Klemens Ablasser
YOU?
Author Swipe
View article: Left ventricular global longitudinal strain and diagnostic yield of genetic testing in hypertrophic cardiomyopathy in a multicenter registry analysis
Left ventricular global longitudinal strain and diagnostic yield of genetic testing in hypertrophic cardiomyopathy in a multicenter registry analysis Open
View article: Patients with paroxysmal atrial fibrillation undergoing left atrial appendage closure
Patients with paroxysmal atrial fibrillation undergoing left atrial appendage closure Open
Introduction There is limited evidence regarding outcome in patients with paroxysmal vs. persistent atrial fibrillation (AF) undergoing left atrial appendage closure (LAAC). Methods A retrospective analysis from a multicentre registry incl…
View article: Ambient Temperature and the Frequency of Subsequent Heart Failure Decompensations in an Emergency Department
Ambient Temperature and the Frequency of Subsequent Heart Failure Decompensations in an Emergency Department Open
Background/Objectives: The impact of cold temperature on heart failure (HF) decompensations in continental climate zones is unclear. We aimed to evaluate the association between daily temperature and the subsequent frequency of HF decompen…
View article: Prognostic impact of gait speed, muscle strength and muscle mass in chronic heart failure—A prospective cohort study
Prognostic impact of gait speed, muscle strength and muscle mass in chronic heart failure—A prospective cohort study Open
Aims Heart failure (HF) impairs skeletal muscle mass and function, which contributes to reduced physical performance. We investigated the prognostic impact of gait speed (GS), handgrip strength (HG) and appendicular skeletal muscle index (…
View article: Air Pollution and Myocardial Infarction—A New Smoker’s Paradox?
Air Pollution and Myocardial Infarction—A New Smoker’s Paradox? Open
Background/Objectives: Ambient air pollution is a significant public health concern, known to affect cardiovascular health adversely. Research has identified both long-term and short-term cardiovascular risks associated with various air po…
View article: Left Atrial Appendage Closure in Atrial Fibrillation Patients with Cancer
Left Atrial Appendage Closure in Atrial Fibrillation Patients with Cancer Open
Background: There are limited data about left atrial appendage closure (LAAC) in patients with cancer. We therefore sought to compare the outcome after LAAC in patients with vs. without cancer in a multicentre registry. Methods: In this su…
View article: Impact of SGLT2-Inhibitor Therapy on Survival in Patients with Transthyretin Amyloid Cardiomyopathy: Analysis of a Prospective Registry Study
Impact of SGLT2-Inhibitor Therapy on Survival in Patients with Transthyretin Amyloid Cardiomyopathy: Analysis of a Prospective Registry Study Open
Background: Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) represent a high-risk heart failure population with continued unmet therapeutic needs. Sodium–glucose co-transporter 2 inhibitors (SGLT2i) improve cardiovascular outc…
View article: Impact of empagliflozin on cardiac structure and function assessed by echocardiography after myocardial infarction: a post-hoc sub-analysis of the emmy trial
Impact of empagliflozin on cardiac structure and function assessed by echocardiography after myocardial infarction: a post-hoc sub-analysis of the emmy trial Open
Background Empagliflozin administered after acute myocardial infarction proofed to improve cardiometabolic parameters and biomarkers, but the impact on cardiac function is still largely unknown. The aim of this post-hoc echocardiographic s…
View article: Phenotype clustering of hospitalized high-risk patients with COVID-19 — a machine learning approach within the multicentre, multinational PCHF-COVICAV registry
Phenotype clustering of hospitalized high-risk patients with COVID-19 — a machine learning approach within the multicentre, multinational PCHF-COVICAV registry Open
The ML process has identified three important clinical clusters from hospitalized COVID-19 CV and/or RF patients. The cluster of males with severe CV disease, particularly HF, and multiple RF presenting with increased inflammation had a pa…
View article: The Prognostic Value of Right Ventricular Function in Patients with Chronic Heart Failure—A Prospective Study
The Prognostic Value of Right Ventricular Function in Patients with Chronic Heart Failure—A Prospective Study Open
Background: In patients with stable chronic heart failure with a reduced ejection fraction (HFrEF), left ventricular ejection fraction (LVEF) provides limited prognostic value, especially in patients with moderately to severely reduced LVE…
View article: Impact of the Timing of Mechanical Circulatory Support on the Outcomes in Myocardial Infarction-Related Cardiogenic Shock: Subanalysis of the PREPARE CS Registry
