived involvement in decision making demonstrating the effectiveness of the implementation. For fu…

Turning when using a smartphone in persons with and without neurologic conditions: an observational study (Preprint) Open

Edoardo Bianchini, Elke Warmerdam, Robbin Romijnders, Klarissa Hanja Stürner, Ralf Baron , et al. · 2022

BACKGROUND Turning during walking is a relevant and common everyday movement and it depends on a correct top-down intersegmental coordination. This could be reduced in several conditions (en-bloc turning), and an altered turning kinematic…

Postural Sway in Parkinson's Disease and Multiple Sclerosis Patients During Tasks With Different Complexity Open

Elke Warmerdam, Maike Schumacher, Thorben Beyer, Patrik Theodor Nerdal, Linda Schebesta , et al. · 2022

Neurological diseases are associated with static postural instability. Differences in postural sway between neurological diseases could include “conceptual” information about how certain symptoms affect static postural stability. This info…

B-cell-depletion reverses dysbiosis of the microbiome in multiple sclerosis patients Open

Alba Troci, Olga Zimmermann, Daniela Esser, Paula Krampitz, Sandra May , et al. · 2022

To elucidate cross-sectional patterns and longitudinal changes of oral and stool microbiota in multiple sclerosis (MS) patients and the effect of B-cell depletion. We conducted an observational, longitudinal clinical cohort study analysing…

Treating sarcoidosis-associated progressive multifocal leukoencephalopathy with infliximab Open

Sina C. Rosenkranz, Vivien Häußler, Manuela Kolster, Anne Willing, Jakob Matschke , et al. · 2021

Although most of the progressive multifocal leukoencephalopathy cases in sarcoidosis patients are explained by the treatment with immunosuppressive drugs, it is also reported in treatment-naive sarcoidosis patients, which implies a general…

B-Cell-Depletion Reverses Dysbiosis of the Microbiome in Multiple Sclerosis Patients Open

Alba Troci, Olga Zimmermann, Daniela Esser, Paula Krampitz, Sandra May , et al. · 2021

Objective: To elucidate cross-sectional patterns and longitudinal changes of oral and stool microbiota in multiple sclerosis (MS) patients and the effect of B-cell depletion.Methods: We conducted an observational, longitudinal clinical coh…

Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging Open

Christian Thaler, Anna A. Kyselyova, Tobias D. Faizy, Marie Teresa Nawka, Sune Nørhøj Jespersen , et al. · 2021

Background Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders. Methods Thirty-seven patients with relap…

Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis Open

Klarissa Hanja Stürner, Oliver Werz, Andreas Koeberle, Markus Otto, Ole Pleß , et al. · 2020

Lipid mediators (LMs) are a unique class of immunoregulatory signalling molecules and known to be affected by frankincense extracts. We performed LM profiling by metabololipidomics in plasma samples from 28 relapsing-remitting multiple scl…

Is multiple sclerosis progression associated with the HLA-DR15 haplotype? Open

Klarissa Hanja Stürner, Inessa Siembab, Gerhard Schön, Jan‐Patrick Stellmann, Nika Heidari , et al. · 2019

Background The prevalence of multiple sclerosis is associated with the major histocompatibility complex class II DR15 haplotype HLA-DRB1*15:01∼HLA-DRB5*01:01. Objective To assess whether multiple sclerosis progression is associated with th…

Development of Cortical Lesion Volumes on Double Inversion Recovery MRI in Patients With Relapse-Onset Multiple Sclerosis Open

Tobias D. Faizy, Gabriel Broocks, Christian Thaler, Geraldine Rauch, Pimrapat Gebert , et al. · 2019

Background and Objective: In multiple sclerosis (MS) patients, Double Inversion Recovery (DIR) magnetic resonance imaging (MRI) can be used to detect cortical lesions (CL). While the quantity and distribution of CLs seems to be asso…

A case of CLIPPERS syndrome responsive to tocilizumab Open

Torge Rempe, Jos Becktepe, Imke Metz, Wolfgang Brück, Klarissa Hanja Stürner , et al. · 2019

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder consisting of (1) subacute clinical brainstem signs and symptoms, (2) characteristic punctate and curvilin…

Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring Open

Daniel Stoessel, Jan‐Patrick Stellmann, Anne Willing, Birte Behrens, Sina C. Rosenkranz , et al. · 2018

Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currentl…

A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial) Open

Klarissa Hanja Stürner, Jan‐Patrick Stellmann, Jan Dörr, Friedemann Paul, Tim Friede , et al. · 2017

Objective To investigate whether oral administration of a standardised frankincense extract (SFE) is safe and reduces disease activity in patients with relapsing-remitting multiple sclerosis (RRMS). Methods We performed an investigator-ini…

Reliability of cortical lesion detection on double inversion recovery MRI applying the MAGNIMS-Criteria in multiple sclerosis patients within a 16-months period Open

Tobias D. Faizy, Christian Thaler, Tim Ceyrowski, Gabriel Broocks, Natascha Treffler , et al. · 2017

After a first assessment, slightly less than a half of the CL were considered as reliably detectable on longitudinal DIR images. A retrospective re-evaluation notably increased the consensus agreement. However, this finding is narrowed, co…

Maraviroc as possible treatment for PML-IRIS in natalizumab-treated patients with MS Open

Sibylle Hodecker, Klarissa Hanja Stürner, V. Becker, Birte Elias-Hamp, Brigitte Holst , et al. · 2017

Progressive multifocal leukoencephalopathy (PML) is a serious complication of natalizumab treatment in patients with relapsing-remitting MS (RRMS)1 with 638 confirmed cases as of March 2016. Therapeutic re-establishment of cerebral immune …

T1 Recovery Is Predominantly Found in Black Holes and Is Associated with Clinical Improvement in Patients with Multiple Sclerosis Open

Christian Thaler, Tobias D. Faizy, Jan Sedlacik, Brigitte Holst, Klarissa Hanja Stürner , et al. · 2016

BACKGROUND AND PURPOSE: Quantitative MR imaging parameters help to evaluate disease progression in multiple sclerosis and increase correlation with clinical disability. We therefore hypothesized that T1 values might be a marker for ongoing…

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation Open

Till F. M. Andlauer, Dorothea Buck, Gisela Antony, Antonios Bayas, Lukas Bechmann , et al. · 2016

Genome-wide study in Germans identifies four novel multiple sclerosis risk genes and confirms already known gene loci.

Correction: Increased Perfusion in Normal Appearing White Matter in High Inflammatory Multiple Sclerosis Patients Open

Maxim Bester, Nils D. Forkert, Jan Patrick Stellmann, Klarissa Hanja Stürner, Lilian Aly , et al. · 2015

Purpose Although cerebral perfusion alterations have long been acknowledged in multiple sclerosis (MS), the relationship between measurable perfusion changes and the status of highly active MS has not been examined. We hypothesized that …

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