Explanipedia

Glucose Metabolism Controls Oxidative Burst and Lipid Mediator Production in Neutrophils upon Microbial Challenge Open

Andreas Freitag, Kerstin Guenter, Michael Prados, Sophia M. Hochrein, Werner Schmitz , et al. · 2025

SUMMARY Neutrophils are frontline responders against bacterial and fungal pathogens, requiring rapid energy and biosynthetic precursors to mount effective antimicrobial responses. To meet these demands, they primarily rely on aerobic glyco…

Cytokine-mediated inhibition of Staphylococcus aureus adherence and invasion into nonphagocytic cells Open

Arif Luqman, Knut Ohlsen · 2025

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance (Adv. Therap. 5/2025) Open

Sari Rasheed, Florian Umstätter, Eric Mühlberg, Barbro Beijer, Tobias Hertlein , et al. · 2025

Antibiotic–Polycationic Peptide Conjugation as an Effective Strategy to Overcome Daptomycin Resistance Open

Sari Rasheed, Florian Umstätter, Eric Mühlberg, Barbro Beijer, Tobias Hertlein , et al. · 2025

The benefit that antibiotics confer to the welfare of mankind is threatened by bacterial resistance. Resistance to daptomycin, a cyclic lipopeptide frequently used for the treatment of complicated bacteremia, is a prime example of this ala…

Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics Open

Julia Werner, Florian Umstätter, Manuel Ben Böhmann, Katharina Müller, Barbro Beijer , et al. · 2024

Antibiotic‐resistant enterococci represent a significant global health challenge. Unfortunately, most β‐lactam antibiotics are not applicable for enterococcal infections due to intrinsic resistance. To extend their antimicrobial spectrum, …

Adrenergic system: A gateway of reciprocal signaling between host and bacteria Open

Arif Luqman, Knut Ohlsen · 2024

The adrenergic system plays a central role in human physiology. However, it can also affect commensal bacteria via adrenergic hormones. Bacteria use adrenergic hormones as xenosiderophore for iron supply, modulators of biofilm formation, q…

Oral Delivery of the Vancomycin Derivative FU002 by a Surface‐Modified Liposomal Nanocarrier Open

Julia Werner, Florian Umstätter, Tobias Hertlein, Eric Mühlberg, Barbro Beijer , et al. · 2024

Oral delivery of peptide therapeutics faces multiple challenges due to their instability in the gastrointestinal tract and low permeation capability. In this study, the aim is to develop a liposomal nanocarrier formulation to enable the or…

Improved pharmacokinetics and enhanced efficacy of the vancomycin derivative FU002 using a liposomal nanocarrier Open

Julia Werner, Florian Umstätter, Tobias Hertlein, Barbro Beijer, Christian Kleist , et al. · 2023

Antibiotic resistance still represents a global health concern which diminishes the pool of effective antibiotics. With the vancomycin derivative FU002, we recently reported a highly potent substance active against Gram-positive bacteria w…

Searching for new agents against Enterobacteriaceae from nature: approaches, potential plant species, isolated compounds, and their respective properties Open

Nelson E. Masota, Markus Zehe, Gerd Vogg, Knut Ohlsen, Lorenz Meinel , et al. · 2023

Next-generation humanized NSG-SGM3 mice are highly susceptible to Staphylococcus aureus infection Open

Sophia Hung, Amelie Kasperkowitz, Florian Kurz, Liane Dreher, Joachim Diessner , et al. · 2023

Humanized hemato-lymphoid system mice, or humanized mice, emerged in recent years as a promising model to study the course of infection of human-adapted or human-specific pathogens. Though Staphylococcus aureus infects and colonizes a vari…

Novel Effective Fluorinated Benzothiophene-Indole Hybrid Antibacterials against S. aureus and MRSA Strains Open

Marius Seethaler, Tobias Hertlein, Elisa Hopke, Paul Köhling, Knut Ohlsen , et al. · 2022

