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View article: Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression
Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression Open
Cellular systems responsible for the formation and removal of reactive oxygen species (ROS), functioning within physiological limits, are essential for maintaining intracellular redox balance. This state is known as oxidative eustress. Key…
View article: Flavonoids and their role in oxidative stress, inflammation, and human diseases
Flavonoids and their role in oxidative stress, inflammation, and human diseases Open
Oxidative stress and chronic inflammation are important drivers in the pathogenesis and progression of many chronic diseases, such as cancers of the breast, kidney, lung, and others, autoimmune diseases (rheumatoid arthritis), cardiovascul…
View article: Erratum to “Frentizole derivatives with mTOR inhibiting and senomorphic properties” [Biomed. Pharmacother. 167 (2023) 115600]
Erratum to “Frentizole derivatives with mTOR inhibiting and senomorphic properties” [Biomed. Pharmacother. 167 (2023) 115600] Open
View article: The role of redox-active iron, copper, manganese, and redox-inactive zinc in toxicity, oxidative stress, and human diseases
The role of redox-active iron, copper, manganese, and redox-inactive zinc in toxicity, oxidative stress, and human diseases Open
Given the key importance played by the redox-active metals iron (Fe), copper (Cu), and manganese (Mn) in vital cellular processes, such as DNA synthesis, oxidative phosphorylation, the detoxification of reactive oxygen species (ROS), and a…
View article: Heavy metals: toxicity and human health effects
Heavy metals: toxicity and human health effects Open
View article: Assessing the potential role of arbuscular mycorrhizal fungi in improving the phytochemical content and antioxidant properties in Gomphrena globosa
Assessing the potential role of arbuscular mycorrhizal fungi in improving the phytochemical content and antioxidant properties in Gomphrena globosa Open
Strategies to increase the secondary metabolite production, obtained from medicinal plants has been the topic of research in recent years. The symbiotic interaction between arbuscular mycorrhizal fungi and plants allows host-fungus pairing…
View article: c-Jun N-terminal kinase signaling in aging
c-Jun N-terminal kinase signaling in aging Open
Aging encompasses a wide array of detrimental effects that compromise physiological functions, elevate the risk of chronic diseases, and impair cognitive abilities. However, the precise underlying mechanisms, particularly the involvement o…
View article: Leprosy: Comprehensive insights into pathology, immunology, and cutting-edge treatment strategies, integrating nanoparticles and ethnomedicinal plants
Leprosy: Comprehensive insights into pathology, immunology, and cutting-edge treatment strategies, integrating nanoparticles and ethnomedicinal plants Open
Mycobacterium leprae is the causative agent responsible for the chronic disease known as leprosy. This condition is characterized by dermal involvement, often leading to peripheral nerve damage, sensory-motor loss, and related abnormalitie…
View article: The role of cellular senescence in neurodegenerative diseases
The role of cellular senescence in neurodegenerative diseases Open
View article: Antioxidant versus prooxidant properties of the flavonoid, galangin: ROS scavenging activity, flavonoid-DNA interaction, copper-catalyzed Fenton reaction and DNA damage study
Antioxidant versus prooxidant properties of the flavonoid, galangin: ROS scavenging activity, flavonoid-DNA interaction, copper-catalyzed Fenton reaction and DNA damage study Open
Flavonoids are natural antioxidants, found in vegetables, fruits, flowers, coffee, tea, wine, and other foodstuffs. They are well known for their health benefits, and various clinical trials have determined that a sufficient intake of flav…
View article: Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants Open
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious or beneficial to biological systems. An imbalance between ROS production and elimination is…
View article: Frentizole derivatives with mTOR inhibiting and senomorphic properties
Frentizole derivatives with mTOR inhibiting and senomorphic properties Open
View article: Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging Open
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is characterized by low to mild levels of oxidants involved in the re…
View article: Laboratórne cvičenia z biochémie
Laboratórne cvičenia z biochémie Open
Predkladaný študijný materiál je určený študentom rozširujúceho štúdia učiteľstva chémie, ktorí v rámci predmetu Biochémia absolvujú základné laboratórne cvičenia z biochémie blokovou formou. Experimentálna práca v laboratóriu má za cieľ o…
View article: Plasma PD-L1 as a biomarker in the clinical management of glioblastoma multiforme—a retrospective cohort study
Plasma PD-L1 as a biomarker in the clinical management of glioblastoma multiforme—a retrospective cohort study Open
