Klaus Kopka
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View article: Investigation of a GPC-3-addressing peptide as potential radioligand for PET imaging of HCC
Investigation of a GPC-3-addressing peptide as potential radioligand for PET imaging of HCC Open
View article: Towards an Optimized Production and Purification Method for 197(m)Hg
Towards an Optimized Production and Purification Method for 197(m)Hg Open
View article: Potential of 133La as a PET surrogate to new and established therapeutic radiometals like 135La, 90Y and 177Lu: a case study on [133La]La-CHX-A''-DTPA-cetuximab stability and in vitro properties
Potential of 133La as a PET surrogate to new and established therapeutic radiometals like 135La, 90Y and 177Lu: a case study on [133La]La-CHX-A''-DTPA-cetuximab stability and in vitro properties Open
View article: Radioiodinated Carborane-based Indomethacin-Derivatives as Cyclooxygenase-2 Radiotracers
Radioiodinated Carborane-based Indomethacin-Derivatives as Cyclooxygenase-2 Radiotracers Open
View article: Human renal cell co-culture model for [18F]FDG transport examination with the option to investigate renal radiotracer retention
Human renal cell co-culture model for [18F]FDG transport examination with the option to investigate renal radiotracer retention Open
View article: Development of an HCAR1 radiotracer
Development of an HCAR1 radiotracer Open
View article: Preclinical Evaluation of 203Pb- and 212Pb-Labeled mcp-PSMA Ligands for Radionuclide Theranostics of Prostate Cancer
Preclinical Evaluation of 203Pb- and 212Pb-Labeled mcp-PSMA Ligands for Radionuclide Theranostics of Prostate Cancer Open
View article: In Vitro Characterization of the Published Glypican-3-Targeting Peptide TJ12P2 Reveals a Lack of Specificity and Potency
In Vitro Characterization of the Published Glypican-3-Targeting Peptide TJ12P2 Reveals a Lack of Specificity and Potency Open
Background/Objectives: The cell surface proteoglycan glypican-3 (GPC3) is reportedly overexpressed in hepatocellular carcinoma (HCC) tissues, but not in benign liver tissues, rendering this protein a potential target for radionuclide thera…
View article: Copper-mediated radiofluorination: A battle against protodeboronation
Copper-mediated radiofluorination: A battle against protodeboronation Open
View article: Development of four new diaza macrocycles with regioisomeric diazine carboxylic acid sidearms for stable complexation of lanthanum-133, actinium-225 and lead-203/-212 with focus on barium-131 and radium-223/-224
Development of four new diaza macrocycles with regioisomeric diazine carboxylic acid sidearms for stable complexation of lanthanum-133, actinium-225 and lead-203/-212 with focus on barium-131 and radium-223/-224 Open
View article: “Precision on Two Wheels”─Structural Refinement of <sup>64</sup> Cu- and <sup>68</sup> Ga-Labeled Bicyclic Peptides Targeting Nectin-4 for Improved Tumor Imaging: From Preclinical Development to First-in-Human Application
“Precision on Two Wheels”─Structural Refinement of <sup>64</sup> Cu- and <sup>68</sup> Ga-Labeled Bicyclic Peptides Targeting Nectin-4 for Improved Tumor Imaging: From Preclinical Development to First-in-Human Application Open
The cell adhesion protein nectin-4 emerged as a valid therapeutic target for antibody- and peptide-drug conjugates in cancer. To support patient stratification for such targeted therapies, there is a clinical need for molecular imaging age…
View article: Highlight selection of radiochemistry and radiopharmacy developments by editorial board
Highlight selection of radiochemistry and radiopharmacy developments by editorial board Open
View article: The hydrogenation side-reaction in copper-mediated radiofluorination
The hydrogenation side-reaction in copper-mediated radiofluorination Open
Background Copper-mediated radiofluorination (CMRF) is a breakthrough in 18 F-radiochemistry, enabling 18 F incorporation into molecules even at electron-rich aromatic positions. In recent years, several improved protocols have been report…
View article: From Inhibitors to PET: SAR-Based Development of [<sup>18</sup>F]SK60 for mIDH1 Imaging
From Inhibitors to PET: SAR-Based Development of [<sup>18</sup>F]SK60 for mIDH1 Imaging Open
Mutations in isocitrate dehydrogenase 1/2 (mIDH1/2) are clinically significant biomarkers for diagnosis, prognosis, and therapy in cancer. To advance the noninvasive molecular imaging of mIDH1, we aim to develop a positron emission tomogra…
View article: PET and SPECT Tracer Development via Copper-Mediated Radiohalogenation of Divergent and Stable Aryl-Boronic Esters
PET and SPECT Tracer Development via Copper-Mediated Radiohalogenation of Divergent and Stable Aryl-Boronic Esters Open
Background/Objectives: Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are highly sensitive clinical imaging modalities, frequently employed in conjunction with magnetic resonance imaging (MRI) or …
View article: It’s a match: use of the radionuclide theranostic pair 133La/225Ac for the radiopharmacological characterization of EGFR-targeted single-domain antibodies
It’s a match: use of the radionuclide theranostic pair 133La/225Ac for the radiopharmacological characterization of EGFR-targeted single-domain antibodies Open
Background Targeted alpha therapy represents an advanced and rapidly evolving form of precision cancer treatment with increasing importance in recent years. The alpha-emitter 225Ac plays a key role in this clinical development due to its a…
View article: PET and SPECT Tracer Development via Copper-Mediated Radiohalogenation of Divergent and Stable Aryl Boronic Esters
PET and SPECT Tracer Development via Copper-Mediated Radiohalogenation of Divergent and Stable Aryl Boronic Esters Open
Clinically used imaging modalities such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) are highly sensitive non-invasive imaging modalities utilized in combination with magnetic resonance imagi…
View article: Deciphering the Tumor Uptake of Heterobivalent (SST<sub>2</sub>/Albumin) [<sup>64</sup>Cu]Cu-NODAGA-cLAB-TATEs
Deciphering the Tumor Uptake of Heterobivalent (SST<sub>2</sub>/Albumin) [<sup>64</sup>Cu]Cu-NODAGA-cLAB-TATEs Open
Radioligands with albumin-binding moieties exhibit a great potential for the treatment of tumor diseases owing to the general finding of an increased integral tumor uptake compared to radioligands without such moieties. However, the reason…
View article: Development of [<sup>99m</sup>Tc]TcO-ABX474: Design, Synthesis, and Biological Evaluation of PSMA-Binding Technetium-99m Radioligands for SPECT Imaging of Prostate Cancer
Development of [<sup>99m</sup>Tc]TcO-ABX474: Design, Synthesis, and Biological Evaluation of PSMA-Binding Technetium-99m Radioligands for SPECT Imaging of Prostate Cancer Open
A current global limitation to the timely and equitable patient access to PSMA-based therapies for prostate cancer (PCa) is the insufficient PET capacity for pretreatment imaging. However, the extensive global availability of SPECT cameras…
View article: Preparation of Macrobicyclic Cryptands for Radiometal Complexation
Preparation of Macrobicyclic Cryptands for Radiometal Complexation Open
Macrobicyclic cryptands and especially derivatives with functionalized side arms (picolinate, pyrimidine carboxylate, and bipyridine carboxylate) are able to complex metal ions effectively. In this regard, four new functionalized cryptands…
View article: Development and evaluation of deuterated [18F]JHU94620 isotopologues for the non-invasive assessment of the cannabinoid type 2 receptor in brain
Development and evaluation of deuterated [18F]JHU94620 isotopologues for the non-invasive assessment of the cannabinoid type 2 receptor in brain Open
Background The cannabinoid type 2 receptors (CB2R) represent a target of increasing importance in neuroimaging due to its upregulation under various neuropathological conditions. Previous evaluation of [ 18 F]JHU94620 for the non-invasive …
View article: Enhancing the radionuclide theranostic concept through the radiohybrid approach
Enhancing the radionuclide theranostic concept through the radiohybrid approach Open
The radiohybrid concept: a significant extension of radionuclide theranostics – a fast-growing field in radiopharmaceutical sciences offering personalised and precise treatment options by combining specific diagnosis with targeted endoradi…
View article: Synthesis and Preclinical Evaluation of a Bispecific PSMA-617/RM2 Heterodimer Targeting Prostate Cancer
Synthesis and Preclinical Evaluation of a Bispecific PSMA-617/RM2 Heterodimer Targeting Prostate Cancer Open
Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) have been used for diagnostic molecular imaging/therapy of prostate cancer (PCa). To address tumor heterogeneity, we synthesized and evaluated a bispec…
View article: Combined PET Radiotracer Approach Reveals Insights into Stromal Cell-Induced Metabolic Changes in Pancreatic Cancer In Vitro and In Vivo
Combined PET Radiotracer Approach Reveals Insights into Stromal Cell-Induced Metabolic Changes in Pancreatic Cancer In Vitro and In Vivo Open
Background/Objective Pancreatic stellate cells (PSCs) in pancreatic adenocarcinoma (PDAC) are producing extracellular matrix, which promotes the formation of a dense fibrotic microenvironment. This makes PDAC a highly heterogeneous tumor-s…
View article: Highlight selection of radiochemistry and radiopharmacy developments by editorial board
Highlight selection of radiochemistry and radiopharmacy developments by editorial board Open
Background The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development. Main body This selection of highlights provid…
View article: Cyclohexanediamine Triazole (CHDT) Functionalization Enables Labeling of Target Molecules with Al<sup>18</sup>F/<sup>68</sup>Ga/<sup>111</sup>In
Cyclohexanediamine Triazole (CHDT) Functionalization Enables Labeling of Target Molecules with Al<sup>18</sup>F/<sup>68</sup>Ga/<sup>111</sup>In Open
The Al18F-labeling approach offers a one-step access to radiofluorinated biomolecules by mimicking the labeling process for radiometals. Although these labeling conditions are considered to be mild compared to classic radiofluor…
View article: Scalability study on [133La]LaCl3 production with a focus on potential clinical applications
Scalability study on [133La]LaCl3 production with a focus on potential clinical applications Open
Background In recent years, targeted alpha therapy has gained importance in the clinics, and in particular, the alpha-emitter 225 Ac plays a fundamental role in this clinical development. Nevertheless, depending on the chelating system no …
View article: Towards the Stable Binding of Mercury: Synthesis and Functionalization of Dibenzyldiazabicyclononane Scaffolds
Towards the Stable Binding of Mercury: Synthesis and Functionalization of Dibenzyldiazabicyclononane Scaffolds Open
A universally applicable synthesis route for the preparation of functionalized diazabicyclononane compounds was elaborated starting from a readily available 1,5‐diphenyl‐3,7‐diazabicyclo[3.3.1] nonan‐9‐ol by alkylation of both secondary am…
View article: Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1) Open
View article: Preparation of HOPO-containing lariate ethers based on the diaza-18-crown-6 scaffold
Preparation of HOPO-containing lariate ethers based on the diaza-18-crown-6 scaffold Open
Cyclic and acyclic ligands containing the hydroxypyridinone (HOPO) moiety as donor group are known as strong coordinating compounds for a wide variety of metal ions. Based on the diaza-crown[18]ether Kryptofix K22, five different tendentat…