Kenichi Yoshimura
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View article: Anatomical study of diaphragmatic crura and segmental vessels for lumbar spinal surgery
Anatomical study of diaphragmatic crura and segmental vessels for lumbar spinal surgery Open
The diaphragmatic crus shows laterality in origin, width, and position, with distinct relationships to segmental vessels. Recognizing these anatomical features may help surgeons minimize vascular injury and improve safety during lumbar spi…
View article: Eppikajutsuto for Treatment of Lymphatic Malformations in Children
Eppikajutsuto for Treatment of Lymphatic Malformations in Children Open
Importance Lymphatic malformations (LMs) are congenital vascular anomalies with limited treatment options. Eppikajutsuto, a traditional Japanese (Kampo) herbal medicine, is commonly used to treat inflammatory conditions and has been report…
View article: Impact of laparoscopic approach on volumetric and functional liver recovery in advanced hepatectomy
Impact of laparoscopic approach on volumetric and functional liver recovery in advanced hepatectomy Open
View article: Effectiveness of on-demand acceptance and commitment training for burnout and well-being in Japanese medical students: protocol for a nationwide randomised controlled trial (BEACON Study)
Effectiveness of on-demand acceptance and commitment training for burnout and well-being in Japanese medical students: protocol for a nationwide randomised controlled trial (BEACON Study) Open
Introduction Burnout and reduced well-being are highly prevalent among Japanese medical students during clinical training. Scalable, evidence-based interventions are urgently needed. This protocol outlines a nationwide randomised controlle…
View article: Quantitative Evaluation of Healthcare Information Provided to Patients with Lung Cancer: Patient Satisfaction Survey of The Japan Lung Cancer Society
Quantitative Evaluation of Healthcare Information Provided to Patients with Lung Cancer: Patient Satisfaction Survey of The Japan Lung Cancer Society Open
Background: Healthcare professionals are increasingly providing medical information to patients. However, few objective evaluations of the information’s usefulness exist. This study posited that analyzing objective, quantified data facilit…
View article: Automating the data extraction process for systematic reviews using GPT-4o and o3
Automating the data extraction process for systematic reviews using GPT-4o and o3 Open
Large language models have shown promise for automating data extraction (DE) in systematic reviews (SRs), but most existing approaches require manual interaction. We developed an open-source system using GPT-4o to automatically extract dat…
View article: Efficacy of ciclosporin monotherapy in non‐severe aplastic anaemia not requiring transfusions: Results from a multicentre phase <scp>II</scp> study
Efficacy of ciclosporin monotherapy in non‐severe aplastic anaemia not requiring transfusions: Results from a multicentre phase <span>II</span> study Open
Summary The efficacy of ciclosporin (CsA) to treat transfusion‐independent non‐severe aplastic anaemia (TI‐NSAA) has not yet been systematically evaluated. We conducted a prospective trial in patients with TI‐NSAA treated with CsA monother…
View article: Development and evaluation of prompts for a large language model to screen titles and abstracts in a living systematic review
Development and evaluation of prompts for a large language model to screen titles and abstracts in a living systematic review Open
Background Living systematic reviews (LSRs) maintain an updated summary of evidence by incorporating newly published research. While they improve review currency, repeated screening and selection of new references make them labourious and …
View article: A prospective, randomized, double-blind, placebo-controlled trial of the Kampo formula daiobotanpito combined with antibiotic therapy for acute diverticulitis
A prospective, randomized, double-blind, placebo-controlled trial of the Kampo formula daiobotanpito combined with antibiotic therapy for acute diverticulitis Open
