Kokoro Shirai
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View article: Frequency of laughter and depression onset among older adults: A 6-year longitudinal study from the Japan Gerontological Evaluation Study
Frequency of laughter and depression onset among older adults: A 6-year longitudinal study from the Japan Gerontological Evaluation Study Open
Lower frequency of laughter in daily life was associated with an increased risk of depression onset in older adults. These findings suggest that frequent laughter may play a role in depression prevention in later life.
View article: Lifestyle-attributable burden of young-onset stroke in Chinese and global populations aged 20–54 years: A three decades comparative study ( 1990–2021 ) using Global Burden of Disease study data
Lifestyle-attributable burden of young-onset stroke in Chinese and global populations aged 20–54 years: A three decades comparative study ( 1990–2021 ) using Global Burden of Disease study data Open
The diverging trajectories of mortality and disability burdens underscore China's dual challenge: curbing substance-related mortality in young males while containing midlife disability escalation. Culturally tailored strategies addressing …
View article: Remembering Dr. Hideo Nigi
Remembering Dr. Hideo Nigi Open
View article: Healthy lifestyle factors outweigh influence of APOE genetic risk on extending cognitively healthy life expectancy among Chinese older adults: evidence from a nationwide cohort study
Healthy lifestyle factors outweigh influence of APOE genetic risk on extending cognitively healthy life expectancy among Chinese older adults: evidence from a nationwide cohort study Open
INTRODUCTION Understanding the interplay between genetic factors and lifestyle choices in cognitive health is crucial for enhancing late‐life quality. This study examines the effects of Apolipoprotein E (APOE) genotypes and healthy lifesty…
View article: Quick accomplishment and responsiveness were associated with a lower risk of mortality from cardiovascular disease among Japanese older men: the Japan Collaborative Cohort Study
Quick accomplishment and responsiveness were associated with a lower risk of mortality from cardiovascular disease among Japanese older men: the Japan Collaborative Cohort Study Open
Quick accomplishment was associated with a lower risk of CVD mortality. Quick accomplishment and responsiveness combined were inversely associated with CVD mortality risk among older men.
View article: Interventions for people living with dementia: updates from 2024 Lancet Commission
Interventions for people living with dementia: updates from 2024 Lancet Commission Open
Background The progressive nature of dementia and the complex needs means that people living with dementia require tailored approaches to address their changing care needs over time. These include physical multimorbidity, psychological, be…
View article: Triangulation to make decisions about what are modifiable risk factors and the new risk factors
Triangulation to make decisions about what are modifiable risk factors and the new risk factors Open
Background The 2020 Lancet Commission on dementia prevention, intervention and care estimated that up to 40% of dementia cases could be prevented by tackling 12 potentially modifiable risk factors, namely less education, hearing loss, hype…
View article: Diversity, Equity and Inclusivity‐ Low and Middle Income countries and the Lancet commission
Diversity, Equity and Inclusivity‐ Low and Middle Income countries and the Lancet commission Open
Background Data from high‐income countries (HICs) suggest a decline in age‐specific incidence rates of dementia. However, this has happened primarily in HICs, with low‐ and middle‐ income countries (LMICs) facing two main challenges: a hig…
View article: Potentially modifiable risk factors for dementia putting the evidence together: Total population attributable fraction
Potentially modifiable risk factors for dementia putting the evidence together: Total population attributable fraction Open
Background Our authors from around the world met to summarise the available knowledge, decide which potentially modifiable risk factors for dementia have compelling evidence and create the most comprehensive analysis to date for potentiall…
View article: Taiso practice and risk of functional disability and dementia among older adults in Japan: The JAGES cohort study
Taiso practice and risk of functional disability and dementia among older adults in Japan: The JAGES cohort study Open
View article: Sex-specific associations between socioeconomic status and ideal cardiovascular health among Korean adults: The Korea National Health and Nutrition Examination Survey, 2007–2017
Sex-specific associations between socioeconomic status and ideal cardiovascular health among Korean adults: The Korea National Health and Nutrition Examination Survey, 2007–2017 Open
Socioeconomic status (SES) has a considerable impact on cardiovascular health (CVH), which may differ by sex. We aimed to investigate sex-specific socioeconomic disparities in CVH among 31,141 individuals aged 25–64 years who participated …
View article: Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission Open
View article: Perceived Familial Financial Insecurity and Obesity Among Korean Adolescents During the COVID-19 Pandemic
Perceived Familial Financial Insecurity and Obesity Among Korean Adolescents During the COVID-19 Pandemic Open
While the COVID-19 pandemic presented a unique social context, our findings highlight that financially insecure adolescents were at an increased risk of obesity during the early phase of the pandemic. This underscores the need for obesity-…
View article: Socioeconomic Status Transition Throughout Life and Risk of Dementia
Socioeconomic Status Transition Throughout Life and Risk of Dementia Open
Importance Socioeconomic status (SES) is associated with dementia. However, the role of SES transitions in dementia is less explored; such evidence would be useful to understand whether social mobility is associated with healthy longevity …
View article: Navigating Hurdles: A Review of the Obstacles Facing the Development of the Pandemic Treaty
Navigating Hurdles: A Review of the Obstacles Facing the Development of the Pandemic Treaty Open
Introduction The emergence of the COVID-19 pandemic has served as a call for enhanced global cooperation and a more robust pandemic preparedness and response framework. As a result of this pressing demand, dialogues were initiated to estab…
View article: Associations between Supper Timing and Mortality from Cardiovascular Disease among People with and without Hypertension
Associations between Supper Timing and Mortality from Cardiovascular Disease among People with and without Hypertension Open
Irregular supper time was associated with an increased risk of CVD mortality. Supper timing could be a surrogate marker for CVD risk.