Background and objectives Glioblastoma multiforme (GBM) is the most aggressive, malignant, and therapy-resistant tumor of the brain. Blockade therapy targeting the programmed cell death protein 1 (PD-1)/programmed death ligand (PD-L1) axis…
View article: Essential metals in health and disease
Essential metals in health and disease Open
In total, twenty elements appear to be essential for the correct functioning of the human body, half of which are metals and half are non-metals. Among those metals that are currently considered to be essential for normal biological functi…
View article: Sheep Wool Humidity under Electron Irradiation Affects Wool Sorptivity towards Co(II) Ions
Sheep Wool Humidity under Electron Irradiation Affects Wool Sorptivity towards Co(II) Ions Open
The effect of humidity on sheep wool during irradiation by an accelerated electron beam was examined. Each of the samples with 10%, 53%, and 97% relative humidity (RH) absorbed a dose of 0, 109, and 257 kGy, respectively. After being freel…
View article: Testing of electron beam irradiated sheep wool for adsorption of Cr(III) and Co(II) of higher concentrations
Testing of electron beam irradiated sheep wool for adsorption of Cr(III) and Co(II) of higher concentrations Open
View article: Antioxidant vs. Prooxidant Properties of the Flavonoid, Kaempferol, in the Presence of Cu(II) Ions: A ROS-Scavenging Activity, Fenton Reaction and DNA Damage Study
Antioxidant vs. Prooxidant Properties of the Flavonoid, Kaempferol, in the Presence of Cu(II) Ions: A ROS-Scavenging Activity, Fenton Reaction and DNA Damage Study Open
Kaempferol is a flavonoid that occurs in tea and in many vegetables and fruits, including broccoli, cabbage, beans, grapes, apples, and strawberries. The efficacy of Kaempferol has been demonstrated in the treatment of breast, esophageal, …
View article: EPR study of effect of ascorbic acid on hair and feather samples in relation to eumelanins and pheomelanins
EPR study of effect of ascorbic acid on hair and feather samples in relation to eumelanins and pheomelanins Open
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View article: Antimicrobial and antifungal activities of bifunctional cooper(ii) complexes with non-steroidal anti-inflammatory drugs, flufenamic, mefenamic and tolfenamic acids and 1,10-phenanthroline
Antimicrobial and antifungal activities of bifunctional cooper(ii) complexes with non-steroidal anti-inflammatory drugs, flufenamic, mefenamic and tolfenamic acids and 1,10-phenanthroline Open
Cooper( ii ) complexes represent a promising group of compounds with antimicrobial and antifungal properties. In the present work, a series of Cu( ii ) complexes containing the non-steroidal anti-inflammatory drugs, tolfenamic acid, mefena…
View article: Radiation-modified wool for adsorption of redox metals and potentially for nanoparticles
Radiation-modified wool for adsorption of redox metals and potentially for nanoparticles Open
Electron beam irradiated sheep wool with absorbed radiation doses ranging from 0 to 165 kGy showed good adsorption properties toward copper cations. The Cu( ii ) being Lewis acid generated several types of complex salts based on carboxylat…
View article: Some Properties of Electron Beam-Irradiated Sheep Wool Linked to Cr(III) Sorption
Some Properties of Electron Beam-Irradiated Sheep Wool Linked to Cr(III) Sorption Open
We examined the characteristics of an electron beam irradiated wool with an absorbed dose of (21–410) kGy in comparison with natural wool with respect to the determination of the isoelectric point (IEP), zero charge point (ZCP), mechanism …
View article: A Switch between Antioxidant and Prooxidant Properties of the Phenolic Compounds Myricetin, Morin, 3′,4′-Dihydroxyflavone, Taxifolin and 4-Hydroxy-Coumarin in the Presence of Copper(II) Ions: A Spectroscopic, Absorption Titration and DNA Damage Study
A Switch between Antioxidant and Prooxidant Properties of the Phenolic Compounds Myricetin, Morin, 3′,4′-Dihydroxyflavone, Taxifolin and 4-Hydroxy-Coumarin in the Presence of Copper(II) Ions: A Spectroscopic, Absorption Titration and DNA Damage Study Open
The beneficial effects of polyphenols, predominantly in the context of oxidative stress-related diseases such as cancer, cardiovascular diseases and neurological conditions including Alzheimer’s and Parkinson’s diseases, have been document…
View article: CCDC 1410708: Experimental Crystal Structure Determination
CCDC 1410708: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1410711: Experimental Crystal Structure Determination
CCDC 1410711: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1410712: Experimental Crystal Structure Determination
CCDC 1410712: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1410704: Experimental Crystal Structure Determination
CCDC 1410704: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1410709: Experimental Crystal Structure Determination
CCDC 1410709: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1410710: Experimental Crystal Structure Determination
CCDC 1410710: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …