Knut Erik Tollefsen
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View article: Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project
Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project Open
A recent study has suggested that plastics may contain more than 16,000 chemicals, including additives, processing aids, starting substances, intermediates and Non-Intentionally Added Substances. Plastic chemicals are released throughout t…
View article: A multi-tiered workflow for constructing a quantitative adverse outcome pathway network for gamma radiation-induced reproductive inhibition in Lemna minor
A multi-tiered workflow for constructing a quantitative adverse outcome pathway network for gamma radiation-induced reproductive inhibition in Lemna minor Open
While numerous qualitative adverse outcome pathways (AOPs) have been developed to describe the progressive toxicity of ionizing radiation, quantitative AOPs (qAOPs) to detail how effects quantitatively propagate from the initial molecular …
View article: Interactive effects of elevated atmospheric CO2 and UV-B radiation: A multi-level study on marine diatom Skeletonema pseudocostatum
Interactive effects of elevated atmospheric CO2 and UV-B radiation: A multi-level study on marine diatom Skeletonema pseudocostatum Open
Climate change as a result of increases in greenhouse gas emissions, such as CO2, is causing significant alteration in global environmental conditions, including ocean acidification (OA). Although the depletion of the ozone laye…
View article: Quantitative analysis of the polar cod (Boreogadus saida) hepatic proteome highlights interconnected responses in cellular adaptation and defence mechanisms after dietary benzo[a]pyrene exposure
Quantitative analysis of the polar cod (Boreogadus saida) hepatic proteome highlights interconnected responses in cellular adaptation and defence mechanisms after dietary benzo[a]pyrene exposure Open
Increased industrial offshore activities in northern waters raise the question of impact of polycyclic aromatic hydrocarbons (PAHs) on key Arctic marine species. One of these is the ecologically important polar cod (Boreogadus saida), whic…
View article: A Multi-Tiered Workflow for Constructing a Quantitative Adverse Outcome Pathway Network for Gamma Radiation-Induced Reproductive Inhibition in Lemna Minor
A Multi-Tiered Workflow for Constructing a Quantitative Adverse Outcome Pathway Network for Gamma Radiation-Induced Reproductive Inhibition in Lemna Minor Open
View article: Radiation Adverse Outcome pathways (AOPs): examining priority questions from an international horizon-style exercise
Radiation Adverse Outcome pathways (AOPs): examining priority questions from an international horizon-style exercise Open
By addressing the 25 priority questions, it is anticipated that constructed AOPs will have a high level of specificity, making them valuable tools for simplifying and prioritizing complex biological processes for use in developing revised …
View article: Effects of petrogenic pollutants on North Atlantic and Arctic Calanus copepods: From molecular mechanisms to population impacts
Effects of petrogenic pollutants on North Atlantic and Arctic Calanus copepods: From molecular mechanisms to population impacts Open
Oil and gas industries in the Northern Atlantic Ocean have gradually moved closer to the Arctic areas, a process expected to be further facilitated by sea ice withdrawal caused by global warming. Copepods of the genus Calanus hold a key po…
View article: Using a Bayesian Network Model to Predict Risk of Pesticides on Aquatic Community Endpoints in a Rice Field—A Southern European Case Study
Using a Bayesian Network Model to Predict Risk of Pesticides on Aquatic Community Endpoints in a Rice Field—A Southern European Case Study Open
Bayesian network (BN) models are increasingly used as tools to support probabilistic environmental risk assessments (ERAs), because they can better account for uncertainty compared with the simpler approaches commonly used in traditional E…
View article: Predicting Environmental Risks of Pharmaceuticals from Wholesale Data: An Example from Norway
Predicting Environmental Risks of Pharmaceuticals from Wholesale Data: An Example from Norway Open
Environmental risk assessment (ERA) of pharmaceuticals relies on available measured environmental concentrations, but often such data are sparse. Predicted environmental concentrations (PECs), calculated from sales weights, are an attracti…
View article: Age and Synchronization of <i>Daphnia magna</i> Affect Sensitivity to Teflubenzuron in Acute Standardized Toxicity Tests
Age and Synchronization of <i>Daphnia magna</i> Affect Sensitivity to Teflubenzuron in Acute Standardized Toxicity Tests Open
The standard Daphnia sp. acute toxicity test for assessing the adverse effects of chemicals on aquatic invertebrates stipulates the use of neonates that are ≤24 h old (hours post release [hpr]) at the start of the exposure. However, when o…
View article: Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation
Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation Open
While adverse biological effects of acute high-dose ionizing radiation have been extensively investigated, knowledge on chronic low-dose effects is scarce. The aims of the present study were to identify hazards of low-dose ionizing radiati…
View article: Chitin synthase 1 inhibition leading to mortality
Chitin synthase 1 inhibition leading to mortality Open
This Adverse Outcome Pathway (AOP) describes the linkage between Chitin synthase 1 inhibition and mortality in arthropods. In order to grow and develop, arthropods need to shed their exoskeleton (or cuticle) periodically and replace it wit…
View article: A review of quantitative structure-activity relationship modelling approaches to predict the toxicity of mixtures
A review of quantitative structure-activity relationship modelling approaches to predict the toxicity of mixtures Open
Exposure to chemicals generally occurs in the form of mixtures. However, the great majority of the toxicity data, upon which chemical safety decisions are based, relates only to single compounds. It is currently unfeasible to test a fully …
View article: Understanding Adverse Biological Effect Predictions Using Knowledge Graphs
Understanding Adverse Biological Effect Predictions Using Knowledge Graphs Open
