Koen Baas
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View article: Assessment of neurocognitive functioning in sickle cell disease and thalassaemia and the association with silent cerebral infarcts, cerebral haemodynamics and oxygen metabolism
Assessment of neurocognitive functioning in sickle cell disease and thalassaemia and the association with silent cerebral infarcts, cerebral haemodynamics and oxygen metabolism Open
Summary Neurocognitive impairment is a key concern in sickle cell disease (SCD) patients, affecting several factors including academic performance, employment and quality of life. While the exact causes remain unclear, correlations with si…
View article: Cerebral hemodynamics and oxygen metabolism in patients with milder and severe forms of sickle cell disease and thalassemia
Cerebral hemodynamics and oxygen metabolism in patients with milder and severe forms of sickle cell disease and thalassemia Open
Silent cerebral infarcts (SCIs) are present in patients with sickle cell disease (SCD) and thalassemia, but the pathophysiology of SCIs is not fully understood. Previous studies mainly focused on cerebral hemodynamics and oxygen metabolism…
View article: The effect of mobile phone electromagnetic fields on the human resting state wake EEG and event‐related potential: A systematic review and meta‐analysis
The effect of mobile phone electromagnetic fields on the human resting state wake EEG and event‐related potential: A systematic review and meta‐analysis Open
The rapid growth of mobile phone usage and its use of radiofrequency electromagnetic fields (RF‐EMF) have raised concerns about potential health risks. Researchers have conducted studies to examine the effects of RF‐EMF on the brain using …
View article: Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease
Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease Open
Sickle cell disease (SCD) is complicated by silent cerebral infarcts (SCIs), for which anemia is an important risk factor. Despite normal oxygen delivery (OD), cerebral vascular reserve (CVR), and cerebral metabolic rate of oxygen (CMRO 2 …
View article: Contrast‐free dynamic susceptibility contrast using sinusoidal and bolus oxygenation challenges
Contrast‐free dynamic susceptibility contrast using sinusoidal and bolus oxygenation challenges Open
Deoxygenation‐based dynamic susceptibility contrast (dDSC) MRI uses respiratory challenges as a source of endogenous contrast as an alternative to gadolinium injection. These gas challenges induce T2*‐weighted MRI signal losses, after whic…
View article: Assessment of Neurocognitive Functioning in Sickle Cell Disease and Thalassemia and the Association with Silent Cerebral Infarcts and Cerebral Hemodynamics and Oxygen Metabolism
Assessment of Neurocognitive Functioning in Sickle Cell Disease and Thalassemia and the Association with Silent Cerebral Infarcts and Cerebral Hemodynamics and Oxygen Metabolism Open
Introduction Neurocognitive impairment is a significant problem in patients with sickle cell disease (SCD), affecting various life domains such as academic achievement, career progress, and general life quality. The cause of this impairmen…
View article: Cerebral hemodynamics and oxygenation in adult patients with sickle cell disease after stem cell transplantation
Cerebral hemodynamics and oxygenation in adult patients with sickle cell disease after stem cell transplantation Open
Sickle cell disease (SCD) is characterized by chronic hemolytic anemia associated with impaired cerebral hemodynamics and oxygen metabolism. Hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment for patien…
View article: <scp>ISMRM</scp> Open Science Initiative for Perfusion Imaging (OSIPI): <scp>ASL</scp> pipeline inventory
<span>ISMRM</span> Open Science Initiative for Perfusion Imaging (OSIPI): <span>ASL</span> pipeline inventory Open
Purpose To create an inventory of image processing pipelines of arterial spin labeling (ASL) and list their main features, and to evaluate the capability, flexibility, and ease of use of publicly available pipelines to guide novice ASL use…
View article: Progressive Changes in Cerebral Apparent Diffusion Values in Fabry Disease: A 5-Year Follow-up MRI Study
Progressive Changes in Cerebral Apparent Diffusion Values in Fabry Disease: A 5-Year Follow-up MRI Study Open
Our results indicate that in Fabry disease, changes in diffusion precede the formation of white matter lesions and that microstructural changes progress faster in men compared with women. These findings suggest that DWI may be of predictiv…
View article: S278: CEREBRAL HEMODYNAMICS AND OXYGEN METABOLISM IN PATIENTS WITH MILD AND SEVERE SICKLE CELL DISEASE AND THALASSEMIA
S278: CEREBRAL HEMODYNAMICS AND OXYGEN METABOLISM IN PATIENTS WITH MILD AND SEVERE SICKLE CELL DISEASE AND THALASSEMIA Open
Topic: 26. Sickle cell disease Background: Sickle cell disease (SCD) is complicated by cerebral infarctions. These include silent cerebral infarcts (SCIs) which can be found in 40% of the patients by the age of 20 years and progress furthe…
View article: S279: EFFECT OF VOXELOTOR ON CEREBRAL PERFUSION AND CEREBRAL OXYGEN METABOLISM IN ADULT PATIENTS WITH SICKLE CELL DISEASE; THE COVERAGE STUDY
S279: EFFECT OF VOXELOTOR ON CEREBRAL PERFUSION AND CEREBRAL OXYGEN METABOLISM IN ADULT PATIENTS WITH SICKLE CELL DISEASE; THE COVERAGE STUDY Open
Background: Sickle cell disease (SCD) is characterized by haemolytic anaemia, vaso-occlusive painful crises and widespread organ complications. A severe complication is cerebral ischemia leading to overt strokes or silent cerebral infarcti…
View article: P1421: THE EFFECT OF HEMATOPOIETIC STEM CELL TRANSPLANTATION ON CEREBRAL PERFUSION AND OXYGEN METABOLISM IN PATIENTS WITH SICKLE CELL DISEASE
P1421: THE EFFECT OF HEMATOPOIETIC STEM CELL TRANSPLANTATION ON CEREBRAL PERFUSION AND OXYGEN METABOLISM IN PATIENTS WITH SICKLE CELL DISEASE Open
Topic: 26. Sickle cell disease Background: Sickle cell disease (SCD) is complicated by a high prevalence of silent cerebral infarcts (SCI) which increases with age. Hematopoietic stem cell transplantation (HSCT) is currently the only curat…
View article: Venous Blood Oxygenation Measurements Using <scp>TRUST</scp> and <scp>T2‐TRIR MRI</scp> During Hypoxic and Hypercapnic Gas Challenges
Venous Blood Oxygenation Measurements Using <span>TRUST</span> and <span>T2‐TRIR MRI</span> During Hypoxic and Hypercapnic Gas Challenges Open
Background Oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO 2 ) may serve as biomarkers in several diseases. OEF and CMRO 2 can be estimated from venous blood oxygenation (Y v ) levels, which in turn can be calc…
View article: Sinusoidal CO2 respiratory challenge for concurrent perfusion and cerebrovascular reactivity MRI
Sinusoidal CO2 respiratory challenge for concurrent perfusion and cerebrovascular reactivity MRI Open
Introduction: Deoxygenation-based dynamic susceptibility contrast (dDSC) has previously leveraged respiratory challenges to modulate blood oxygen content as an endogenous source of contrast alternative to gadolinium injection in perfusion-…
View article: Impairment of Cerebrovascular Hemodynamics in Patients With Severe and Milder Forms of Sickle Cell Disease
Impairment of Cerebrovascular Hemodynamics in Patients With Severe and Milder Forms of Sickle Cell Disease Open
In patients with sickle cell disease (SCD), cerebral blood flow (CBF) is elevated to counteract anemia and maintain oxygen supply to the brain. This may exhaust the vasodilating capacity of the vessels, possibly increasing the risk of sile…
View article: Effects of Acquisition Parameter Modifications and Field Strength on the Reproducibility of Brain Perfusion Measurements Using Arterial Spin-Labeling
Effects of Acquisition Parameter Modifications and Field Strength on the Reproducibility of Brain Perfusion Measurements Using Arterial Spin-Labeling Open
Arterial spin-labeling imaging is reproducible at both field strengths, and the reproducibility is not significantly correlated with age. Furthermore, 3T tolerates more acquisition parameter variations and allows more extensive optimizatio…