Koichiro Sato
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View article: Single‑center retrospective study of factors associated with early discontinuation of tumor‑treating fields therapy in glioblastoma
Single‑center retrospective study of factors associated with early discontinuation of tumor‑treating fields therapy in glioblastoma Open
Glioblastoma (GBM) is the most aggressive primary malignant tumor of the adult central nervous system with poor survival outcomes despite multimodal standard treatment. Tumor-treating fields (TTFields) therapy prolongs survival in patients…
View article: Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes
Effect of a Multifactorial Intervention on Retinopathy in People With Type 2 Diabetes Open
Importance Prevention of diabetic retinopathy is important to keep vision and quality of life. Objective To examine the effects of an intensive multifactorial intervention and hypoglycemia on retinopathy in people with type 2 diabetes. Des…
View article: Return to work and factors influencing recovery after endoscopic transsphenoidal surgery for hypothalamic and pituitary tumors
Return to work and factors influencing recovery after endoscopic transsphenoidal surgery for hypothalamic and pituitary tumors Open
This study investigated the return-to-work (RTW) rates and associated factors following endoscopic transsphenoidal surgery (eTSS) among patients with pituitary and hypothalamic tumors in Japan. The primary research question aimed to determ…
View article: Visceral Fat Associated with Worsening of Recurrent Esophageal Varices in Alcoholic/Nonalcoholic Steatohepatitis-Related Liver Cirrhosis
Visceral Fat Associated with Worsening of Recurrent Esophageal Varices in Alcoholic/Nonalcoholic Steatohepatitis-Related Liver Cirrhosis Open
Worsening of variceal recurrence was observed in high visceral fat patients in ASH/NASH-LC but not in viral LC. Furthermore, high visceral fat was an independent predictor associated with variceal recurrence.
View article: Neuroendoscopic cyst fenestration for delayed enlargement of perianeurysmal cyst formation through long-term follow-up after endovascular treatment: A case report and review of literature
Neuroendoscopic cyst fenestration for delayed enlargement of perianeurysmal cyst formation through long-term follow-up after endovascular treatment: A case report and review of literature Open
Background: Perianeurysmal cyst formation after endovascular treatment of cerebral aneurysms is a rare complication; however, the number of reports has gradually increased in recent years due to the development of several endovascular trea…
View article: Scoring system for prediction of mortality after endoscopic ligation in esophageal variceal bleeding
Scoring system for prediction of mortality after endoscopic ligation in esophageal variceal bleeding Open
Liver cirrhosis (LC) is the final stage of chronic liver disease. It is classified as compensated or decompensated cirrhosis based on the presence or absence of jaundice, ascites, encephalopathy, and gastrointestinal bleeding including eso…
View article: Outcomes and Recurrence Rate of Esophageal Varices after Endoscopic Treatment in Patients with Alcoholic Cirrhosis and Viral Cirrhosis
Outcomes and Recurrence Rate of Esophageal Varices after Endoscopic Treatment in Patients with Alcoholic Cirrhosis and Viral Cirrhosis Open
When limited to patients without a history of HCC, OS and the EV recurrence rate were comparable in patients with ALC who continued to consume alcohol and those with B/C-LC without viral control.
View article: Manual reduction for incarcerated obturator hernia
Manual reduction for incarcerated obturator hernia Open
Emergent surgery is a common approach for incarcerated obturator hernias, with high morbidity and mortality rates. Moreover, there have been reports of elective surgery cases after noninvasive manual reduction. For a decade, the initial ap…
View article: Computer-aided diagnosis of early-stage colorectal cancer using nonmagnified endoscopic white-light images (with videos)
Computer-aided diagnosis of early-stage colorectal cancer using nonmagnified endoscopic white-light images (with videos) Open
A CADx system developed with endoscopic white-light images showed excellent per-lesion specificity and accuracy for T1b lesion diagnosis, equivalent to experts and superior to trainees. (Clinical trial registration number: UMIN000037053.).
View article: Oxidative stress induces <i>MUC5AC</i> expression through mitochondrial damage‐dependent <scp>STING</scp> signaling in human bronchial epithelial cells
Oxidative stress induces <i>MUC5AC</i> expression through mitochondrial damage‐dependent <span>STING</span> signaling in human bronchial epithelial cells Open
Oxidative stress increases the production of the predominant mucin MUC5AC in airway epithelial cells and is implicated in the pathogenesis of bronchial asthma and chronic obstructive pulmonary disease. Oxidative stress impairs mitochondria…
View article: Enlargement of the Spleen Index Is a Predictor of the Occurrence of Esophageal Varices and Hepatocellular Carcinoma after Administering Direct-acting Antiviral Agents
Enlargement of the Spleen Index Is a Predictor of the Occurrence of Esophageal Varices and Hepatocellular Carcinoma after Administering Direct-acting Antiviral Agents Open
Objective Direct-acting antiviral agents (DAAs) can eliminate hepatitis C virus at a high rate, although the long-term incidence of portal hypertension and hepatocellular carcinoma (HCC) has not yet been elucidated. In this observational s…
View article: CQ<sup>2</sup> Is oral immunotherapy more efficient than a conventional elimination diet in patients with IgE-dependent cow's milk allergy?
