Explanipedia

Protocol for the AFTERHERNIA Project: patient-reported outcomes of groin and ventral hernia repair Open

Anders Gram‐Hanssen, Jason Joe Baker, Hugin Reistrup, Klaus Kaae Andersen, Jacob Rosenberg · 2025

Purpose The AFTERHERNIA Project aims to shift the focus of hernia surgery towards patient-reported outcomes by examining the impact of surgical methods and long-term complications on a national level. Groin and ventral hernia repairs are c…

Thiopurines and the Risk of Cancer in Patients With Inflammatory Bowel Disease and Reference Individuals Without Inflammatory Bowel Disease: A Danish Nationwide Cohort Study (1996-2018) Open

Mads Damsgaard Wewer, Gasper Letnar, Klaus Kaae Andersen, Mikkel Malham, Vibeke Wewer , et al. · 2024

Thiopurines were associated with increased hazard of cancer, especially when used in combination therapy in the elderly. The hazard increased by 36% when patients were exposed to thiopurines for more than 5 years. Reassuringly, the hazard …

P1166 Thiopurines and Risk of Cancer in Patients with Inflammatory Bowel Disease -A Danish Nationwide Cohort study 1996-2018 Open

Mads Damsgaard Wewer, Gasper Letnar, Klaus Kaae Andersen, Mikkel Malham, Vibeke Wewer , et al. · 2024

Background Thiopurines are frequently used in patients with inflammatory bowel disease (IBD). The aim of this study was to assess the cancer risk of thiopurine monotherapy and thiopurine in combination with biologics compared to unexposed …

Diagnostic Workup, Treatment Patterns, and Clinical Outcomes in Early-Stage IB–IIIA Non-Small-Cell Lung Cancer Patients in Denmark Open

Ebbe Meldgaard Uldbjerg, Lars Ringgaard, Klaus Kaae Andersen, Line Elmerdahl Frederiksen, Aleksandar Jovanović , et al. · 2023

Despite recent improvements in early-stage non-small-cell lung cancer (NSCLC), disease relapse remains challenging. Moreover, real-world evidence on long-term follow-up of disease-free survival (DFS) and recurrence patterns in a large, uns…

Improved overall survival for Stage III NSCLC patients treated with curative-intended therapy from 2010 to 2018–a cohort study in Denmark Open

Peter Meldgaard, Michael Kristensen, Simona Conte, Klaus Kaae Andersen, Aleksander Jovanovic , et al. · 2023

Stage III NSCLC is a heterogeneous disease as regards patient and clinical characteristics, multiple treatment options, and outcomes. Age, disease staging, performance status, and comorbidity, as well as MDT evaluation and matching treatme…

Cancer in Patients With Familial Adenomatous Polyposis: A Nationwide Danish Cohort Study With Matched Controls Open

John Gásdal Karstensen, Steffen Bülow, Helle Højen, Anne Marie Jelsig, Niels Jespersen , et al. · 2023

Despite an absolute reduction in the risk of developing cancer among patients with FAP, the risk remained significantly higher than for the background population due to colorectal, pancreatic, and duodenal/small-bowel cancers.

A nationwide observational study in heavily pretreated metastatic HER2-positive breast cancer patients Open

Asbjørn Due, Tobias Berg, Maj‐Britt Jensen, Sophie Yammeni, Lone Marie Volmer , et al. · 2023

In this real-world study, we found that patients were treated with a wide variety of anti-cancer agents with modest efficacy. However, patients in this study did not have access to newer therapies like tucatinib and T-DXd.

Long-term treatment patterns and survival in metastatic breast cancer by intrinsic subtypes – an observational cohort study in Sweden Open

Henrik Lindman, Fredrik Wiklund, Klaus Kaae Andersen · 2022

Background Longitudinal, real-world data on the management of metastatic breast cancer is increasingly relevant to understand breast cancer care in routine clinical practice. Yet such data are scarce, particularly beyond second- and third-…

School performance of children with neurofibromatosis 1: a nationwide population-based study Open

Karoline Doser, F. Belmonte, Klaus Kaae Andersen, John R. Østergaard, Hanne Hove , et al. · 2022

Real‐life data on treatment and outcomes in advanced ovarian cancer: An observational, multinational cohort study (<span>RESPONSE</span> trial) Open

Christian Marth, Miguel Henriques Abreu, Klaus Kaae Andersen, Karoliina Aro, Maria de Lurdes Batarda , et al. · 2022

Background This study aimed to describe the treatment strategies and outcomes for women with newly diagnosed advanced high‐grade serous or endometrioid ovarian cancer (OC). Methods This observational study collected real‐world medical reco…

Risk of New Primary Cancer in Patients with Posterior Uveal Melanoma: A National Cohort Study Open

Mette Bagger, Vanna Albieri, Tine Gadegaard Hindsø, Karin Wadt, Steffen Heegaard , et al. · 2022

Background: Studies on the risk of new primary cancer in patients with posterior uveal melanoma (UM) have produced conflicting results, and the role of socioeconomic status (SES) is unknown. The purpose of this population-based matched coh…

EGFR-mutation testing and TKI treatment patterns in locally advanced and metastatic NSCLC in Norway – A nationwide retrospective cohort study Open

Åslaug Helland, Klaus Kaae Andersen, Tor Åge Myklebust, Tom Børge Johannesen, Jørgen Aarøe , et al. · 2022

Despite increased test rates over the study period, in Norway, a significant proportion of patients with non-squamous metastatic NSCLC are still not tested for EGFR. To maximize the identification of eligible patients for targeted therapie…

Accumulation of Disadvantages Across Multiple Domains Amongst Subgroups of Children of Parents With Schizophrenia or Bipolar Disorder: Clustering Data from the Danish High Risk and Resilience Study VIA 7 Open

Mette Falkenberg Krantz, Ditte Ellersgaard, Klaus Kaae Andersen, Nicoline Hemager, Camilla Jerlang Christiani , et al. · 2022

Objective Children with familial high-risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) are frequently affected in a range of domains known to be precursors of severe mental illness. No previous studies have gathered known precur…

Genome-wide by Environment Interaction Study of Stressful Life Events and Hospital-Treated Depression in the iPSYCH2012 Sample Open

Nis P. Suppli, Klaus Kaae Andersen, Esben Agerbo, Veera M. Rajagopal, Vivek Appadurai , et al. · 2021

Genome-wide by environment interaction study of stressful life events and hospital-treated depression in the iPSYCH2012 sample Open

Nis P. Suppli, Klaus Kaae Andersen, Esben Agerbo, Veera M. Rajagopal, Vivek Appadurai , et al. · 2021

Researchers have long investigated a hypothesized interaction between genetic risk and stressful life events in the etiology of depression, but studies on the topic have yielded inconsistent results. We conducted a genome-wide environment …

Posterior uveal melanoma incidence and survival by AJCC tumour size in a 70‐year nationwide cohort Open

Isabel Guida Smidt-Nielsen, Mette Bagger, Steffen Heegaard, Klaus Kaae Andersen, Jens Folke Kiilgaard · 2021

Purpose While early treatment of posterior uveal melanoma can save the eye, the effect of early treatment on survival remains unknown. Therefore, we aimed to determine whether the tumour size at diagnosis has changed over time, and if this…

405 Real-life response to standard of care in advanced ovarian cancer – an observational multi-national cohort study (RESPONSE) Open

Christian Marth, Heini Lassus, Kristina Lindemann, Els Van Nieuwenhuyen, Anne Weng Ekmann‐Gade , et al. · 2020

Introduction/Background Recent randomized clinical trials have demonstrated convincing effects of integrating PARP inhibitors (PARPi) and combination of PARPi + bevacizumab (anti-VEGF) into first line (1L) treatment of selected groups of a…

Adverse health behaviours in long-term testicular cancer survivors: a Danish nationwide study Open

Michael Kreiberg, Mikkel Bandak, Jakob Lauritsen, Thomas Wagner, Josephine Rosenvilde , et al. · 2020

We identified smoking cessation as primary target for intervention studies in testicular cancer survivors. The effect of smoking cessation interventions as part of treatment should be investigated. Whether drug-based intervention is effect…

REAL-LIFE RESPONSE TO STANDARD OF CARE IN ADVANCED OVARIAN CANCER – AN OBSERVATIONAL MULTI-NATIONAL COHORT STUDY (RESPONSE) Open

Klaus Kaae Andersen · 2020

The influence of marital status and partner concordance on participation in colorectal cancer screening Open

Mie Agermose Gram, Christina Therkildsen, Rebecca B. Clarke, Klaus Kaae Andersen, Lina Steinrud Mørch , et al. · 2020

Background Colorectal cancer screening program using a fecal immunochemical test aims to reduce morbidity and mortality through early detection. Although screening participation is free-of-charge, almost 40% of the invited individuals choo…

Risk of Renal Cell Carcinoma Associated with Calcium Channel Blockers Open

Kasper Bruun Kristensen, Laurel A. Habel, Joshua J. Gagne, Søren Friis, Klaus Kaae Andersen , et al. · 2020

Background: We examined whether the apparent association between renal cell carcinoma (RCC) and use of dihydropyridine calcium channel blockers (CCBs) was explained by confounding by indication since hypertension, the main indication for C…

Risk of late health effects after soft-tissue sarcomas in childhood – a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme Open

Filippa Nyboe Norsker, Cristina Boschini, Catherine Rechnitzer, Anna Sällfors Holmqvist, Laufey Tryggvadóttír , et al. · 2020

In the 1960s only 1/3 of children with soft-tissue sarcomas survived, however with improved treatments survival today has reached 70%. Given the previous poor survival and the rarity of soft-tissue sarcomas, the risk of somatic late effect…

Do repeated transurethral procedures under general anesthesia influence mortality in patients with non-invasive urothelial bladder cancer? A Danish national cohort study Open

Marie Schmidt Erikson, Astrid Petersen, Klaus Kaae Andersen, Frederik Krogsdal Jacobsen, Karin Mogensen , et al. · 2020

Purpose: To investigate the effect of repeated transurethral procedures under general anesthesia on overall mortality in patients with non-invasive bladder cancer.Materials and methods: All Danish residents with non-invasive …

Occult primary brain cancers manifesting in the aftermath of ischaemic and haemorrhagic stroke Open

Klaus Kaae Andersen, Anne Julie Tybjerg, Alejandro Daniel Babore, Tom Skyhøj Olsen · 2020

Introduction Symptoms of occult brain cancer may mimic stroke. Misdiagnosis may lead to improper treatment and delayed diagnosis. We characterised strokes associated with occult primary brain cancer and determined risk that ischaemic and h…

Use of primary health care and participation in colorectal cancer screening – a Danish national register-based study Open

Rebecca B. Clarke, Christina Therkildsen, Mie Agermose Gram, Klaus Kaae Andersen, Lina Steinrud Mørch , et al. · 2020

Colorectal cancer is the third most common cancer type and the second most common cancer-related death worldwide [1]. High incidence and mortality of colorectal cancer and effective screening tools...

Multisystem burden of neurofibromatosis 1 in Denmark: registry- and population-based rates of hospitalizations over the life span Open

Line Kenborg, Anne Katrine Duun‐Henriksen, Susanne Oksbjerg Dalton, Pernille Envold Bidstrup, Karoline Doser , et al. · 2020

DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy Open

Pietri Puustinen, Anne Keldsbo, Elisabeth Corcelle–Termeau, Kevin R. W. Ngoei, Stine Lauritzen Sønder , et al. · 2020

Macroautophagy/autophagy is a central component of the cytoprotective cellular stress response. To enlighten stress-induced autophagy signaling, we screened a human kinome siRNA library for regulators of autophagic flux in MCF7 human breas…

Risk of late health effects after soft-tissue sarcomas in childhood – a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia research programme Open

Filippa Nyboe Norsker, Cristina Boschini, Catherine Rechnitzer, Anna Sällfors Holmqvist, Laufey Tryggvadóttír , et al. · 2020

In the 1960s only 1/3 of children with soft-tissue sarcomas survived, however with improved treatments survival today has reached 70%. Given the previous poor survival and the rarity of soft-tissue sarcomas, the risk of somatic late effect…

Follow-up strategies following completion of primary cancer treatment in adult cancer survivors Open

Beverley Lim Høeg, Pernille Envold Bidstrup, Randi V. Karlsen, Anne Sofie Friberg, Vanna Albieri , et al. · 2019

Evidence regarding the effectiveness of the different follow-up strategies varies substantially. Less intensive follow-up may make little or no difference to overall survival but probably delays detection of recurrence. However, as we did …

Educational level and first-time PSA testing in general practice Open

Caroline Sophie Lerhmann-Lerche, Signe Benzon Larsen, Ingelise Andersen, Lau Caspar Thygesen, Klaus Kaae Andersen , et al. · 2019

Introduction: Different patterns in the use of prostate-specific antigen (PSA) testing might explain socioeconomic differences in prostate cancer incidence and mortality. We examined the association between socioeconomic position, m…

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