Knut Hestad
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View article: A mixed-method scoping review examining parental perspectives on heavy metal exposure in children
A mixed-method scoping review examining parental perspectives on heavy metal exposure in children Open
Parents' experiences with children exposed to lead vary by area and remain inadequately understood, particularly in low-income countries. There is an increased need for parental knowledge and active prevention measures regarding heavy meta…
View article: The validity of the Meaning in Life in Persons with Dementia Questionnaire (MIND)
The validity of the Meaning in Life in Persons with Dementia Questionnaire (MIND) Open
Background Meaning in life is considered an underestimated asset for people’s well-being, particularly among individuals with dementia residing in nursing homes. However, knowledge on meaning in life in this target group is scarce, among o…
View article: Meaning in life for residents with dementia living in long-term nursing homes: An exploratory qualitative interview-based study
Meaning in life for residents with dementia living in long-term nursing homes: An exploratory qualitative interview-based study Open
Meaning in life is a key aspect of our well-being and is a central issue within the field of existential health. Knowledge is scarce on the experience of meaning in life of people living with dementia. Dementia is defined as loss of memory…
View article: Personalised Prevention of Falls in Persons with Dementia—A Registry-Based Study
Personalised Prevention of Falls in Persons with Dementia—A Registry-Based Study Open
Background/Objectives: Multifactorial prevention of falls in persons with dementia has minimal or non-significant effects. Personalised prevention is recommended. We have previously shown that gait speed, basic activities of daily living (…
View article: Predictors of Fall-Related Injuries in Fallers—A Study in Persons with Cognitive Impairment
Predictors of Fall-Related Injuries in Fallers—A Study in Persons with Cognitive Impairment Open
Background/Objectives: Old age and cognitive impairment/dementia are risk factors for falling and fall-related injuries. We have, in a previous study in persons with cognitive impairment, shown that falls were associated with frailty, redu…
View article: Assessment Teams Experience of Barriers and Challenges When Assessing Loneliness and Depression Among Home‐Dwelling Elderly: A Qualitative Study
Assessment Teams Experience of Barriers and Challenges When Assessing Loneliness and Depression Among Home‐Dwelling Elderly: A Qualitative Study Open
Background Loneliness and depression in the elderly population are a worldwide challenge. Elderly people receiving home care are very vulnerable, as they often suffer from comorbidity and various other challenges. Aim The study aim was to …
View article: Nurses’ perspectives on clinical competence to identify loneliness and depression in older people in home care: a qualitative study
Nurses’ perspectives on clinical competence to identify loneliness and depression in older people in home care: a qualitative study Open
View article: Falls in Persons with Cognitive Impairment—Incidence and Characteristics of the Fallers
Falls in Persons with Cognitive Impairment—Incidence and Characteristics of the Fallers Open
Background/Objectives: The annual incidence of falls is high in older adults with impaired cognitive function and dementia, and injuries have a detrimental effect on disability-adjusted life-years and public health spending. In this regist…
View article: Neuropsychological Characteristics and Quantitative Electroencephalography in Skogholt’s Disease—A Rare Neurodegenerative Disease in a Norwegian Family
Neuropsychological Characteristics and Quantitative Electroencephalography in Skogholt’s Disease—A Rare Neurodegenerative Disease in a Norwegian Family Open
Members of three generations of a Norwegian family (N = 9) with a rare demyelinating disease were studied. Neuropsychological testing was performed using the Mini Mental Status Examination (MMSE), Wechsler Intelligence Scale-III (WAIS-III)…
View article: Individualized goals expressed by patients undergoing stroke rehabilitation: an observational study
Individualized goals expressed by patients undergoing stroke rehabilitation: an observational study Open
Objectives: To explore the rehabilitation goals measured with the Patient-Specific Functional Scale (PSFS) in patients undergoing acute and subacute stroke rehabilitation. In addition, to assess whether PSFS goals corresponded to impairmen…
View article: Cognitive Improvement After Stroke: Prevalence and Trend During the First Three Months
Cognitive Improvement After Stroke: Prevalence and Trend During the First Three Months Open
Introduction: With similar estimates at 3 and 12 months after stroke, 4 out of 10 individuals have cognitive impairment that does not match the criteria for dementia. Cognitive impairment contributes significantly to disability in these pa…
View article: 2 Predictors of Memory Deficits in Patients with Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer’s Disease - Do Disease Severity Moderate the Association?
2 Predictors of Memory Deficits in Patients with Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer’s Disease - Do Disease Severity Moderate the Association? Open
Objective: Age, sex, education, memory, and the APOE e4 allele are related to Alzheimer’s disease (AD) risk. Recently it was suggested that low body mass index (BMI) contributes to the development of AD. The objective of this study was to …
View article: APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway
APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway Open
Background: APOE polymorphism and the Kynurenine pathway (KP) are associated with many disorders, but little is known about associations between APOE polymorphism and the KP. This study explored the associations between the KP and APOE pol…
View article: The Kynurenine Pathway in Healthy Subjects and Subjects with Obesity, Depression and Chronic Obstructive Pulmonary Disease
The Kynurenine Pathway in Healthy Subjects and Subjects with Obesity, Depression and Chronic Obstructive Pulmonary Disease Open
Background: Changes in tryptophan metabolism through the kynurenine pathway (KP) are observed in several disorders and coupled with pathophysiological deviations. Methods: This study retrospectively compared the KP in serum in healthy subj…
View article: Measurement Properties of the Patient-Specific Functional Scale in Rehabilitation for Patients With Stroke: A Prospective Observational Study
Measurement Properties of the Patient-Specific Functional Scale in Rehabilitation for Patients With Stroke: A Prospective Observational Study Open
Objective This study investigated the validity, reliability, responsiveness, and interpretability of the Patient-Specific Functional Scale (PSFS) in subacute stroke rehabilitation to determine its suitability to measure patient-identified …
View article: Effect of coinfections on neurocognitive functioning among people with clade C HIV infection in Zambia
Effect of coinfections on neurocognitive functioning among people with clade C HIV infection in Zambia Open
View article: Reply to Paredes et al. Comment on “Aaseth et al. Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy. Nutrients 2022, 14, 2381”
Reply to Paredes et al. Comment on “Aaseth et al. Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy. Nutrients 2022, 14, 2381” Open
Hereby, we thank Silvia Paredes et al. [...]