Daiobotanpito (DBT) is a Kampo formula traditionally used to treat abscesses in intestinal disorders. This double-blind, multicenter, randomized controlled trial was conducted at participating hospitals in Japan. Patients with CT-proven mo…
View article: A multicenter Phase II study of mFOLFOX6 plus nivolumab for gastric cancer with severe peritoneal metastases: WJOG16322G
A multicenter Phase II study of mFOLFOX6 plus nivolumab for gastric cancer with severe peritoneal metastases: WJOG16322G Open
Advanced gastric cancer (AGC) patients with severe peritoneal metastases (SPM), characterized by massive ascites and/or inadequate oral intake, have a poor prognosis with the median overall survival of around 7 months, even when treated wi…
View article: Treatment of Intermediate‐Risk Hepatoblastoma Using a Combined Cisplatin and Doxorubicin (PLADO) Regimen and Optimized Surgical Resection
Treatment of Intermediate‐Risk Hepatoblastoma Using a Combined Cisplatin and Doxorubicin (PLADO) Regimen and Optimized Surgical Resection Open
Background Complete resection of the primary tumor is critical for the survival of children with hepatoblastomas (HBs). This prospective clinical study aimed to clarify the outcome of a chemotherapy regimen comprising cisplatin and doxorub…
View article: Prognostic Benefit of Segmentectomy for Patients with Low Muscle Mass in Early-Stage Lung Cancer
Prognostic Benefit of Segmentectomy for Patients with Low Muscle Mass in Early-Stage Lung Cancer Open
Background Although segmentectomy is less invasive than lobectomy, little is known about the effect of these procedures on postoperative outcomes of patients with low muscle mass. This study examined the postoperative prognosis of patients…
View article: Intensity-Modulated Radiotherapy for Locally Advanced Lung Cancer in the Immunotherapy Era: A Prospective Study WJOG12019L
Intensity-Modulated Radiotherapy for Locally Advanced Lung Cancer in the Immunotherapy Era: A Prospective Study WJOG12019L Open
University Hospital Medical Information Network database ID: UMIN000038366.
View article: Radiotherapy-Free Pembrolizumab Combined with Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer with Pd-L1 TPS ≥50%: A Phase II Study (Evolution Trial: WJOG11819L)
Radiotherapy-Free Pembrolizumab Combined with Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer with Pd-L1 TPS ≥50%: A Phase II Study (Evolution Trial: WJOG11819L) Open
View article: Population Pharmacokinetics of Tamibarotene in Pediatric and Young Adult Patients with Recurrent or Refractory Solid Tumors
Population Pharmacokinetics of Tamibarotene in Pediatric and Young Adult Patients with Recurrent or Refractory Solid Tumors Open
Tamibarotene is a synthetic retinoid that inhibits tumor cell proliferation and promotes differentiation. We previously reported on the safety and tolerability of tamibarotene in patients with recurrent or refractory solid tumors. Therefor…
View article: Upfront or delayed surgery in resectable hepatoblastoma: analysis from the children’s hepatic tumors international collaboration database
Upfront or delayed surgery in resectable hepatoblastoma: analysis from the children’s hepatic tumors international collaboration database Open
European Network for Cancer Research in Children and Adolescents, funded through the Framework Program 7 of the European Commission; Children's Oncology Group Cure Search grant contributed by the Hepatoblastoma Foundation; Practical Resear…
View article: Phase 2 study of glucarpidase in patients with delayed methotrexate elimination after high-dose methotrexate therapy
Phase 2 study of glucarpidase in patients with delayed methotrexate elimination after high-dose methotrexate therapy Open
View article: A Phase II Study of FOLFIRI Plus Ziv-Aflibercept After Trifluridine/Tipiracil Plus Bevacizumab in Patients with Metastatic Colorectal Cancer: WJOG 11018G
A Phase II Study of FOLFIRI Plus Ziv-Aflibercept After Trifluridine/Tipiracil Plus Bevacizumab in Patients with Metastatic Colorectal Cancer: WJOG 11018G Open
jRCTs041190100.
View article: A Multi-Institutional, Randomized, Phase III Trial Comparing Anatomical Segmentectomy and Lobectomy for Clinical Stage IA3 Pure-Solid Non–Small-Cell Lung Cancer: West Japan Oncology Group Study WJOG16923L (STEP UP Trial)
A Multi-Institutional, Randomized, Phase III Trial Comparing Anatomical Segmentectomy and Lobectomy for Clinical Stage IA3 Pure-Solid Non–Small-Cell Lung Cancer: West Japan Oncology Group Study WJOG16923L (STEP UP Trial) Open
View article: EP211/#383 Current perceptions of the role of nurses in cancer clinical trials
EP211/#383 Current perceptions of the role of nurses in cancer clinical trials Open
Introduction Clinical (bedside) nurses play a crucial role in supporting cancer patients in making decisions regarding clinical trials, but this role is currently not being fulfilled sufficiently. The purpose of this study was to clarify t…
View article: A Phase 2 Single-Arm Study of Osimertinib for Radiotherapy-Naive Central Nervous System Metastasis NSCLC: Results for the First-Line Cohort of the OCEAN Study (LOGIK 1603/WJOG 9116L)
A Phase 2 Single-Arm Study of Osimertinib for Radiotherapy-Naive Central Nervous System Metastasis NSCLC: Results for the First-Line Cohort of the OCEAN Study (LOGIK 1603/WJOG 9116L) Open
UMIN identifier: UMIN000024218. jRCT identifier: jRCTs071180017.
View article: 1292MO A phase II study of daily carboplatin plus irradiation followed by durvalumab for unresectable III non-small cell lung cancer patients with PS 2 or elderly (≧75 years): NEJ039A
1292MO A phase II study of daily carboplatin plus irradiation followed by durvalumab for unresectable III non-small cell lung cancer patients with PS 2 or elderly (≧75 years): NEJ039A Open
View article: Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial)
Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial) Open
Background Hormone receptor (HR)-positive breast cancer is a disease for which no immune checkpoint inhibitors have shown promise as effective therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors synergistically increased the eff…
View article: Pulmonary Pleomorphic Carcinoma: Its Clinical Behavior, Prognostic Factor, and Keys to Treatment
Pulmonary Pleomorphic Carcinoma: Its Clinical Behavior, Prognostic Factor, and Keys to Treatment Open
Objective. Due to its rarity, the clinical behaviour of pulmonary pleomorphic carcinoma has not been elucidated. This study aimed to investigate the prognosis and prognostic factors of pulmonary pleomorphic carcinoma, especially factors as…
View article: Impact of conversion surgery after chemotherapy in patients with initially unresectable and recurrent biliary tract cancer
Impact of conversion surgery after chemotherapy in patients with initially unresectable and recurrent biliary tract cancer Open
Purpose Gemcitabine, cisplatin, and S‐1 chemotherapy was superior to gemcitabine and cisplatin chemotherapy for progression‐free survival and overall survival for unresectable and recurrent biliary tract cancer in a randomized phase III tr…
View article: Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B)
Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B) Open
View article: Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy
Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy Open
Chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck cancer; however, CRT may cause post-treatment dysphagia. Transcutaneous electrical sensory stimulation (TESS), developed in recent years for swallowing re…
View article: Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy
Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy Open
Chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck cancer; however, CRT may cause post-treatment dysphagia. Transcutaneous electrical sensory stimulation (TESS), developed in recent years for swallowing re…
View article: A Phase 2, Prospective, Multicenter, Single-Arm Trial of Transarterial Chemoembolization Therapy in Combination Strategy with Lenvatinib in Patients with Unresectable Intermediate-Stage Hepatocellular Carcinoma: TACTICS-L Trial
A Phase 2, Prospective, Multicenter, Single-Arm Trial of Transarterial Chemoembolization Therapy in Combination Strategy with Lenvatinib in Patients with Unresectable Intermediate-Stage Hepatocellular Carcinoma: TACTICS-L Trial Open
Introduction: Transarterial chemoembolization (TACE) is the standard treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC), but recurrence after TACE is common. The present phase 2, prospective, multice…
View article: Pharmacokinetics and Pharmacodynamics of Glucarpidase Rescue Treatment After High-dose Methotrexate Therapy Based on Modeling and Simulation
Pharmacokinetics and Pharmacodynamics of Glucarpidase Rescue Treatment After High-dose Methotrexate Therapy Based on Modeling and Simulation Open
We determined a recommended glucarpidase dose of 50 U/kg to be ethically acceptable. A rebound in the serum concentration of methotrexate may be observed in many patients after the administration of glucarpidase, and long-term monitoring (…