Klaus Berek
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View article: Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis
Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis Open
Background The kappa free light chain (κ-FLC) index is a well-established biomarker in multiple sclerosis (MS). While the prognostic value of the κ-FLC index has been demonstrated in early relapsing–remitting MS, its prognostic value in pr…
View article: Kappa Free Light Chain Index in the Real World—Do We Miss Clinically Relevant Information by Skipping Oligoclonal Banding?
Kappa Free Light Chain Index in the Real World—Do We Miss Clinically Relevant Information by Skipping Oligoclonal Banding? Open
Background No standardized strategy for integrating κ ‐free light chain ( κ ‐FLC) index into routine cerebrospinal fluid (CSF) diagnostics has yet been established. Objective To determine agreement between κ ‐FLC index and CSF‐restricted o…
View article: Early acclimatization to high altitude: Acid–base and fluid balance dynamics during the first 2 days at 3100 m
Early acclimatization to high altitude: Acid–base and fluid balance dynamics during the first 2 days at 3100 m Open
Immediate responses to hypoxia at high altitude are hyperventilation and successive respiratory alkalosis. Alkalosis, in turn, can affect cerebrospinal fluid pH and ventilatory control. The kidneys compensate metabolically for respiratory …
View article: Kappa Free Light Chain Index and Oligoclonal Bands in Varicella Zoster Virus Infection and Neuroborreliosis: A Matter of Timing?
Kappa Free Light Chain Index and Oligoclonal Bands in Varicella Zoster Virus Infection and Neuroborreliosis: A Matter of Timing? Open
Background The diagnosis of Varicella‐zoster virus related neurological disease (VZD) and Lyme neuroborreliosis (LNB) is based on clinical presentation as well as cerebrospinal fluid (CSF) results. Objectives To evaluate and compare the di…
View article: High erythropoietin levels are associated with low neurofilament light levels in simulated high altitude: a further hint for neuroprotection by erythropoietin
High erythropoietin levels are associated with low neurofilament light levels in simulated high altitude: a further hint for neuroprotection by erythropoietin Open
Background Erythropoietin (EPO) plays a crucial role in the early adaption to high altitude and is possibly involved in neuroprotection. Neurofilament light chain (NfL) is an established marker of neuroaxonal damage. Objective To investiga…
View article: The role of age in choosing high-efficacy treatment for multiple sclerosis – an Austrian MS Database study
The role of age in choosing high-efficacy treatment for multiple sclerosis – an Austrian MS Database study Open
Background Treatment strategy for relapsing multiple sclerosis (RMS) is increasingly shifting towards first-line use of high-efficacy DMT (H-DMT). However, DMT efficacy declines with increasing age and the benefit of first line H-DMT at hi…
View article: Kappa free light chain index predicts long-term disease activity and disability accrual in multiple sclerosis
Kappa free light chain index predicts long-term disease activity and disability accrual in multiple sclerosis Open
Background: The prognostic value of κ-free light chain (κ-FLC) index over the long term is unknown. Objectives: The objective of the study was to determine whether κ-FLC index determined at disease onset predicts relapse activity and disab…
View article: Effect of long-term frozen storage on stability of kappa free light chain index
Effect of long-term frozen storage on stability of kappa free light chain index Open
Objectives To investigate whether frozen storage duration influences κ-FLC index. Methods CSF and serum samples of patients with multiple sclerosis collected for routine diagnostic purposes had been stored at −20 °C. κ-FLC and albumin conc…
View article: Hypoxia in multiple sclerosis
Hypoxia in multiple sclerosis Open
View article: Short‐Term Risk Factors for Bone Loss in Multiple Sclerosis: A Prospective Study and Literature Review
Short‐Term Risk Factors for Bone Loss in Multiple Sclerosis: A Prospective Study and Literature Review Open
Background Reduced bone mass and increased osteoporosis risk are common in people with multiple sclerosis (pwMS). The aim of the study was to identify risk factors for short‐term bone loss in MS. Methods This prospective study included 139…
View article: Impact of renal function impairment on kappa free light chain index
Impact of renal function impairment on kappa free light chain index Open
Objectives To investigate whether renal function impacts CSF κ-FLC concentration and/or κ-FLC index. Methods Patients with non-inflammatory neurological diseases were eligible. κ-FLC index was calculated as (CSF κ-FLC/serum κ-FLC)/albumin …
View article: Face exploration, emotion recognition, and emotional enhancement of memory in relapsing-remitting multiple sclerosis
Face exploration, emotion recognition, and emotional enhancement of memory in relapsing-remitting multiple sclerosis Open
Background Recognizing familiar faces and identifying emotions through facial expressions are essential for social functioning. This study aimed to examine whether people with relapsing-remitting multiple sclerosis (PwMS) differ from healt…
View article: Reactive Pleocytosis After Repeated Lumbar Puncture—Implications for Clinical Practice
Reactive Pleocytosis After Repeated Lumbar Puncture—Implications for Clinical Practice Open
Introduction Lumbar puncture (LP) is a routine clinical procedure and, in some cases, is repeatedly performed for diagnostic or therapeutic reasons. The impact of repeated LP on cerebrospinal fluid (CSF) findings is not clear. Objective To…
View article: Faster Decay of Cerebrospinal Fluid Red Blood Cells and Total Protein Predict Good Functional Outcome After Subarachnoid Hemorrhage
Faster Decay of Cerebrospinal Fluid Red Blood Cells and Total Protein Predict Good Functional Outcome After Subarachnoid Hemorrhage Open
Introduction Prognostication after subarachnoid hemorrhage (SAH) is essential to guide clinical management and improve patient care. Objective To investigate whether decay rates of cerebrospinal fluid (CSF) red blood cells (RBC) and total …
View article: The Austrian MS Database and the Austrian MS Cohort – a national effort towards data harmonization and prospective data collection
