Klaudia Laborc
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View article: Myelin pathology is a key feature of X-linked Dystonia Parkinsonism
Myelin pathology is a key feature of X-linked Dystonia Parkinsonism Open
X-linked Dystonia-Parkinsonism (XDP) is a progressive, adult-onset neurodegenerative movement disorder that predominantly affects males of Filipino descent. The disease is caused by the insertion of a SINE-VNTR-Alu subfamily F (SVA_F) retr…
View article: Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies
Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies Open
Tauopathies are neurodegenerative diseases characterized by pathological tau accumulation, leading to motor and neuropsychiatric symptoms. Effective tau-targeting therapies remain a major challenge. Here, we present 1D9-LIRΔTP53INP2, a sin…
View article: CamKIIα and VPAC1 Expressions in the Caudal Trigeminal Nucleus of Rats After Systemic Nitroglycerin Treatment: Interaction with Anandamide
CamKIIα and VPAC1 Expressions in the Caudal Trigeminal Nucleus of Rats After Systemic Nitroglycerin Treatment: Interaction with Anandamide Open
Migraines are a frequently occurring neurological condition that affects up to 16% of the global population. The precise pathomechanism of the disease remains unknown, but from animal and human observations, it appears that calcium/calmodu…
View article: THU117 Lipocalin-2 As A Mediator Of Negative Affect After Sepsis
THU117 Lipocalin-2 As A Mediator Of Negative Affect After Sepsis Open
Disclosure: S.E. Yang: None. C. Johnston: None. K. Laborc: None. S. Kounelis-Wuillaume: None. W. Schwieterman: None. A.R. Hill: None. J.L. Spencer-Segal: None. Sepsis is characterized by a life-threatening response to severe infection incl…
View article: Activation of the trigeminal system in the animal models of migraine
Activation of the trigeminal system in the animal models of migraine Open
Migraine is one of the most common primary headaches, affecting up to 10% of the Hungarian population.The exact pathogenesis is still not fully understood, but the activation of the trigeminovascular system and neurogenic inflammation have…
View article: Corticosteroid Treatment During Sepsis Alters Hippocampal Function in Male and Female Survivors
Corticosteroid Treatment During Sepsis Alters Hippocampal Function in Male and Female Survivors Open
Corticosterone treatment during sepsis impaired memory formation in survivors and caused a lasting decrease in hippocampal neural activity, which could underlie its effect on memory. Future studies should focus on how this lasting effect o…
View article: Forebrain Glucocorticoid Receptor Overexpression Alters Behavioral Encoding of Hippocampal CA1 Pyramidal Cells in Mice
Forebrain Glucocorticoid Receptor Overexpression Alters Behavioral Encoding of Hippocampal CA1 Pyramidal Cells in Mice Open
Glucocorticoid signaling influences hippocampal-dependent behavior and vulnerability to stress-related neuropsychiatric disorders. In mice, lifelong overexpression of glucocorticoid receptor (GR) in forebrain excitatory neurons altered exp…
View article: Forebrain glucocorticoid receptor overexpression alters behavioral encoding of hippocampal CA1 pyramidal cells in mice
Forebrain glucocorticoid receptor overexpression alters behavioral encoding of hippocampal CA1 pyramidal cells in mice Open
Stress hormone signaling via the glucocorticoid receptor (GR) modulates vulnerability to stress-related disorders, but whether GR influences how the brain encodes contextual experience is unknown. Mice with lifelong GR overexpression in fo…
View article: Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid
Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid Open
View article: Corrigendum: The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
Corrigendum: The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat Open
[This corrects the article DOI: 10.3389/fneur.2017.00278.].
View article: Trigeminal activation patterns evoked by chemical stimulation of the dura mater in rats
Trigeminal activation patterns evoked by chemical stimulation of the dura mater in rats Open
View article: Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction
Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction Open
View article: Persistent Neuroinflammation and Brain-Specific Immune Priming in a Novel Survival Model of Murine Pneumosepsis
Persistent Neuroinflammation and Brain-Specific Immune Priming in a Novel Survival Model of Murine Pneumosepsis Open
Pneumonia is the leading cause of sepsis and septic shock. Patients who survive pneumonia are vulnerable to long-term complications including increased risk of neurocognitive dysfunction. This study investigated the immune response and lon…
View article: SAT-358 Corticosterone Treatment during Sepsis Results in a Primary Adrenal Defect in Male Survivors
SAT-358 Corticosterone Treatment during Sepsis Results in a Primary Adrenal Defect in Male Survivors Open
Abnormalities of adrenal gland function have been described in survivors of prolonged critical illness, but whether an acute inflammatory illness such as sepsis causes lasting changes in adrenal function is unknown. Critically ill patients…
View article: Chronic 17β-estradiol pretreatment has pronociceptive effect on behavioral and morphological changes induced by orofacial formalin in ovariectomized rats
Chronic 17β-estradiol pretreatment has pronociceptive effect on behavioral and morphological changes induced by orofacial formalin in ovariectomized rats Open
Our results demonstrate that the chronic 17β-estradiol treatment has strong pronociceptive effect on orofacial formalin-induced inflammatory pain suggesting modulatory action of estradiol on head pain through estrogen receptors, which are …
View article: S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis
S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis Open
Sepsis commonly results in acute and chronic brain dysfunction, which dramatically increases the morbidity associated with this common disease. Chronic brain dysfunction in animal models of sepsis survival is linked to persistent neuroinfl…
View article: Nitroglycerin increases serotonin transporter expression in rat spinal cord but anandamide modulated this effect
Nitroglycerin increases serotonin transporter expression in rat spinal cord but anandamide modulated this effect Open
View article: The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat Open
The primary headache disorders include migraine, which is one of the most frequent neurological disorders, which influences more than 14% of the whole population. Despite the research efforts, its exact pathomechanism is not fully revealed…
View article: A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study
A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study Open