Impact of the Timing of Mechanical Circulatory Support on the Outcomes in Myocardial Infarction-Related Cardiogenic Shock: Subanalysis of the PREPARE CS Registry Open
(1) Background: Mechanical circulatory support (MCS) in myocardial infarction-associated cardiogenic shock is subject to debate. This analysis aims to elucidate the impact of MCS’s timing on patient outcomes, based on data from the PREPARE…
View article: Prevalence and prognostic impact of bone disease in chronic heart failure with reduced ejection fraction
Prevalence and prognostic impact of bone disease in chronic heart failure with reduced ejection fraction Open
Aims Chronic heart failure is associated with a bone‐catabolic state and increases the risk of osteoporosis and fractures. Prospective studies investigating the clinical relevance of bone disease in heart failure are lacking. We aimed to a…
View article: Impact of Mechanical Circulatory Support Timing on Outcomes in Myocardial Infarction-Related Cardiogenic Shock: Subanalysis of the PREPARE CS Registry
Impact of Mechanical Circulatory Support Timing on Outcomes in Myocardial Infarction-Related Cardiogenic Shock: Subanalysis of the PREPARE CS Registry Open
(1) Background: Mechanical circulatory support (MCS) in myocardial infarction associated cardiogenic shock is subject to debate. This analysis aims to elucidate the impact of MCS timing on patient outcomes, based on data from the PREPARE C…
View article: Low-grade systemic inflammation and left ventricular dysfunction in hypertensive compared to non-hypertensive hypertrophic cardiomyopathy
Low-grade systemic inflammation and left ventricular dysfunction in hypertensive compared to non-hypertensive hypertrophic cardiomyopathy Open
This study demonstrates that HTN is associated with indices of low-grade systemic inflammation among HCM patients. Moreover, this analysis indicates that the adverse impact of HTN in HCM patients is a consequence of systemic effects rather…
View article: Outcomes of ECLS-SHOCK Eligibility Criteria Applied to a Real-World Cohort
Outcomes of ECLS-SHOCK Eligibility Criteria Applied to a Real-World Cohort Open
Background: Cardiogenic shock (CS) exhibits high (~50%) in-hospital mortality. The recently published Extracorporeal life Support in Cardiogenic Shock (ECLS-SHOCK) trial demonstrated the neutral effects of the use of veno-arterial extracor…
View article: Comparing indices of systemic inflammation and cardiac phenotype between hypertensive and non-hypertensive hypertrophic cardiomyopathy
Comparing indices of systemic inflammation and cardiac phenotype between hypertensive and non-hypertensive hypertrophic cardiomyopathy Open
Background Arterial hypertension (HTN) is associated with excess mortality in hypertrophic cardiomyopathy (HCM), but underlying mechanisms are largely elusive. Purpose The purpose of this study was to investigate the association between HT…
View article: Physical capacity determines physical and mental health in patients with chronic heart failure - a case control study
Physical capacity determines physical and mental health in patients with chronic heart failure - a case control study Open
Background Chronic heart failure (CHF) is associated with reduced quality of life (QoL), but underlying mechanisms are incompletely understood. In this study we aimed to assess determinants of both physical and mental functioning in patien…
View article: Interleukin-6 plasma levels predict mortality and heart failure events in cardiac transthyretin amyloidosis
Interleukin-6 plasma levels predict mortality and heart failure events in cardiac transthyretin amyloidosis Open
Background Low-grade systemic inflammation is a key component in the pathophysiology of heart failure (HF). In particular, the pleiotropic effects of interleukin-6 (IL-6) signaling are of interest as circulating IL-6 levels are associated …
View article: Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohort
Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohort Open
Pivotal outcome trials targeting heart failure with preserved (HFpEF) and mildly-reduced ejection fraction (HFmrEF) may have excluded patients at highest risk of poor outcomes. We aimed to assess eligibility for HFpEF/HFmrEF outcome trials…
View article: Transesophageal echocardiography‐guided versus fluoroscopy‐guided patent foramen ovale closure: A single center registry
Transesophageal echocardiography‐guided versus fluoroscopy‐guided patent foramen ovale closure: A single center registry Open
Background Percutaneous closure of patent foramen ovale (PFO) is conventionally performed under continuous transesophageal echocardiographic (TEE) guidance. We aimed to evaluate whether a simplified procedural approach, including pure fluo…
View article: Size matters - body size and acute device-implantation failure after LAAC
Size matters - body size and acute device-implantation failure after LAAC Open
