Koichi Yanaba
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View article: Perspective to precision medicine in scleroderma
Perspective to precision medicine in scleroderma Open
Systemic sclerosis (SSc) is a rare and heterogeneous disease with no relevant environmental trigger or significant responsible gene. It has been and will continue to be difficult to identify large enough patients to conduct classic populat…
View article: Relationship between the Degrees of Itch and Serum Lipocalin-2 Levels in Patients with Psoriasis
Relationship between the Degrees of Itch and Serum Lipocalin-2 Levels in Patients with Psoriasis Open
Background . Lipocalin-2 (LCN2), a protein secreted mainly by activated neutrophils, has been associated with neurodegeneration, obesity, and inflammatory responses. Serum LCN2 concentration has been reported elevated in patients with psor…
View article: Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis
Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis Open
Signaling through coinhibitory receptors downregulates the immune response to prevent excessive immune activation and maintain optimal immunity and tolerance. The aim of this study was to examine the levels of the soluble forms of coinhibi…
View article: Corrigendum to “IL-10-producing regulatory B cells are decreased in patients with psoriasis” [J. Dermatol. Sci. 81 (2016) 93–100]
Corrigendum to “IL-10-producing regulatory B cells are decreased in patients with psoriasis” [J. Dermatol. Sci. 81 (2016) 93–100] Open
View article: Anti‐<scp>PM</scp>/Scl antibody‐positive dermatomyositis in a Japanese patient: a case report and review of the literature
Anti‐<span>PM</span>/Scl antibody‐positive dermatomyositis in a Japanese patient: a case report and review of the literature Open
Dear Editor, Anti-PM/Scl (polymoyositis/scleroderma) antibodies recognize two major components, PM/Scl100 and PM/Scl75.1 They are detected in approximately 25% of patients with overlap syndrome of PM and systemic sclerosis (SSc), 3–13% of …
View article: Suppressive Effects of Mesenchymal Stem Cells in Adipose Tissue on Allergic Contact Dermatitis
Suppressive Effects of Mesenchymal Stem Cells in Adipose Tissue on Allergic Contact Dermatitis Open
The present findings suggest that MSCs in adipose tissue may contribute to the self-limiting course of ACD through decreased expression of IFN-γ, but not through increased expression of IL-10.
View article: Serum C‐reactive protein levels in Japanese patients with psoriasis and psoriatic arthritis: Long‐term differential effects of biologics
Serum C‐reactive protein levels in Japanese patients with psoriasis and psoriatic arthritis: Long‐term differential effects of biologics Open
Psoriasis has been shown to accompany systemic inflammation. We aimed to examine serum C‐reactive protein ( CRP ) levels in Japanese psoriatic patients, and to elucidate their long‐term as well as short‐term changes by treatment with diffe…
View article: Correlation of serum pro-cathepsin B levels with clinical features in patients with dcSSc and lcSSc.
Correlation of serum pro-cathepsin B levels with clinical features in patients with dcSSc and lcSSc. Open
Unless noted otherwise, values are percentages. dcSSc, diffuse cutaneous systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis; MRSS, modified Rodnan total skin thickness score; DLco, diffuse capacity for carbon monoxide; VC, vit…
View article: IL-10-producing regulatory B cells are decreased in patients with psoriasis
IL-10-producing regulatory B cells are decreased in patients with psoriasis Open
View article: Cutaneous plasmacytosis successfully treated with narrowband ultraviolet B irradiation therapy
Cutaneous plasmacytosis successfully treated with narrowband ultraviolet B irradiation therapy Open
View article: Anti‐transcription intermediary factor‐1γ/α/β antibody‐positive dermatomyositis associated with multiple panniculitis lesions
Anti‐transcription intermediary factor‐1γ/α/β antibody‐positive dermatomyositis associated with multiple panniculitis lesions Open
Dear Editor, Polymyositis and dermatomyositis are generally considered to be autoimmune disorders because of the presence of various autoantibodies against nuclear and/or cytoplasmic antigens, including antibodies that react with aminoacyl…
View article: A case of eccrine porocarcinoma with vascular invasion and multiple lymph node metastasis
A case of eccrine porocarcinoma with vascular invasion and multiple lymph node metastasis Open
69歳，女性。約10年前から右臀部に紅色結節がみられるも，自覚症状を伴わないため放置していた。約2年前から急激に増大したため，当科を受診した。初診時，右臀部に55mm×50mm大の角化を伴わない暗紫紅色腫瘍がみられた。腫瘤の近傍に約1cm大の紅色結節を伴っていた。身体学的所見として，右鼠径部のリンパ節の腫脹，右下腿の浮腫を認めた。病理組織学的には，表皮と連続性に比較的小型の異型を伴う類円形細胞の脂肪織への浸潤がみられたことから脈管浸潤を伴った悪性エクリン汗孔腫と診断した。全…