Extrapolation of adverse biological (toxic) effects of chemicals is an important contribution to expand available hazard data in (eco)toxicology without the use of animals in laboratory experiments. In this work, we extrapolate effects bas…
View article: Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations Open
While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. More…
View article: Using a Bayesian network model to predict effects of pesticides on aquatic community endpoints in a rice field – A southern European case study
Using a Bayesian network model to predict effects of pesticides on aquatic community endpoints in a rice field – A southern European case study Open
In recent years, Bayesian network (BN) models have become more popular as a tool to support probabilistic environmental risk assessments (ERA). They can better account for and communicate uncertainty compared to the deterministic approache…
View article: Probabilistic risk assessment of pesticides under future agricultural and climate scenarios using a bayesian network
Probabilistic risk assessment of pesticides under future agricultural and climate scenarios using a bayesian network Open
The use of Bayesian networks (BN) for environmental risk assessment has increased in recent years as they offer a more transparent way to characterize risk and evaluate uncertainty than the traditional risk assessment paradigms. In this st…
View article: Pharmaceutical pollution: Prediction of environmental concentrations from national wholesales data
Pharmaceutical pollution: Prediction of environmental concentrations from national wholesales data Open
The regulation and monitoring of pharmaceutical pollution in Europe lag behind that of more prominent groups. However, the repurposing of sales data to predict surface water environmental concentrations is a promising supplement to more co…
View article: Radiation adverse outcome pathways (AOPs) are on the horizon: advancing radiation protection through an international Horizon-Style exercise
Radiation adverse outcome pathways (AOPs) are on the horizon: advancing radiation protection through an international Horizon-Style exercise Open
The Adverse Outcome Pathway (AOP) framework, a systematic tool that can link available mechanistic data with phenotypic outcomes of relevance to regulatory decision-making, is being explored in areas related to radiation risk assessment. T…
View article: Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network
Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network Open
Expert consultation led to the identification of key biological events and description of causal linkages between ionizing radiation, reproductive impairment and reduction in population fitness. The study characterized the knowledge domain…
View article: Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning
Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning Open
The expert consultation led to the identification of crucial biological events for the progression of microcephaly upon exposure to IR, and highlighted current knowledge gaps. The machine learning approach was successfully used to screen t…
View article: Ultraviolet B modulates gamma radiation-induced stress responses in Lemna minor at multiple levels of biological organisation
Ultraviolet B modulates gamma radiation-induced stress responses in Lemna minor at multiple levels of biological organisation Open
Elevated levels of ionizing and non-ionizing radiation may co-occur and pose cumulative hazards to biota. However, the combined effects and underlying toxicity mechanisms of different types of radiation in aquatic plants remain poorly unde…
View article: Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events
Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events Open
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-che…
View article: The ecotoxicology of marine tributyltin (TBT) hotspots: A review
The ecotoxicology of marine tributyltin (TBT) hotspots: A review Open
Tributyltin (TBT) was widely used as a highly efficient biocide in antifouling paints for ship and boat hulls. Eventually, TBT containing paints became globally banned when TBT was found to cause widespread contamination and non-target adv…
View article: The MicroClimate Screen – A microscale climate exposure system for assessing the effect of CO2, temperature and UV on marine microalgae
The MicroClimate Screen – A microscale climate exposure system for assessing the effect of CO2, temperature and UV on marine microalgae Open
View article: Probabilistic risk assessment of pesticides under future agricultural and climate scenarios using a Bayesian network
Probabilistic risk assessment of pesticides under future agricultural and climate scenarios using a Bayesian network Open
The use of Bayesian networks (BN) for environmental risk assessment has increased in recent years. One reason is that they offer a more transparent way to characterize risk and evaluate uncertainty than the traditional risk assessment para…
View article: Pharmaceutical pollution: Prediction of environmental concentrations from national wholesales data
Pharmaceutical pollution: Prediction of environmental concentrations from national wholesales data Open
The regulation and monitoring of pharmaceutical pollution in Europe lag behind that of more prominent groups. However, the repurposing of sales data to predict surface water environmental concentrations is a promising supplement to more co…
View article: Prediction of adverse biological effects of chemicals using knowledge graph embeddings
Prediction of adverse biological effects of chemicals using knowledge graph embeddings Open
We have created a knowledge graph based on major data sources used in ecotoxicological risk assessment. We have applied this knowledge graph to an important task in risk assessment, namely chemical effect prediction. We have evaluated nine…
View article: Ultraviolet B Modulates Gamma Radiation-Induced Stress Responses in Lemna Minor at Multiple Levels of Biological Organisation
Ultraviolet B Modulates Gamma Radiation-Induced Stress Responses in Lemna Minor at Multiple Levels of Biological Organisation Open
View article: Toxicity Pathways of Uvb Radiation-Induced Effects on the Marine Copepod Tisbe Battagliai
Toxicity Pathways of Uvb Radiation-Induced Effects on the Marine Copepod Tisbe Battagliai Open