Klaus Hoeffler
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View article: Advances in Xenotransplantation: Evaluation of αGal-KO Porcine Livers and Lungs Using Normothermic Machine Perfusion in a Collaborative Perfusion Hub
Advances in Xenotransplantation: Evaluation of αGal-KO Porcine Livers and Lungs Using Normothermic Machine Perfusion in a Collaborative Perfusion Hub Open
Recently, initial clinical experience has been gained with the xenotransplantation of pig organs such as heart and kidney into terminally ill human patients in an effort to overcoming organ shortage. Here, we investigated the use of normot…
View article: Cell therapy with human iPSC-derived cardiomyocyte aggregates leads to efficient engraftment and functional recovery after myocardial infarction in non-human primates
Cell therapy with human iPSC-derived cardiomyocyte aggregates leads to efficient engraftment and functional recovery after myocardial infarction in non-human primates Open
Background Functionally coupled large myocardial grafts and a remarkable improvement of heart function in nonhuman primate models of myocardial infarction have been reported after transplantation of human embryonic stem cell-derived cardio…
View article: 316.2: Long term study of decellularized and glycan-modified GGTA1-KO porcine heart valves implanted into baboons
316.2: Long term study of decellularized and glycan-modified GGTA1-KO porcine heart valves implanted into baboons Open
Introduction: Decellularized heart valves (DHV) have emerged as truly regenerative material that can be actively repopulated with cells and remodeled upon orthotopic implantation by the recipient. However, the limited availability of small…
View article: Supplementary Material for: Left Ventricular Wall Reconstruction with Autologous Vascularized Gastric Graft in a Porcine Pilot Model
Supplementary Material for: Left Ventricular Wall Reconstruction with Autologous Vascularized Gastric Graft in a Porcine Pilot Model Open
Introduction: Surgical replacement of dysfunctional cardiac muscle with regenerative tissue is an important option to combat heart failure. But current available myocardial prostheses like a Dacron or a pericardium patch neither have a reg…
View article: Decellularization combined with enzymatic removal of N‐linked glycans and residual DNA reduces inflammatory response and improves performance of porcine xenogeneic pulmonary heart valves in an ovine in vivo model
Decellularization combined with enzymatic removal of N‐linked glycans and residual DNA reduces inflammatory response and improves performance of porcine xenogeneic pulmonary heart valves in an ovine in vivo model Open
Background Limited availability of decellularized allogeneic heart valve substitutes restricts the clinical application thereof. Decellularized xenogeneic valves might constitute an attractive alternative; however, increased immunological …
View article: Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse Open
The use of extracorporeal membrane oxygenation (ECMO) has increased substantially in recent years. ECMO has become a reliable and effective therapy for acute as well as end-stage lung diseases. With the increase in clinical demand and prol…
View article: Prediction of transplant outcome after 24-hour ex vivo lung perfusion using the Organ Care System in a porcine lung transplantation model
Prediction of transplant outcome after 24-hour ex vivo lung perfusion using the Organ Care System in a porcine lung transplantation model Open
Ex vivo lung perfusion (EVLP) has become routine practice in lung transplantation. Still, running periods exceeding 12 hours have not been undertaken clinically to date, and it remains unclear how the perfusion solution for extended runnin…
View article: Treatment of infected lungs by ex vivo perfusion with high dose antibiotics and autotransplantation: A pilot study in pigs
Treatment of infected lungs by ex vivo perfusion with high dose antibiotics and autotransplantation: A pilot study in pigs Open
The emergence of multi-drug resistant bacteria threatens to end the era of antibiotics. Drug resistant bacteria have evolved mechanisms to overcome antibiotics at therapeutic doses and further dose increases are not possible due to systemi…
View article: Decellularized mitral valve in a long-term sheep model†
Decellularized mitral valve in a long-term sheep model† Open
Surgical implantation of DMV is feasible and results in good early graft function. Additional in vivo investigations are required to minimize the procedure-related complications and to increase the reproducibility of surgical implantation.…
View article: Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine
Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine Open
Solid organs may differ in their potential to induce and maintain a state of donor-specific tolerance. Previously, we induced stable immunological tolerance in a lung transplantation model in miniature swine. Here, we wished to transfer th…
View article: Engineering of small diameter tubular compacted fibrin matrices
Engineering of small diameter tubular compacted fibrin matrices Open
Fibrin is widely used in different approaches of tissue engineering. Nevertheless, poor biomechanical strength restricts its use namely in cardiovascular tissue engineering. We have recently developed a novel moulding technique for the gen…
View article: Aortic valve replacement with sutureless prosthesis: better than root enlargement to avoid patient–prosthesis mismatch?
Aortic valve replacement with sutureless prosthesis: better than root enlargement to avoid patient–prosthesis mismatch? Open
Although the sutureless valve patients received significantly more concomitant procedures, all operation-associated times were significantly shorter. Despite sutureless valve patients being older, the 30-day mortality and survival rates we…