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View article: Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints
Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints Open
In this study, we sought to characterize synovial tissue obtained from individuals with arthralgia and disease-specific auto-antibodies and patients with established rheumatoid arthritis (RA), by applying an integrative multi-omics approac…
View article: Decision letter: CRISPR-based functional genomics in human dendritic cells
Decision letter: CRISPR-based functional genomics in human dendritic cells Open
View article: Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air–liquid interface
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air–liquid interface Open
To the Editor:
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\nThe structure and composition of the bronchial epithelium is altered in respiratory diseases such as COPD and asthma, in which goblet cell hyperplasia and reduced numbers of ciliated cells impair mucociliary clearance. …
View article: Novel Insights into Rheumatoid Arthritis Through Characterisation of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients with Differing Numbers of Swollen Joints
Novel Insights into Rheumatoid Arthritis Through Characterisation of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients with Differing Numbers of Swollen Joints Open
View article: Single-Step, High-Efficiency CRISPR-Cas9 Genome Editing in Primary Human Disease-Derived Fibroblasts
Single-Step, High-Efficiency CRISPR-Cas9 Genome Editing in Primary Human Disease-Derived Fibroblasts Open
Genome editing is a tool that has many applications, including the validation of potential drug targets. However, performing genome editing in low-passage primary human cells with the greatest physiological relevance is notoriously difficu…
View article: Highly efficient genome editing in primary bronchial epithelial cells establishes FOXJ1 as essential for ciliation in human airways
Highly efficient genome editing in primary bronchial epithelial cells establishes FOXJ1 as essential for ciliation in human airways Open
The structure and composition of the bronchial epithelium is altered in respiratory diseases such as COPD and asthma, in which goblet cell hyperplasia and reduced numbers of ciliated cells impair mucociliary clearance. We describe a robust…
View article: Single step, high efficiency CRISPR-Cas9 genome editing in primary human disease-derived fibroblasts
Single step, high efficiency CRISPR-Cas9 genome editing in primary human disease-derived fibroblasts Open
Genome editing is a tool that has many applications including the validation of potential drug targets. However, performing genome editing in low passage, primary human cells with the greatest physiological relevance, is notoriously diffic…
View article: Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs
Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs Open
View article: Hierarchical clustering and principal component analysis of CpG methylation profiles obtained in the F1 reciprocal crosses.
Hierarchical clustering and principal component analysis of CpG methylation profiles obtained in the F1 reciprocal crosses. Open
Dendrograms showing the results of clustering the CpG methylation profiles obtained in each of the F1 animals before (A) and after (C) phasing the read data by parental genotype. The prefix of the phased F1 profiles in (C) denotes the reci…
View article: <i>In silico</i>and<i>in vitro</i>evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization
<i>In silico</i>and<i>in vitro</i>evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization Open
With many safety and technical limitations partly mitigated through chemical modifications, antisense oligonucleotides (ASOs) are gaining recognition as therapeutic entities. The increase in potency realized by 'third generation chemistrie…
View article: The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia
The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia Open