Koen Van Hoeck
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View article: A Targeted Release Capsule of Lanthanum Carbonate: a New Efficient Cheap Treatment for Primary Hyperoxalurias
A Targeted Release Capsule of Lanthanum Carbonate: a New Efficient Cheap Treatment for Primary Hyperoxalurias Open
trcLanth.Carb. is a promising repurposed, efficient, nontoxic, and cheap drug, lacking serious side effects in the treatment of any type of PH in whatever place in the world. A randomized controlled trial supporting this proof-of-concept i…
View article: Assessment of Within- and Inter-Patient Variability of Uremic Toxin Concentrations in Children with CKD
Assessment of Within- and Inter-Patient Variability of Uremic Toxin Concentrations in Children with CKD Open
To promote improved trial design in upcoming randomized clinical trials in childhood chronic kidney disease (CKD), insight in the within- and inter-patient variability of uremic toxins with its nutritional, treatment- and patient-related c…
View article: Mental health and professional outcomes in parents of children with chronic kidney disease
Mental health and professional outcomes in parents of children with chronic kidney disease Open
Background This study evaluated stress, anxiety and depression symptoms and their associated factors in parents of children with chronic kidney disease (CKD). Methods This cross-sectional study compared parents of CKD patients (0–18 years)…
View article: Assessing fluid shifts in the pediatric surgical patient: is bioimpedance a promising tool
Assessing fluid shifts in the pediatric surgical patient: is bioimpedance a promising tool Open
Background: assessing the fluid status of pediatric surgical patients is still a difficult task Objectives: assessing fluid shifts pre- and postoperatively in pediatric patients undergoing general anesthesia using bioimpedance spectrometry…
View article: Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders
Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders Open
Background The Flemish Collaborative Glomerulonephritis Group (FCGG) registry provides complete population data on kidney disease epidemiology in the region of Flanders (Belgium), as it captures all native kidney biopsies performed in its …
View article: Epidemiology of native kidney disease in Flanders: results from the FCGG kidney biopsy registry
Epidemiology of native kidney disease in Flanders: results from the FCGG kidney biopsy registry Open
Background The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is the first population-based native kidney biopsy registry in Flanders, Belgium. In this first analysis, we report on patient demographics, frequency distributi…
View article: Dietary Fibre Intake Is Associated with Serum Levels of Uraemic Toxins in Children with Chronic Kidney Disease
Dietary Fibre Intake Is Associated with Serum Levels of Uraemic Toxins in Children with Chronic Kidney Disease Open
Imbalanced colonic microbial metabolism plays a pivotal role in generating protein-bound uraemic toxins (PBUTs), which accumulate with deteriorating kidney function and contribute to the uraemic burden of children with chronic kidney disea…
View article: Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population
Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population Open
Protein-bound uremic toxins (PBUTs) play a role in the multisystem disease that children on hemodialysis (HD) are facing, but little is known about their levels and protein binding (%PB). In this study, we evaluated the levels and %PB of s…
View article: Haemolytic uremic syndrome surveillance in children less than 15 years in Belgium, 2009–2015
Haemolytic uremic syndrome surveillance in children less than 15 years in Belgium, 2009–2015 Open
The incidence of paediatric HUS in Belgium is high compared to other European countries. Its surveillance in Belgium is quite comprehensive and, although less effective than monitoring all STEC infections to detect the emergence of outbrea…
View article: Longitudinal Study of the Role of Epidermal Growth Factor on the Fractional Excretion of Magnesium in Children: Effect of Calcineurin Inhibitors
Longitudinal Study of the Role of Epidermal Growth Factor on the Fractional Excretion of Magnesium in Children: Effect of Calcineurin Inhibitors Open
Background: It was shown in animal models and adults that the epidermal growth factor (EGF) is involved in the pathophysiology of calcineurin inhibitor (CNI) induced renal magnesium loss. In children, however, the exact mechanism remains u…
View article: Belgian consensus statement on the diagnosis and management of patients with atypical hemolytic uremic syndrome
Belgian consensus statement on the diagnosis and management of patients with atypical hemolytic uremic syndrome Open
peer reviewed
View article: Concentrations of representative uraemic toxins in a healthy versus non-dialysis chronic kidney disease paediatric population
Concentrations of representative uraemic toxins in a healthy versus non-dialysis chronic kidney disease paediatric population Open
This is the first study to establish reference values for a wide range of uraemic toxins in non-dialysis CKD and healthy children. We observed an accumulation of multiple uraemic toxins, each with a particular retention profile according t…
View article: Risk factors for loss of residual renal function in children treated with chronic peritoneal dialysis
Risk factors for loss of residual renal function in children treated with chronic peritoneal dialysis Open
In dialyzed patients, preservation of residual renal function is associated with better survival, lower morbidity, and greater quality of life. To analyze the evolution of residual diuresis over time, we prospectively monitored urine outpu…