Kok Hing Lim
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View article: Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease
Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease Open
The 2-stage diagnostic workflow integrating MRI-based risk stratification and plasma p-tau217 testing accurately identified individuals with Aβ PET positivity in early-stage AD, substantially reducing the need for additional biomarker test…
View article: The Prognostic Role of Pre-Treatment Neutrophil-to-Lymphocyte Ratio in an Asian Cohort of Patients with Oropharyngeal Squamous Cell Carcinoma
The Prognostic Role of Pre-Treatment Neutrophil-to-Lymphocyte Ratio in an Asian Cohort of Patients with Oropharyngeal Squamous Cell Carcinoma Open
Purpose: The neutrophil-to-lymphocyte ratio is a simple biomarker that reflects the balance between the systemic inflammatory and immunity status. Here we investigate the prognostic role of pre-treatment neutrophil-to-lymphocyte ratio (NLR…
View article: Combinatorial hypofractionated radiotherapy and pembrolizumab in anaplastic thyroid cancer
Combinatorial hypofractionated radiotherapy and pembrolizumab in anaplastic thyroid cancer Open
Objective Anaplastic thyroid cancer (ATC) is an aggressive disease associated with poor outcomes and resistance to therapies. Our study aim was to evaluate the activity of a combinatorial regimen of sandwich sequencing of pembrolizumab imm…
View article: Boosted abscopal effect from radiotherapy and pembrolizumab in anaplastic thyroid cancer: a mini-review and case report
Boosted abscopal effect from radiotherapy and pembrolizumab in anaplastic thyroid cancer: a mini-review and case report Open
This case demonstrates exceptional response to radiotherapy and anti-PD-1 immunotherapy in ATC, potentially illustrating the first known abscopal effect in ATC with this treatment.
View article: SINGLE CELL LANDSCAPE OF MULTICENTRIC CASTLEMAN DISEASE IN IDENTICAL TWINS
SINGLE CELL LANDSCAPE OF MULTICENTRIC CASTLEMAN DISEASE IN IDENTICAL TWINS Open
Idiopathic Multicentric Castleman Disease (iMCD) is a rare IL-6-driven hematological disorder characterized by systemic lymphadenopathy, elevated immunoglobulin levels, and prominent plasmacytosis in the bone marrow and lymph nodes. An unu…
View article: Rapidly Progressing Necrotic Hand Ulcer in a Patient with Angioimmunoblastic T-Cell Lymphoma
Rapidly Progressing Necrotic Hand Ulcer in a Patient with Angioimmunoblastic T-Cell Lymphoma Open
Mucormycosis is a fungal infection caused by opportunistic fungi of the phylum Glomeromycota, subphylum Mucormycotina. In developed countries, it affects patients with haematological malignancies undergoing chemotherapy and those who have …
View article: Dermatoscope of primary localized cutaneous nodular amyloidosis on hallux nail bed
Dermatoscope of primary localized cutaneous nodular amyloidosis on hallux nail bed Open
IntroductionPrimary localized cutaneous nodular amyloidosis (PLCNA) is the rarest form of cutaneous amyloidosis with a predilection for acral sites.1Woollons A. Black M.M. Nodular localized primary cutaneous amyloidosis: a long-term follow…
View article: Solitary leg ulcer in a renal transplant recipient
Solitary leg ulcer in a renal transplant recipient Open
A 44-year-old Asian woman presented 3 years after a kidney transplant with a 1-month history of a painful and enlarging lesion on the left shin. She was on 6.5 mg tacrolimus once daily, 360 mg mycophenolic acid twice a day, and 5 mg predni…
View article: Granular Cell Tumor of Esophagus: A Rare Disease of the Esophagus
Granular Cell Tumor of Esophagus: A Rare Disease of the Esophagus Open
Esophageal granular cell tumors (GCT) represent a rare entity of tumors of the esophagus. Patients with esophageal GCTs are usually asymptomatic, with the lesion most commonly presenting as an incidental finding on endoscopy. The GCTs of t…
View article: Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing
Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing Open
Opportunities for genetic testing are frequently missed due to low referral rates in patients with apparently sporadic PPGLs, particularly between ages 20-60.