Funding Acknowledgements Type of funding sources: None. Introduction Patient-device mismatch in patients undergoing left atrial appendage closure (LAAC) may lead to failure to implant, dislocation, and cardiac tamponade. There is limited d…
View article: Diagnostic Accuracy of Bone Scintigraphy for the Histopathological Diagnosis of Cardiac Transthyretin Amyloidosis—A Retrospective Austrian Multicenter Study
Diagnostic Accuracy of Bone Scintigraphy for the Histopathological Diagnosis of Cardiac Transthyretin Amyloidosis—A Retrospective Austrian Multicenter Study Open
We aimed to ascertain the real-world diagnostic accuracy of bone scintigraphy in combination with free light chain (FLC) assessment for transthyretin (ATTR) cardiac amyloidosis (CA) using the histopathological diagnosis derived from endomy…
View article: Not to Rush—Laboratory Parameters and Procedural Complications in Patients Undergoing Left Atrial Appendage Closure
Not to Rush—Laboratory Parameters and Procedural Complications in Patients Undergoing Left Atrial Appendage Closure Open
Background: As a preventive procedure, minimizing periprocedural risk is crucially important during left atrial appendage closure (LAAC). Methods: We included consecutive patients receiving LAAC at nine centres and assessed the relationshi…
View article: Diagnostic accuracy of amyloid scintigraphy for the histopathological diagnosis of cardiac transthyretin amyloidosis – a retrospective Austrian multicenter study
Diagnostic accuracy of amyloid scintigraphy for the histopathological diagnosis of cardiac transthyretin amyloidosis – a retrospective Austrian multicenter study Open
Background Previous studies indicated that amyloid scintigraphy in combination with free light chain (FLC) assessment yields an excellent diagnostic accuracy for cardiac transthyretin (ATTR) amyloidosis (1). As a consequence, the diagnosis…
View article: Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial
Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial Open
Aims The presence of pulmonary hypertension (PH) severely aggravates the clinical course of heart failure with preserved ejection fraction (HFpEF). To date, neither established heart failure therapies nor pulmonary vasodilators proved bene…
View article: Cohort profile: ‘Biomarkers of Personalised Medicine’ (BioPersMed): a single-centre prospective observational cohort study in Graz/Austria to evaluate novel biomarkers in cardiovascular and metabolic diseases
Cohort profile: ‘Biomarkers of Personalised Medicine’ (BioPersMed): a single-centre prospective observational cohort study in Graz/Austria to evaluate novel biomarkers in cardiovascular and metabolic diseases Open
Purpose Accumulating evidence points towards a close relationship between cardiovascular, endocrine and metabolic diseases. The BioPersMed Study (Biomarkers of Personalised Medicine) is a single-centre prospective observational cohort stud…
View article: Low haemoglobin is associated with increased risk of complications in left atrial appendage closure patients
Low haemoglobin is associated with increased risk of complications in left atrial appendage closure patients Open
Introduction Left atrial appendage closure is associated with a relevant procedural complication rate. Baseline risk factors, such as pre-procedural lab results, may identify patients that develop acute complications. Methods We performed …
View article: Post-processing measurement of left ventricular ejection fraction compared to direct measurement in patients with heart failure with reduced ejection fraction
Post-processing measurement of left ventricular ejection fraction compared to direct measurement in patients with heart failure with reduced ejection fraction Open
Introduction Left ventricular ejection fraction (LVEF) derived from transthoracic echocardiography (TTE) is routinely used to guide therapeutic decisions in patients with heart failure with reduced ejection fraction (HFrEF). However, TTE-b…
View article: Myocardial Deformation Analysis in MYBPC3 and MYH7 Related Sarcomeric Hypertrophic Cardiomyopathy—The Graz Hypertrophic Cardiomyopathy Registry
Myocardial Deformation Analysis in MYBPC3 and MYH7 Related Sarcomeric Hypertrophic Cardiomyopathy—The Graz Hypertrophic Cardiomyopathy Registry Open
Accumulating evidence suggests that individuals with sarcomeric hypertrophic cardiomyopathy (HCM) carrying MYH7 mutations may have a worse prognosis than MYBPC3 mutation carriers. Myocardial deformation analysis is superior to standard ech…
View article: Heart failure in COVID‐19: the multicentre, multinational PCHF‐COVICAV registry
Heart failure in COVID‐19: the multicentre, multinational PCHF‐COVICAV registry Open
Aims We assessed the outcome of hospitalized coronavirus disease 2019 (COVID‐19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaem…