Explanipedia

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits Open

Andrew Brown, Juan Fernández‐Tajes, Mun‐Gwan Hong, Caroline Brorsson, Robert W. Koivula , et al. · 2023

Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials Open

Adem Y. Dawed, Andrea Mari, Andrew Brown, Timothy J. McDonald, Lin Li , et al. · 2022

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study Open

Andrea Tura, Eleonora Grespan, Christian Göbl, Robert W. Koivula, Paul W. Franks , et al. · 2021

Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 mo…

A reference map of potential determinants for the human serum metabolome Open

Noam Bar, Tal Korem, Omer Weissbrod, David Zeevi, Daphna Rothschild , et al. · 2020

ManifoldOptim: An R Interface to the ROPTLIB Library for Riemannian Manifold Optimization Open

Seán Martin, Andrew M. Raim, Wen Huang, Kofi P. Adragni · 2020

Manifold optimization appears in a wide variety of computational problems in the applied sciences. In recent statistical methodologies such as sufficient dimension reduction and regression envelopes, estimation relies on the optimization o…

ManifoldOptim: An R Interface to the ROPTLIB Library for Riemannian Manifold Optimization Open

Seán Martin, Andrew M. Raim, Wen Huang, Kofi P. Adragni · 2020

Manifold optimization appears in a wide variety of computational problems in the applied sciences. In recent statistical methodologies such as sufficient dimension reduction and regression envelopes, estimation relies on the optimization o…

Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4 ) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1 ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study Open

Adem Y. Dawed, Kaixin Zhou, Nienke van Leeuwen, Anubha Mahajan, Neil Robertson , et al. · 2019

OBJECTIVE Gastrointestinal adverse effects occur in 20–30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5–10% of the cases. Gastrointestinal intolerance may reflect localized high concentratio…

Using Historical Data for Retrospective Prediction of Rainfall In the Midwest Open

Ephraim Alfa, Huiyi Chen, Kristen J. Hansen, Mathew Prindle, Sai K. Popuri , et al. · 2018

The Missouri River Basin (MRB) is an important food-producing region in the United States and Canada. Climate variability and water availability affect crops production in this region. Past climate data have been recorded at various locati…

Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3Receptor Agonist Open

James A. Monn, Steven S. Henry, Steven M. Massey, David K. Clawson, Qi Chen , et al. · 2018

Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu₃) receptors, but small molecule tools are lacking. As part of our ongoing efforts to identify…

CCDC 1576904: Experimental Crystal Structure Determination Open

James A. Monn, Steven S. Henry, Steven M. Massey, David K. Clawson, Qi Chen , et al. · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Minimum average deviance estimation for sufficient dimension reduction Open

Kofi P. Adragni · 2017

Sufficient dimension reduction reduces the dimensionality of data while preserving relevant regression information. In this article, we develop Minimum Average Deviance Estimation (MADE) methodology for sufficient dimension reduction. It e…

Minimum Average Deviance Estimation for Sufficient Dimension Reduction Open

Kofi P. Adragni, Andrew M. Raim, Elias Al-Najjar · 2016

Sufficient dimension reduction reduces the dimensionality of data while preserving relevant regression information. In this article, we develop Minimum Average Deviance Estimation (MADE) methodology for sufficient dimension reduction. It e…

Spatio-temporal analysis of precipitation data via a sufficient dimension reduction in parallel Open

Sai K. Popuri, Ross Flieger Allison, Lois L. Miller, Danielle Sykes, Pablo Valle , et al. · 2016

Prediction of precipitation using simulations on various climate variables provided by Global Climate Models (GCM) as covariates is often required for regional hydrological assessment studies. In this paper, we use a sufficient dimension r…

Statistical Analysis of a Case-Control Alzheimer's Disease: A Retropective Approach with Su cient Dimension Reduction Open

Trevor V. Adriaanse, Meshach Hopkins, Rebecca Rachan, Subodh Selukar, Elias Al Najjar , et al. · 2015

Alzheimer's Disease is a neurological disorder chiefly present in the elderly that affects functions of the brain such as memory and logic, eventually resulting in death. There is no known cure to Alzheimer's and evidence points to the pos…

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