View article: A meeting report: celebration of the 40th anniversary and suggestions for the next decade of the Takemi Program
A meeting report: celebration of the 40th anniversary and suggestions for the next decade of the Takemi Program Open
View article: Physical Activity and Bladder Cancer Risk: Findings of the Japan Collaborative Cohort Study
Physical Activity and Bladder Cancer Risk: Findings of the Japan Collaborative Cohort Study Open
Purpose The association of physical activity with the risk of bladder cancer remains inconsistent among Asian populations. We aimed to examine the association in a large Japanese cohort.Materials and Methods In a population-based prospecti…
View article: Participation in Community Gathering Places and Subsequent Health and Well-Being: An Outcome-Wide Analysis
Participation in Community Gathering Places and Subsequent Health and Well-Being: An Outcome-Wide Analysis Open
Background and Objectives Evidence remains inadequate regarding the benefits of participation in community gathering places, which is Japan’s primary strategy for preventing functional disability in older adults, in other domains of health…
View article: Prevalence and trends of polypharmacy in U.S. adults, 1999–2018
Prevalence and trends of polypharmacy in U.S. adults, 1999–2018 Open
View article: Television Viewing Time and All-cause and Cardiovascular Disease Mortality Among Japanese Adults with and without a History of Stroke or Myocardial Infarction
Television Viewing Time and All-cause and Cardiovascular Disease Mortality Among Japanese Adults with and without a History of Stroke or Myocardial Infarction Open
Prolonged TV viewing time was associated with higher risks of all-cause and CVD mortality in stroke or MI survivors and in persons without a history of them. It may be recommended to reduce sedentary time for stroke or MI survivors, indepe…
View article: Association between android fat mass, gynoid fat mass and cardiovascular and all-cause mortality in adults: NHANES 2003–2007
Association between android fat mass, gynoid fat mass and cardiovascular and all-cause mortality in adults: NHANES 2003–2007 Open
Objectives Evidence of the relationship between android fat mass and gynoid fat mass with the mortality prediction is still limited. Current study analyzed the NHANES database to investigate the relationship between android fat mass, gynoi…
View article: Social participation and risk of developing dementia
Social participation and risk of developing dementia Open
The increasing number of people with dementia globally illustrates the urgent need to reduce dementia's scale and impact. Lifetime social participation may affect dementia risk by increasing cognitive reserve, and through brain maintenance…
View article: Childhood secondhand smoke exposure and respiratory disease mortality among never-smokers: the Japan collaborative cohort study for evaluation of cancer risk
Childhood secondhand smoke exposure and respiratory disease mortality among never-smokers: the Japan collaborative cohort study for evaluation of cancer risk Open
Background The main source of secondhand smoke (SHS) exposure during childhood occurs at home due to close family members who smoke. This study examined the association between childhood SHS exposure and the risk of respiratory disease mor…
View article: Subjective Happiness, Frequency of Laughter, and Hypertension: A Cross-Sectional Study Based on the Japan Gerontological Evaluation Study (JAGES)
Subjective Happiness, Frequency of Laughter, and Hypertension: A Cross-Sectional Study Based on the Japan Gerontological Evaluation Study (JAGES) Open
In recent years, positive psychological factors, such as subjective happiness and laughter, have been reported to be associated with cardiovascular disease. In this study, we examined the relationship of hypertension with subjective happin…
View article: Ambient PM2.5, ozone and mortality in Chinese older adults: A nationwide cohort analysis (2005–2018)
Ambient PM2.5, ozone and mortality in Chinese older adults: A nationwide cohort analysis (2005–2018) Open
View article: Laughter yoga as an enjoyable therapeutic approach for glycemic control in individuals with type 2 diabetes: A randomized controlled trial
Laughter yoga as an enjoyable therapeutic approach for glycemic control in individuals with type 2 diabetes: A randomized controlled trial Open
Background Laughter has been reported to have various health benefits. However, data on the long-term effects of laughter interventions on diabetes are limited. This study aimed to investigate whether laughter yoga can improve glycemic con…
View article: Frequency of Going Outdoors and Risk of Poor Oral Health Among Older Japanese Adults: A Longitudinal Cohort From the Japan Gerontological Evaluation Study
Frequency of Going Outdoors and Risk of Poor Oral Health Among Older Japanese Adults: A Longitudinal Cohort From the Japan Gerontological Evaluation Study Open
The frequency of going outdoors was inversely associated with the risk of poor oral health through several modifiable risk factors in the older population.
View article: Association of Blood Urea Nitrogen with Cardiovascular Diseases and All-Cause Mortality in USA Adults: Results from NHANES 1999–2006
Association of Blood Urea Nitrogen with Cardiovascular Diseases and All-Cause Mortality in USA Adults: Results from NHANES 1999–2006 Open
In the general population, there is little evidence of a link between blood urea nitrogen (BUN) and long-term mortality. The goal of this study was to explore whether higher BUN concentration is a predictor of cardiovascular disease (CVD) …
View article: Sex- and age-specific impacts of smoking, overweight/obesity, hypertension, and diabetes mellitus in the development of disabling dementia in a Japanese population
Sex- and age-specific impacts of smoking, overweight/obesity, hypertension, and diabetes mellitus in the development of disabling dementia in a Japanese population Open
A substantial burden of disabling dementia was attributable to smoking, and hypertension in both sexes and diabetes mellitus in women, which may require the management of these cardiovascular risk factors to prevent dementia.