Kohei Kasahara
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View article: A deep learning method for event recognition in CALET data
A deep learning method for event recognition in CALET data Open
View article: <scp>CML</scp> With Mutant <scp>ASXL1</scp> Showed Decreased Sensitivity to <scp>TKI</scp> Treatment via Upregulation of the <scp>ALOX5</scp>‐<scp>BLTR</scp> Signaling Pathway
<span>CML</span> With Mutant <span>ASXL1</span> Showed Decreased Sensitivity to <span>TKI</span> Treatment via Upregulation of the <span>ALOX5</span>‐<span>BLTR</span> Signaling Pathway Open
In this study, the mechanisms of tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML) were investigated focusing additional sex combs ‐ like 1 ( ASXL1 ) gene mutations and their downstream effects. While TKIs have i…
View article: Immune Checkpoint Inhibitor-Related Aortitis Treated with Nivolumab for Esophageal Squamous Cell Carcinoma
Immune Checkpoint Inhibitor-Related Aortitis Treated with Nivolumab for Esophageal Squamous Cell Carcinoma Open
ICI-related aortitis should be considered as a differential diagnosis for unexplained fever after ICI administration.
View article: Impact of histologically poorly cohesive phenotype as a prognostic factor in patients with pStage II/III gastric cancer undergoing adjuvant chemotherapy
Impact of histologically poorly cohesive phenotype as a prognostic factor in patients with pStage II/III gastric cancer undergoing adjuvant chemotherapy Open
Purpose We evaluated the impact of histological type to evaluate prognostic factors after adjuvant chemotherapy (AC) in patients with pStage II and III gastric cancer. Methods Overall, 384 patients with pStage II and III gastric cancer und…
View article: Duodenal Pyloric Gland Adenoma (PGA) with Invagination into the Jejunum—A Case Report—
Duodenal Pyloric Gland Adenoma (PGA) with Invagination into the Jejunum—A Case Report— Open
症例は71歳,男性.2年前より下血を自覚していた.嘔気のため受診し,血液検査にて貧血を認め,精査加療目的に入院となった.上部消化管内視鏡検査にて幽門周囲から発生し,Treitz靱帯を越えて空腸へ脱出するポリープ様の腫瘍を認め,十二指腸腫瘍のinvaginationと診断し手術を施行した.開腹し,Treitz靱帯から20cm肛門側の空腸に腫瘍先進部を確認した.腫瘍径が大きく口側への整復は困難であり,空腸を切開し腫瘍を導出してから茎部で切離した.術中内視鏡にて十二指腸球部に基部…
View article: The preceding hyponatremia is a useful hallmark for the diagnosis of HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation
The preceding hyponatremia is a useful hallmark for the diagnosis of HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation Open
View article: Antiretroviral therapy achieved metabolic complete remission of hepatic AIDS related Epstein-Barr virus-associated smooth muscle tumor
Antiretroviral therapy achieved metabolic complete remission of hepatic AIDS related Epstein-Barr virus-associated smooth muscle tumor Open
Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is a rare mesenchymal tumor which occurs in immunocompromised patients. The immune status is an important factor in the treatment of EBV-SMTs, but the efficacy of antiretroviral t…
View article: A Case of Gastrointestinal Stromal Tumor with a Tumor Embolus in the Portal Vein
A Case of Gastrointestinal Stromal Tumor with a Tumor Embolus in the Portal Vein Open
症例は43歳の男性で，めまいを主訴に近医を受診した．Hb 4.7 g/dlと貧血を認め，上部消化管内視鏡検査で胃体上部に潰瘍出血を伴う粘膜下腫瘤を認めた．組織検査で胃gastrointestinal stromal tumor（以下，GISTと略記）と診断され，加療目的に当科へ紹介された．腹部造影CTで胃壁外に伸展する長径11 cm大の腫瘍と，左胃静脈から脾静脈，門脈本幹に連続する塞栓像を認め，FDG-PET/CTで主病巣にSUVmax 9.9，門脈内にSUVmax 5.6…
View article: Real-World Therapeutic Outcomes of S-1 Adjuvant Chemotherapy for pStage II/III Gastric Cancer in the Elderly
Real-World Therapeutic Outcomes of S-1 Adjuvant Chemotherapy for pStage II/III Gastric Cancer in the Elderly Open
Background: The predictive factors for discontinuation of S-1 administration and prognostic factors in elderly patients with pStage II/III gastric cancer receiving S-1 adjuvant chemotherapy remain unclear. Methods:<…
View article: Nivolumab-induced immune thrombocytopenia in a patient with malignant pleural mesothelioma
Nivolumab-induced immune thrombocytopenia in a patient with malignant pleural mesothelioma Open
Malignant pleural mesothelioma (MPM) is a rare and highly aggressive tumor. Nivolumab showed durable antitumor effect in patients with recurrent MPM and was approved for those patients in Japan in 2018. Immune related adverse event (irAE) …
View article: Systemic Review and Meta-analysis of Impact of Splenectomy for Advanced Gastric Cancer
Systemic Review and Meta-analysis of Impact of Splenectomy for Advanced Gastric Cancer Open
Out of 765 articles, 18 studies (combined n=6,341) were included in the analysis. Four randomized controlled trials (RCT) and eight retrospective studies suggested the benefits of spleen-preserving gastrectomy. Six retrospective studies sh…
View article: Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia: A Hokkaido Leukemia Net Study
Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia: A Hokkaido Leukemia Net Study Open
View article: Effect of <i>Lactobacillus casei</i> strain Shirota-fermented milk on metabolic abnormalities in obese prediabetic Japanese men: a randomised, double-blind, placebo-controlled trial
Effect of <i>Lactobacillus casei</i> strain Shirota-fermented milk on metabolic abnormalities in obese prediabetic Japanese men: a randomised, double-blind, placebo-controlled trial Open
An obesity-related prediabetic state is characterised by metabolic abnormalities such as post-glucose load hyperglycaemia and dyslipidaemia and consequently increases the risk for type 2 diabetes and cardiovascular disease. This study aime…
View article: Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy
Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy Open
We report a case of acute myeloid leukemia (AML) with two cytogenetically unrelated clones. The patient was a 45-year-old male who was diagnosed with acute monoblastic leukemia (AMoL). Initial G-band analysis showed 51,XY,+6,+8,inv(9)(p12q…