Koen D. Reesink
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View article: Spectral analysis of bruits with an electronic stethoscope enhances screening of carotid stenosis and plaques beyond conventional auscultation
Spectral analysis of bruits with an electronic stethoscope enhances screening of carotid stenosis and plaques beyond conventional auscultation Open
Our findings demonstrate that the electronic stethoscope with spectral analysis is promising for identifying severe stenosis but has limited sensitivity for detecting any plaque. The performance obtained with this approach is superior to t…
View article: Arterial stiffness is associated with small and large fiber neuropathy: The Maastricht Study
Arterial stiffness is associated with small and large fiber neuropathy: The Maastricht Study Open
Aim: To examine the association between arterial stiffness as determined by carotid–femoral pulse wave velocity (cfPWV) and neuropathy (retinal, corneal, and peripheral). Methods: We used population-based cross-sectional data from The Maas…
View article: Vascular aging impairs active modulation of murine aortic stiffness by smooth muscle cells
Vascular aging impairs active modulation of murine aortic stiffness by smooth muscle cells Open
Using a biaxial pressure myograph that mimics physiological loading conditions, this study demonstrates the capacity of vascular smooth muscle cells in male C57BL/6J mice at 5 mo of age to modulate aortic stiffness through vasoconstriction…
View article: Impact of Dynamic Axial Stretching on the Arterial Pulse Wave Velocity: Physical Foundation and Clinical Implications
Impact of Dynamic Axial Stretching on the Arterial Pulse Wave Velocity: Physical Foundation and Clinical Implications Open
Introduction: The conventional derivation of pressure pulse wave velocity (PWV) relies on the wave equation for blood flow in a uniform elastic artery, wherein PWV is considered dependent on the linear elasticity of the artery and on the b…
View article: Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice
Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice Open
In an animal model of T1D, GLO1 overexpression attenuates arterial stiffening at the underlying material levels, by modifying collagen ultrastructure and viscoelastic properties. Targeting MGO may provide a novel approach to prevent arteri…
View article: Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants
Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants Open
Histomorphometric differences in cell‐matrix properties were analysed between ascending thoracic aortic aneurysm (ATAA), dissection (ATAAD) and non‐aneurysmal patients, as well as across the circumference of the aneurysms in ATAA cases. Fr…
View article: Plasma Reactive Dicarbonyls Are Not Independently Associated With Arterial Stiffness: The Maastricht Study
Plasma Reactive Dicarbonyls Are Not Independently Associated With Arterial Stiffness: The Maastricht Study Open
BACKGROUND Arterial stiffness is a strong predictor of cardiovascular diseases and all-cause mortality. Increased concentrations of highly reactive dicarbonyl compounds—methylglyoxal (MGO), glyoxal (GO), and/or 3-deoxyglucosone (3-DG)—may …
View article: Beat-to-beat variability of aortic pulse wave velocity: implications for aortic stiffness measurements
Beat-to-beat variability of aortic pulse wave velocity: implications for aortic stiffness measurements Open
Objectives: Aortic pulse wave velocity (aPWV) predicts cardiovascular risk. Being the reference method for aortic stiffness evaluation, invasive aPWV is also recommended for validation of noninvasive devices. Because of intrinsic haemodyna…
View article: The MAASWERP Study: An International, Comparative Case Study on Measuring Biomechanics of the Aged Murine Aorta
The MAASWERP Study: An International, Comparative Case Study on Measuring Biomechanics of the Aged Murine Aorta Open
Introduction: Arterial stiffening is a hallmark of vascular ageing, and unravelling its underlying mechanisms has become a central theme in the field of cardiovascular disease. While various techniques and experimental setups are accessibl…
View article: Association of Objectively Measured Sedentary Behavior With Arterial Stiffness: Findings From the Nijmegen Exercise Study
Association of Objectively Measured Sedentary Behavior With Arterial Stiffness: Findings From the Nijmegen Exercise Study Open
Sedentary behavior (SB) may affect arterial stiffness, preceding the development of cardiovascular disease. We investigated the association of objectively measured SB with arterial stiffness. We also investigated factors that affected this…
View article: The MAASWERP study: An international, comparative case study on measuring biomechanics of the aged murine aorta
The MAASWERP study: An international, comparative case study on measuring biomechanics of the aged murine aorta Open
Arterial stiffening is a hallmark of vascular ageing, and unravelling its underlying mechanisms has become a central theme in the field of cardiovascular disease. While various techniques and experimental setups are accessible for investig…
View article: Measurements and System Identification for the Characterization of Smooth Muscle Cell Dynamics
Measurements and System Identification for the Characterization of Smooth Muscle Cell Dynamics Open
Biological tissue integrity is actively maintained by cells. It is essential to comprehend how cells accomplish this in order to stage tissue diseases. However, addressing the complexity of a cell's system of interrelated mechanisms poses …
View article: Effect of rapid cooling, frozen storage, and thawing on the passive viscoelastic properties and structure of the rat aorta
Effect of rapid cooling, frozen storage, and thawing on the passive viscoelastic properties and structure of the rat aorta Open
Biological tissues decay over time after harvesting, which alters their biomechanical properties. This poses logistical challenges for studies investigating passive arterial biomechanics as tissues need to be characterized shortly after ex…
View article: Wall-to-Lumen Ratio Estimation from Excised Ascending Aortic Aneurysm Rings
Wall-to-Lumen Ratio Estimation from Excised Ascending Aortic Aneurysm Rings Open
Mechanical equilibrium and homeostasis of the vessel wall are dependent on its wall-to-lumen ratio. Ex vivo studies performing wall thickness measurements do not perform measurements on intact rings. Therefore, they lack ex vivo lumen radi…
View article: Evaluating flash freezing for preservation of rat abdominal aorta for delayed biomechanical characterization
Evaluating flash freezing for preservation of rat abdominal aorta for delayed biomechanical characterization Open
Most studies investigating arterial stiffening use animal rather than human arteries. This is because human tissue becomes available in small amounts and at irregular times, which complicates planning of experimental work. Suitable tissue …
View article: Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians
Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians Open
Background Ethnicity impacts cardiovascular disease (CVD) risk, and South Asians demonstrate a higher risk than White Europeans. Arterial stiffness is known to contribute to CVD, and differences in arterial stiffness between ethnicities co…
View article: Evidence in Clinical Studies for the Role of Wall Thickness in Ascending Thoracic Aortic Aneurysms: A Scoping Review
Evidence in Clinical Studies for the Role of Wall Thickness in Ascending Thoracic Aortic Aneurysms: A Scoping Review Open
Background: Ascending thoracic aortic aneurysm is a chronic degenerative pathology characterized by dilatation of this segment of the aorta. Clinical guidelines use aortic diameter and growth rate as predictors of rupture and dissection. H…
View article: The Maastricht Acquisition Platform for Studying Mechanisms of Cell–Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease
The Maastricht Acquisition Platform for Studying Mechanisms of Cell–Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease Open
Current management guidelines for ascending thoracic aortic aneurysms (aTAA) recommend intervention once ascending or sinus diameter reaches 5–5.5 cm or shows a growth rate of >0.5 cm/year estimated from echo/CT/MRI. However, many aTAA dis…
View article: Biomechanical Characterisation of Thoracic Ascending Aorta with Preserved Pre-Stresses
Biomechanical Characterisation of Thoracic Ascending Aorta with Preserved Pre-Stresses Open
Mechanical properties of an aneurysmatic thoracic aorta are potential markers of future growth and remodelling and can help to estimate the risk of rupture. Aortic geometries obtained from routine medical imaging do not display wall stress…
View article: The Ultrasound Window Into Vascular Ageing: A Technology Review by the <scp>VascAgeNet COST</scp> Action
The Ultrasound Window Into Vascular Ageing: A Technology Review by the <span>VascAgeNet COST</span> Action Open
Non‐invasive ultrasound (US) imaging enables the assessment of the properties of superficial blood vessels. Various modes can be used for vascular characteristics analysis, ranging from radiofrequency (RF) data, Doppler‐ and standard B/M‐m…