Increasing antibacterial drug resistance threatens global health, unfortunately, however, efforts to find novel antibacterial agents have been scaled back by the pharmaceutical industry due to concerns about a poor return on investment. Ne…

Isolation and Characterization of Galloylglucoses Effective against Multidrug-Resistant Strains of Escherichia coli and Klebsiella pneumoniae Open

Nelson E. Masota, Knut Ohlsen, Curd Schollmayer, Lorenz Meinel, Ulrike Holzgrabe · 2022

The search for new antibiotics against multidrug-resistant (MDR), Gram-negative bacteria is crucial with respect to filling the antibiotics development pipeline, which is subject to a critical shortage of novel molecules. Screening of natu…

MRSA Infection in the Thigh Muscle Leads to Systemic Disease, Strong Inflammation, and Loss of Human Monocytes in Humanized Mice Open

Sophia Hung, Liane Dreher, Joachim Diessner, Štefan Schwarz, Knut Ohlsen , et al. · 2022

MRSA (Methicillin-resistant Staphylococcus aureus ) is the second-leading cause of deaths by antibiotic-resistant bacteria globally, with more than 100,000 attributable deaths annually. Despite the high urgency to develop a vaccine to cont…

The Old Yellow Enzyme OfrA Fosters Staphylococcus aureus Survival via Affecting Thiol-Dependent Redox Homeostasis Open

Eslam S. Ibrahim, Knut Ohlsen · 2022

Old yellow enzymes (OYEs) are widely found in the bacterial, fungal, and plant kingdoms but absent in humans and have been used as biocatalysts for decades. However, OYEs’ physiological function in bacterial stress response and infection s…

The induction of natural competence adapts staphylococcal metabolism to infection Open

Mar Trallero Cordero, Julia García‐Fernández, Ivan C. Acosta, Ana Yepes, José Avendaño‐Ortiz , et al. · 2022

Impact of Linker Modification and PEGylation of Vancomycin Conjugates on Structure-Activity Relationships and Pharmacokinetics Open

Florian Umstätter, Julia Werner, Leah Zerlin, Eric Mühlberg, Christian Kleist , et al. · 2022

As multidrug-resistant bacteria represent a concerning burden, experts insist on the need for a dramatic rethinking on antibiotic use and development in order to avoid a post-antibiotic era. New and rapidly developable strategies for antim…

Novel Small-Molecule Hybrid-Antibacterial Agents against S. aureus and MRSA Strains Open

Robin Gehrmann, Tobias Hertlein, Elisa Hopke, Knut Ohlsen, Michael Lalk , et al. · 2021

Ongoing resistance developments against antibiotics that also affect last-resort antibiotics require novel antibacterial compounds. Strategies to discover such novel structures have been dimerization or hybridization of known antibacterial…

Staphylococcus aureus Transcriptome Data and Metabolic Modelling Investigate the Interplay of Ser/Thr Kinase PknB, Its Phosphatase Stp, the glmR/yvcK Regulon and the cdaA Operon for Metabolic Adaptation Open

Chunguang Liang, Ana B. Rios‐Miguel, Marcel Jarick, Priya Neurgaonkar, Myriam Girard , et al. · 2021

Serine/threonine kinase PknB and its corresponding phosphatase Stp are important regulators of many cell functions in the pathogen S. aureus. Genome-scale gene expression data of S. aureus strain NewHG (sigB+) elucidated their effect on ph…

Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells Open

Kathrin Stelzner, Aziza Boyny, Tobias Hertlein, Aneta Sroka, Adriana Moldovan , et al. · 2021

Staphylococcus aureus is a major human pathogen, which can invade and survive in non-professional and professional phagocytes. Uptake by host cells is thought to contribute to pathogenicity and persistence of the bacterium. Upon internaliz…

Reproducibility challenges in the search for antibacterial compounds from nature Open

