Klaus Deckmann
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View article: Tuft cells trigger neurogenic inflammation in the urethra
Tuft cells trigger neurogenic inflammation in the urethra Open
Cholinergic urethral tuft cells (UTCs) are regarded as sentinels of microbial products in the urogenital tract, initiating reflex micturition as a protective mechanism. We here hypothesize that acetylcholine released by stimulated UTC lead…
View article: Multiple jejunal diverticulosis, from an anatomical and histological view: A case report
Multiple jejunal diverticulosis, from an anatomical and histological view: A case report Open
BACKGROUND Here, we report a case of jejunal diverticulosis from an anatomical and histological view. During the “Gross Anatomy course,” we found multiple jejunal diverticula along a total length of 208 cm of intestine. CASE SUMMARY After …
View article: Tas1R3 Dependent and Independent Recognition of Sugars in the Urethra and the Role of Tuft Cells in this Process (Adv. Biology 6/2024)
Tas1R3 Dependent and Independent Recognition of Sugars in the Urethra and the Role of Tuft Cells in this Process (Adv. Biology 6/2024) Open
Urinary Tract Infection Increased sugar concentrations display risk factors for infections. Article number 2400117 by Klaus Deckmann and co-workers clarifies sugar monitoring in the urethra. Urethral tuft cells (UTC) are sentinels monitori…
View article: Tas1R3 Dependent and Independent Recognition of Sugars in the Urethra and the Role of Tuft Cells in this Process
Tas1R3 Dependent and Independent Recognition of Sugars in the Urethra and the Role of Tuft Cells in this Process Open
Increased sugar concentrations on mucosal surfaces display risk factors for infections. This study aims to clarify sugar monitoring in the urethra. Urethral tuft cells (UTC) are known sentinels monitoring the urethral lumen for potentially…
View article: Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters
Cysteinyl leukotrienes and acetylcholine are biliary tuft cell cotransmitters Open
The gallbladder stores bile between meals and empties into the duodenum upon demand and is thereby exposed to the intestinal microbiome. This exposure raises the need for antimicrobial factors, among them, mucins produced by cholangiocytes…
View article: Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice
Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice Open
View article: Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides
Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides Open
View article: ENaC in Cholinergic Brush Cells
ENaC in Cholinergic Brush Cells Open
Cholinergic polymodal chemosensory cells in the mammalian urethra (urethral brush cells = UBC) functionally express the canonical bitter and umami taste transduction signaling cascade. Here, we aimed to determine whether UBC are functional…
View article: XXVIIth Annual Meeting of the European Chemoreception Research Organization, ECRO 2017
XXVIIth Annual Meeting of the European Chemoreception Research Organization, ECRO 2017 Open
Learning obesity biology from man
View article: Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells <i>via</i> negative feedback
Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells <i>via</i> negative feedback Open
We have recently identified a cholinergic chemosensory cell in the urethral epithelium, urethral brush cell (UBC), that, upon stimulation with bitter or bacterial substances, initiates a reflex detrusor activation. Here, we elucidated chol…