The Austrian MS Database and the Austrian MS Cohort – a national effort towards data harmonization and prospective data collection Open
Background A variety of disease-modifying therapies (DMTs) are now available for multiple sclerosis (MS), each with distinct efficacy and risk profiles. However, the clinical course of MS varies significantly both within and between indivi…
View article: Retinal thinning differentiates treatment effects in relapsing multiple sclerosis below the clinical threshold
Retinal thinning differentiates treatment effects in relapsing multiple sclerosis below the clinical threshold Open
Objective To investigate retinal layer thinning as a biomarker of disease‐modifying treatment (DMT) effects in relapsing multiple sclerosis (RMS). Methods From an ongoing prospective observational study, we included patients with RMS, who …
View article: Switching from natalizumab to <scp>antiCD20</scp> monoclonal antibodies: Short transition interval is associated with improved outcome
Switching from natalizumab to <span>antiCD20</span> monoclonal antibodies: Short transition interval is associated with improved outcome Open
Objective To investigate the impact of transition interval length when switching from natalizumab (NTZ) to anti‐CD20 monoclonal antibodies (antiCD20) on recurrent disease activity and safety in relapsing multiple sclerosis (RMS). Methods A…
View article: Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis
Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis Open
View article: Neurofilament Light Chain Is Associated With Acute Mountain Sickness
Neurofilament Light Chain Is Associated With Acute Mountain Sickness Open
Background Neurological symptoms are common in acute mountain sickness (AMS); however, the extent of neuroaxonal damage remains unclear. Neurofilament light chain (NfL) is an established blood biomarker for neuroaxonal damage. Objective To…
View article: Cerebrospinal fluid red blood cells and total protein are associated with clinical outcome in spontaneous subarachnoid hemorrhage
Cerebrospinal fluid red blood cells and total protein are associated with clinical outcome in spontaneous subarachnoid hemorrhage Open
Background and Purpose Prognostication in patients with spontaneous subarachnoid hemorrhage (SAH) can be challenging. The aim of this study was to assess whether cerebrospinal fluid (CSF) red blood cell (RBC) count and total protein (TP) c…
View article: Retinal layer thinning for monitoring disease-modifying treatment in relapsing multiple sclerosis—Evidence for applying a rebaselining concept
Retinal layer thinning for monitoring disease-modifying treatment in relapsing multiple sclerosis—Evidence for applying a rebaselining concept Open
Background: Employing a rebaselining concept may reduce noise in retinal layer thinning measured by optical coherence tomography (OCT). Methods: From an ongoing prospective observational study, we included patients with relapsing multiple …
View article: Association of Complement Factors With Disability Progression in Primary Progressive Multiple Sclerosis
Association of Complement Factors With Disability Progression in Primary Progressive Multiple Sclerosis Open
Proteins involved in the activation of early complement cascades play a role in disability progression as risk (elevated serum C3a/C3 ratio) or protective (elevated CSF C1q) factors after 6 or more years of follow-up in patients with PPMS.…
View article: Olfactory threshold as a biomarker of long-term relapse activity in multiple sclerosis
Olfactory threshold as a biomarker of long-term relapse activity in multiple sclerosis Open
OT is a potential surrogate marker for long-term inflammatory disease activity and DMT failure in MS.
View article: Sex impacts treatment decisions in multiple sclerosis
Sex impacts treatment decisions in multiple sclerosis Open
View article: Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study
Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study Open
Background Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS). Objective To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressiv…
View article: Subarachnoid haemorrhage or traumatic lumbar puncture. Differentiation by cerebrospinal fluid parameters in a multivariable approach
Subarachnoid haemorrhage or traumatic lumbar puncture. Differentiation by cerebrospinal fluid parameters in a multivariable approach Open
Lumbar puncture (LP) is recommended in patients with thunderclap headache and negative computed tomography to rule out spontaneous subarachnoid haemorrhage (SAH). Blood contamination of cerebrospinal fluid (CSF) due to traumatic LP poses a…
View article: Odour discrimination and identification as a biomarker of long-term disability worsening in multiple sclerosis
Odour discrimination and identification as a biomarker of long-term disability worsening in multiple sclerosis Open
Background: Odour discrimination and identification (DI) are markers associated with disability worsening and neuroaxonal damage in multiple sclerosis (MS). Objective: The main objective of this research is to investigate whether longitudi…
View article: Diagnostic Performance of Adding the Optic Nerve Region Assessed by Optical Coherence Tomography to the Diagnostic Criteria for Multiple Sclerosis
Diagnostic Performance of Adding the Optic Nerve Region Assessed by Optical Coherence Tomography to the Diagnostic Criteria for Multiple Sclerosis Open
This study provides Class II evidence that adding the optic nerve as determined by OCT as a fifth DIS criterion to the 2017 McDonald criteria improves diagnostic accuracy.
View article: Immune profiling in multiple sclerosis: a single-center study of 65 cytokines, chemokines, and related molecules in cerebrospinal fluid and serum
Immune profiling in multiple sclerosis: a single-center study of 65 cytokines, chemokines, and related molecules in cerebrospinal fluid and serum Open
Introduction The understanding of the pathophysiology of multiple sclerosis (MS) has evolved alongside the characterization of cytokines and chemokines in cerebrospinal fluid (CSF) and serum. However, the complex interplay of pro- and anti…
View article: Screening for osteoporosis in people with MS: A new risk score
Screening for osteoporosis in people with MS: A new risk score Open
This risk score enables individual screening recommendation for pwMS and, subsequently, early prevention of osteoporosis which probably should result in reduction of fractures and morbidity.