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Drug treatment alters performance in a neural microphysiological system of information processing Open
Assessment of pharmacological intervention on in vitro neural systems often emphasizes molecular and structural changes. However, neural systems fundamentally process and act on information. For preclinical assays to predict drug efficacy,…
Drug treatment alters performance in a neural microphysiological system of information processing Open
Assessment of pharmacological intervention on in vitro neural systems often emphasizes molecular and structural changes. However, neural systems fundamentally process and act on information. For preclinical assays to predict drug efficacy,…
View article: Circadian clocks in human cerebral organoids
Circadian clocks in human cerebral organoids Open
Summary Circadian rhythms result from cell-intrinsic timing mechanisms that impact health and disease 1,2 . To date, however, neural circadian research has largely focused on the hypothalamic circuitry of nocturnal rodents 3 . Whether circ…
Transcription factor combinations that define human astrocyte identity encode significant variation of maturity and function Open
Increasing evidence indicates that cellular identity can be reduced to the distinct gene regulatory networks controlled by transcription factors (TFs). However, redundancy exists in these states as different combinations of TFs can induce …
Neuronal Interfaces: Interactions of Neurons with Physical Environments (Adv. Healthcare Mater. 15/2017) Open
In Progress Report 1700267, Orit Shefi and co-workers exploit studies of platforms generated with a range of physical topographies, from micro- down to nano- scale, that interact effectively with neurons, affecting differentiation, outgrow…