View article: Editorial: The heart-brain connection in emotions, cognition, and dementia
Editorial: The heart-brain connection in emotions, cognition, and dementia Open
EDITORIAL article Front. Aging Neurosci., 24 November 2022Sec. Neurocognitive Aging and Behavior https://doi.org/10.3389/fnagi.2022.1074280
View article: Blood pressure trajectories over 35 years and dementia risk: A retrospective study: The HUNT study
Blood pressure trajectories over 35 years and dementia risk: A retrospective study: The HUNT study Open
High blood pressure is a well-established risk factor of dementia. However, the timing of the risk remains controversial. The aim of the present study was to compare trajectories of systolic blood pressure (SBP) over a 35-year follow-up pe…
View article: The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases Open
Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of …
View article: Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy
Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy Open
The efficacy of various bariatric procedures on the mitigation of the obese dyslipidemia remains debated, and the impact of these measures on lipoprotein(a) (Lp(a)) levels is unknown. In this study we aimed to compare the two most commonly…
View article: The Peripheral Kynurenine Pathway and Psychosomatic Comorbidity in Subjects with Morbid Obesity Undergoing Bariatric Surgery
The Peripheral Kynurenine Pathway and Psychosomatic Comorbidity in Subjects with Morbid Obesity Undergoing Bariatric Surgery Open
Background: The Kynurenine pathway (KP) is involved in various disorders, but little is known about the KP and psychosomatic complaints. The aim was to study the peripheral KP and psychosomatic comorbidity in subjects with morbid obesity. …
View article: APOE Polymorphism and Endocrine Functions in Subjects with Morbid Obesity Undergoing Bariatric Surgery
APOE Polymorphism and Endocrine Functions in Subjects with Morbid Obesity Undergoing Bariatric Surgery Open
Background: Obesity is an interplay between genes and the environment, including lifestyle. The genetics of obesity is insufficiently understood. Apolipoprotein E (APOE) genetic polymorphism has been associated with a wide range of disorde…
View article: Relationships of Sources of Meaning and Resilience With Meaningfulness and Satisfaction With Life: A Population-Based Study of Norwegians in Late Adulthood
Relationships of Sources of Meaning and Resilience With Meaningfulness and Satisfaction With Life: A Population-Based Study of Norwegians in Late Adulthood Open
Health-promoting initiatives incorporating meaning-making to enhance the well-being of people in late adulthood are important, particularly as the number of older people is increasing. Resilience and sources of meaning may be related to in…
View article: Trust in crisis
Trust in crisis Open
Crises are associated with a search for meaning and security. In recent years, they have also been associated with increased attention to conspiracy theories. Such theories about COVID-19 have been many. We have looked at several COVID-spe…
View article: Blood Pressure and T-Tau in Spinal Fluid Are Associated With Delayed Recall in Participants With Memory Complaints and Dementia of the Alzheimer’s Type
Blood Pressure and T-Tau in Spinal Fluid Are Associated With Delayed Recall in Participants With Memory Complaints and Dementia of the Alzheimer’s Type Open
Objective : The aim of the study was to determine if systolic blood pressure (SBP), total-tau (t-tau), and beta-amyloid (Aβ) in the cerebral spinal fluid (CSF) were associated with the results on the Consortium to Establish a Registry for …
View article: Cognition in Patients With Memory Difficulties and Dementia Relative to APOE e4 Status
Cognition in Patients With Memory Difficulties and Dementia Relative to APOE e4 Status Open
The aim of this study was to investigate whether cognitive performance was equally influenced by Apolipoprotein E (APOE, with its three alleles, e2, e3, and e4) in patients with subjective cognitive decline (SCD), mild cognitive impairment…
View article: Blood pressure in dementia, mild cognitive impairment, and subjective cognitive decline related to time of death
Blood pressure in dementia, mild cognitive impairment, and subjective cognitive decline related to time of death Open
Objective It is unknown whether systolic blood pressure (SBP) drop is part of the normal aging process or due to the onset of dementia for some people. SBP drop is referring to the decrease in blood pressure often seen before death. Thus, …
View article: Author response for "Blood pressure in dementia, mild cognitive impairment, and subjective cognitive decline related to time of death"
Author response for "Blood pressure in dementia, mild cognitive impairment, and subjective cognitive decline related to time of death" Open
View article: <p>The Applicability of the Patient-Specific Functional Scale (PSFS) in Rehabilitation for Patients with Acquired Brain Injury (ABI) – A Cohort Study</p>
The Applicability of the Patient-Specific Functional Scale (PSFS) in Rehabilitation for Patients with Acquired Brain Injury (ABI) – A Cohort Study Open
In the present study, most patients with ABI (92%) were able to complete the PSFS. Cognitive function on admission was a predictor of improved functioning on the PSFS.