Explanipedia

Prediction of the risk of transplant rejection based on RNA sequencing data of PBMCs before transplantation Open

Yu Gong, Yuan Wang, Kazuyoshi Takeda, Saori Hirota, Yui Maehara , et al. · 2025

Activation of anti-donor CD8 alloimmune response in clinically diagnosed acute rejection early after living-donor lobar lung transplantation and its impact on outcome Open

Satona Tanaka, Naoki Tanimine, Akiyoshi Nakakura, Koichiro Uchida, Ichiro Sakanoue , et al. · 2025

Early lung graft infiltration after LDLLT increases the risk of the early development of CALD. Augmented anti-donor CD8 + response was also associated with graft infiltration, which could not be predicted from HLA mismatches but could be m…

Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance Open

Helen Stark, Quan Yao Ho, Amy Cross, Alessandro Alessandrini, Alice Bertaina , et al. · 2025

Intranasal Immunization with Nasal Immuno-Inducible Sequence-Fused Antigens Elicits Antigen-Specific Antibody Production Open

Hiraku Sasaki, Yoshio Suzuki, Kodai Morimoto, Kazuyoshi Takeda, Koichiro Uchida , et al. · 2024

Intranasal immunization is one of the most effective methods for eliciting lung mucosal immunity. Multiple intranasal immunization with bacterial polypeptide, termed as a modified PnxIIIA (MP3) protein, is known to elicit production of a s…

Blockade of CD80/CD86-CD28 co-stimulation augments the inhibitory function of peptide antigen-specific regulatory T cells Open

Yui Maehara, Kazuyoshi Takeda, Kyoko Tsuji-YOGO, Kodai Morimoto, Masaki Harada , et al. · 2024

Mixed lymphocyte culture under the blockade of CD80/CD86-CD28 co-stimulation induces anergic (completely hyporesponsive) T cells with immune suppressive function (inducible suppressing T cells: iTS cells). Previously, iTS cell therapy has …

Study of Railway Equipment Maintenance considering Risk Assessment Open

Ken TAKASAKI, Atsushi Mizoguchi, Yuki Oka, Koichiro Uchida, Hiroto TAKEHARA · 2024

Phase 1/2 donor antigen specific regulatory T cell-based cell therapy clinical trial to induce operational tolerance in living donor liver transplant patients Open

Koichiro Uchida, Akio Saiura, Akinobu Taketomi, Etsuro Hatano, Susumu Eguchi , et al. · 2023

Koichiro Uchida, Akio Saiura, Akinobu Taketomi, Etsuro Hatano, Susumu Eguchi, Hideki Ohdan, Hiroto Egawa, Kazuyoshi Takeda, Ko Okumura. Korean J Transplant 2023;37:218. https://doi.org/10.4285/ATW2023.F-8092

Staphylococcus aureus δ-toxin present on skin promotes the development of food allergy in a murine model Open

Hiromichi Yamada, Ayako Kaitani, Kumi Izawa, Tomoaki Ando, Anna Kamei , et al. · 2023

Background Patients with food allergy often suffer from atopic dermatitis, in which Staphylococcus aureus colonization is frequently observed. Staphylococcus aureus δ-toxin activates mast cells and promotes T helper 2 type skin inflammatio…

Standardization of lymphoapheresis in living donor liver transplant patients for the engineered antigen specific regulatory T cell product for tolerance induction Open

Yui Maehara, Koichiro Uchida, Kazuyoshi Takeda, Ko Okumura · 2022

Background:We are developing antigen specific regulatory T cell product that aims to suppress posttransplant rejections in a donor antigen-specific manner and induce immune tolerance and conducting multicenter clinical trial in Japan.Thoug…

Anti-CD80/86 antibodies inhibit inflammatory reaction and improve graft survival in a high-risk murine corneal transplantation rejection model Open

Jun Zhu, Takenori Inomata, Masahiro Nakamura, Keiichi Fujimoto, Yasutsugu Akasaki , et al. · 2022

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice Open

Jun Zhu, Takenori Inomata, Keiichi Fujimoto, Koichiro Uchida, Kenta Fujio , et al. · 2021

The ex vivo-induced BM-MDSCs have suppressive effects on allogeneic immune responses and prolong corneal allograft survival via the iNOS pathway, indicating that they may be a potential therapeutic tool for corneal transplantation.

Analysis of therapeutic potential of monocytic myeloid-derived suppressor cells in cardiac allotransplantation Open

Keiichi Fujimoto, Koichiro Uchida, Enzhi Yin, Jun Zhu, Yuko Kojima , et al. · 2021

Recipient-derived Mo-MDSCs are most effective in prolonging graft survival via inhibiting T cell response and nTreg infiltration.

PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages Open

Takuya Yashiro, Machiko Yamamoto, Sanae Araumi, Mutsuko Hara, Kyoko Yogo , et al. · 2021

NLRP3 inflammasomes play crucial roles in the initiation of host defense by converting pro-Caspase-1 to mature Caspase-1, which in turn processes immature IL-1β and IL-18 into their biologically active forms. Although NLRP3 expression is r…

Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury Open

Enzhi Yin, Takeshi Fukuhara, Kazuyoshi Takeda, Yuko Kojima, Kyoko Fukuhara , et al. · 2021

Differential Lipid Recognition by Mouse versus Human CD300f, Inhibiting Passive Cutaneous Anaphylaxis, Depends on a Single Amino Acid Substitution in its Immunoglobulin-Like Domain Open

Kumi Izawa, Ayako Kaitani, Tomoaki Ando, Akie Maehara, Masakazu Nagamine , et al. · 2019

CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity Open

Naoko Negishi, Takehito Sato, Yumi Yamashita-Kanemaru, Kazuko Shibuya, Koichiro Uchida , et al. · 2018

The precise mechanism of how the regulatory T cell population elicits and maintains tolerant state in activated T cells is poorly understood. To address this issue, we established an in vitro coculture system using mouse T cells and showed…

The effect of Anti-CD80/86 antibody on regulatory T cells in murine corneal transplantation. Open

Keiichi Fujimoto, Takenori Inomata, Koichiro Uchida, Yuichi Okumura, Akira Murakami · 2018

Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells Open

Ayako Kaitani, Kumi Izawa, Akie Maehara, Masamichi Isobe, Ayako Takamori , et al. · 2018

Table of Contents Open

Stefania Jabło, Marek Haftek, Sarah Katz, Thomas Krieg, Xiumin Wu , et al. · 2018

The CD300e molecule in mice is an immune-activating receptor Open

Masamichi Isobe, Kumi Izawa, Masahiro Sugiuchi, Tamami Sakanishi, Ayako Kaitani , et al. · 2018

CD300 molecules (CD300s) belong to paired activating and inhibitory receptor families, which mediate immune responses. Human CD300e (hCD300e) is expressed in monocytes and myeloid dendritic cells and transmits an immune-activating signal b…

Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment Open

Kumi Izawa, Akie Maehara, Masamichi Isobe, Yuka Yasuda, Makoto Urai , et al. · 2017

Sepsis is a serious clinical problem. Negative regulation of innate immunity is associated with sepsis progression, but the underlying mechanisms remains unclear. Here we show that the receptor CD300f promotes disease progression in sepsis…

Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor Open

Kyoko Oh‐oka, Yuko Kojima, Koichiro Uchida, Kimiko Yoda, Kayoko Ishimaru , et al. · 2017

We propose a novel anti-inflammatory mechanism of mesalamine for colitis: induction of Tregs in the colon via the AhR pathway, followed by TGF-β activation.

Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation Open

Emiko Shiba, Kumi Izawa, Ayako Kaitani, Masamichi Isobe, Akie Maehara , et al. · 2017

LPS triggers inflammatory responses; however, the negative regulation of LPS responses in vivo remains poorly understood. CD300f is an inhibitory receptor among the CD300 family of paired activating and inhibitory receptors. We have…

A Clinical Trial Aiming at Tolerance Induction by Adoptive Transfer of Ex Vivo-Induced, Donor-Specific Treg-Like Cells in Clinical Kidney Transplantation Open

Satoshi Teraoka, Ichiro Koyama, Hisashi Bashuda, Koichiro Uchida, Makoto Tonsho , et al. · 2017

Pharmacologic inhibition of Notch signaling suppresses food antigen–induced mucosal mast cell hyperplasia Open

Asuka Honjo, Nobuhiro Nakano, Susumu Yamazaki, Mutsuko Hara, Koichiro Uchida , et al. · 2016

Notch signaling contributes to differentiation and accumulation of MMCs in the intestinal mucosa. Thus inhibition of Notch signaling alleviates symptoms associated with experimental food allergy. These results raise the possibility that No…

Laparoscopic Major Liver Resection Open

Koichiro Uchida, CADER SONIA, Toshiyasu Kawahara · 2015

Laparoscopic liver resection (LLR) has several advantages over conventional open liver surgery. However, the indications for laparoscopic liver resection remain limited because of technical difficulties, hemorrhagic and embolic risks, and …

Distal Gastrectomy and D2 Lymph Node Dissection for Gastric Cancer after Coronary Bypass Grafting Using the Right Gastroepiploic Artery Open

Keiko Asai, Kei Ohara, Kimiharu Hasegawa, Kengo Kita, Koichiro Uchida , et al. · 2015

右胃大網動脈を用いた冠動脈バイパス術後に発症した胃癌に対して幽門側胃切除D2郭清を施行した1例を経験した．症例は74歳男性で，59歳時に冠動脈バイパス術の既往がある．73歳時，上部消化管内視鏡検査で胃前庭部小彎に約4 cm大0-IIc病変あり前医にてESDを施行し病理結果tub2，SM1，UL（–），ly（+），v（–），pHM0（2 mm），pVM1であった．手術と再発のリスクを検討し経過観察としたが1年後CTで幽門上リンパ節腫大を認めた．経皮的冠動脈形成術でgraftに…

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