Nelson E. Masota, Gerd Vogg, Knut Ohlsen, Ulrike Holzgrabe · 2021

Background Reproducibility of reported antibacterial activities of plant extracts has long remained questionable. Although plant-related factors should be well considered in serious pharmacognostic research, they are often not addressed in…

Antifungal Potential of Marine Natural Products Open

Ebaa M. El‐Hossary, Cheng Cheng, Mostafa M. Hamed, Ashraf Hamed, Knut Ohlsen , et al. · 2021

Fungal diseases represent an increasing threat to human health worldwide which in some cases might be associated with substantial morbidity and mortality. However, only few antifungal drugs are currently available for the treatment of life…

Overcoming the Mucosal Barrier: Tetraether Lipid‐Stabilized Liposomal Nanocarriers Decorated with Cell‐Penetrating Peptides Enable Oral Delivery of Vancomycin Open

Philipp Uhl, Max Sauter, Tobias Hertlein, Dominik Witzigmann, Flavia Laffleur , et al. · 2021

Despite the high medical need for oral peptide delivery, instability in the gastrointestinal tract and low mucosal permeation still impede this preferred route of administration. Herein, a liposomal nanocarrier combining two self‐reliant s…

Corrigendum: Vancomycin Resistance is Overcome by Conjugation of Polycationic Peptides Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

A vancomycin-arginine conjugate that is effective against Gram-negative bacteria, [1] and a D-octaarginine conjugate of vancomycin that eliminates biofilm-associated MRSA in a murine wound infection model, MRSA persister cells, and vancomy…

Berichtigung: Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

Vancomycin-Lipopeptide Conjugates with High Antimicrobial Activity on Vancomycin-Resistant Enterococci Open

Eric Mühlberg, Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen , et al. · 2020

Multidrug-resistant bacteria represent one of the most important health care problems worldwide. While there are numerous drugs available for standard therapy, there are only a few compounds capable of serving as a last resort for severe i…

Graphisches Inhaltsverzeichnis: Angew. Chem. 23/2020 Open

Lena Scherthan, Alan Powell, Volker Schünemann, Carmen Leitner, Marion Schulz , et al. · 2020

The interpretation of the chemical bond in NaBH 3À as a dative bond Na À !BH 3 proposed by Liu et al. is questioned.The dissociation products are Na À and BH 3 but the nature of the bond changes during the bond formation from dative intera…

Inside Back Cover: Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides (Angew. Chem. Int. Ed. 23/2020) Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

Bacterial resistance threatens to destroy the achievements of antibiotic therapy. As P. Uhl and co-workers report in their Communication on page 8823, a 1000-fold increase in the activity of the reserve antibiotic vancomycin was achieved b…

Überwindung von Vancomycinresistenzen durch Modifikation mit polykationischen Peptiden Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

Die zunehmende Prävalenz von Resistenzen bei Bakterien gegen Glykopeptid‐Antibiotika macht auch vor Vancomycin nicht halt. Um die ursprünglich hohe Effektivität gegen diese resistenten Bakterien wieder zu erzielen, wurden hier polykationis…

Vancomycin Resistance Is Overcome by Conjugation of Polycationic Peptides Open

Florian Umstätter, Cornelius Domhan, Tobias Hertlein, Knut Ohlsen, Eric Mühlberg , et al. · 2020

Multidrug‐resistant bacteria represent one of the biggest challenges facing modern medicine. The increasing prevalence of glycopeptide resistance compromises the efficacy of vancomycin, for a long time considered as the last resort for the…

Intracellular<i>Staphylococcus aureus</i>employs the cysteine protease staphopain A to induce host cell death in epithelial cells Open

Kathrin Stelzner, Tobias Hertlein, Aneta Sroka, Adriana Moldovan, Kerstin Paprotka , et al. · 2020

Staphylococcus aureus is a major human pathogen, which can invade and survive in non-professional and professional phagocytes. Intracellularity is thought to contribute to pathogenicity and persistence of the bacterium. Upon internalizatio…

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