CQ<sup>2</sup> Is oral immunotherapy more efficient than a conventional elimination diet in patients with IgE-dependent cow's milk allergy? Open
IgE依存性牛乳アレルギーにおける経口免疫療法(OIT)が牛乳の完全除去の継続よりも有用かどうか,システマティックレビュー(SR)により検討した.検索期間が2012年10月1日までの先行のSRから無作為化比較試験(RCT)を抽出し,それ以後2019年3月までのRCTをCENTRAL,MEDLINE,Embase,医学中央雑誌から追加検索した.既報のSRから5報のRCTを選択し,4報のRCTを追加で選択した.摂取量の増加した患者数,日常摂取量(200mL)への脱感作を得られた…
View article: A case of rhabdomyoma occurring in the tongue
A case of rhabdomyoma occurring in the tongue Open
Rhabdomyoma is a rare benign tumor classified as either cardiac or extracardic rhabdomyoma. Extracardiac rhabdomyoma is histopathologically categorized into adult, fetal, and genital types. Here we report a case of a 61-year-old man with a…
View article: Expression of Leucine-rich Repeat-containing Protein 32 Following Lymphocyte Stimulation in Patients with Non-IgE-mediated Gastrointestinal Food Allergies.
Expression of Leucine-rich Repeat-containing Protein 32 Following Lymphocyte Stimulation in Patients with Non-IgE-mediated Gastrointestinal Food Allergies. Open
The lymphocyte stimulation test (LST) facilitates the diagnosis of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs). However, LSTs require large volumes of blood and prolonged culture durations. Recently, we found that IL2…
View article: A case of severe odontogenic infection in which refeeding syndrome could be avoided by intervention of the nutritional support team
A case of severe odontogenic infection in which refeeding syndrome could be avoided by intervention of the nutritional support team Open
We report the case of a high-risk patient with refeeding syndrome (RFS) caused by severe odontogenic infection. An 80-year-old man visited our hospital because of a 10-day history of an eating disorder caused by left-sided throat pain. The…
View article: Is house dust mite allergen-specific immunotherapy useful for management of pediatric asthma patients?
Is house dust mite allergen-specific immunotherapy useful for management of pediatric asthma patients? Open
小児気管支喘息患者に対してダニアレルゲン特異的免疫療法（皮下免疫療法，舌下免疫療法）とプラセボを比較した試験は16編あり，その中で皮下免疫療法では喘息症状，頓用薬の使用，全身性ステロイド投与，長期管理薬の使用量，呼吸機能において，舌下免疫療法では喘息症状，呼吸機能においてダニアレルゲン特異的免疫療法が効果的であることが示された．しかしエビデンスレベルが総じて低く，日本人小児を対象とした試験がなかった．また本邦では皮下免疫療法は喘息への保険適応があるものの，舌下免疫療法は現時…
View article: Regional differences in the prevalence of oral allergy syndrome among Japanese children: A questionnaire-based survey
Regional differences in the prevalence of oral allergy syndrome among Japanese children: A questionnaire-based survey Open
Herein, oral symptoms were more likely to occur in patients with SAR than in those without SAR. The prevalence of SAR and food-induced oral symptoms significantly differed among the regions, suggesting they might be affected by regional di…
View article: Insect allergens
Insect allergens Open
昆虫アレルゲンはその曝露経路により1）吸入によるもの，2）刺咬によるもの，3）接触によるものに大別される．1）としてはゴキブリが，2）としてはハチ毒が代表的アレルゲンとして知られている．ゴキブリ抗原は気管支喘息の重要なアレルゲンである．コンポーネントであるTropomyosinは汎アレルゲンであり，ゴキブリ間およびエビなどの甲殻類およびチリダニといった節足動物間での交差反応性を示し，食物アレルギーや舌下免疫療法の分野でも注目されている．ハチ毒には多種のアレルゲンが含まれ，ア…
View article: Generative methods for deriving diverse curved surface by stacking the cross-sectional shape
Generative methods for deriving diverse curved surface by stacking the cross-sectional shape Open
This paper described the proposal of the generative method for diverse curved surface shape by stacking the cross-sectional shape for constructing the foundation in the generative method focused on sensitivity. To identify the relationship…
View article: Emergence and Optimality in Generative Design Research
Emergence and Optimality in Generative Design Research Open
This paper described a framework of the Generative Design (GD) research area and the issues in the GD research focused on emergence based on the analysis of the characteristics of the GD research area and the viewpoint of the design method…
View article: Generation of diverse curved surface shape by controlling the cross-sectional shape
Generation of diverse curved surface shape by controlling the cross-sectional shape Open
This paper described the proposal of the generative method for diverse curved surface shape by controlling the cross-sectional shape for constructing the foundation in the generative method focused on sensitivity. The experiment for impres…
View article: Severity scales of non-IgE-mediated gastrointestinal food allergies in neonates and infants
Severity scales of non-IgE-mediated gastrointestinal food allergies in neonates and infants Open
Classification and determination of the severity of non-IgE-GI-FAs in neonates and infants may not only contribute to elucidation of the pathogenesis but may also be useful in the clinical setting.
View article: Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection
Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection Open
An 81-year-old woman developed liver dysfunction after two months' treatment with direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection. She was positive for serum anti-nuclear antibody, with an elevated immunoglobu…
View article: Characteristics of Research for Engineering Design and Design within Multispace Design Model
Characteristics of Research for Engineering Design and Design within Multispace Design Model Open
This study analyses the characteristics and the differences of research in engineering design domain and design (industrial design) domain and explores the future research issues to be addressed for enhancing design integration between eng…
View article: Feature analysis of generative design research focused on time series variation
Feature analysis of generative design research focused on time series variation Open
This paper describes a feature analysis of generative design researches focused on time series variation. The time series variation of those are organized, and time series changes of the objectives, methods used and solutions are analyzed.…