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View article: Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP
Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP Open
Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-pho…
View article: Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP
Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP Open
Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-pho…
View article: A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy
A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy Open
Immunotargeting of tumor-specific antigens is a powerful therapeutic strategy. Immunotherapies directed at MHC-I complexes have expanded the scope of antigens and enabled the direct targeting of intracellular oncoproteins at the cell surfa…
View article: End-Binding E3 Ubiquitin Ligases Enable Protease Signaling
End-Binding E3 Ubiquitin Ligases Enable Protease Signaling Open
Post-translational modifications (PTMs) direct the assembly of protein complexes. In this context, proteolysis is a unique PTM because it is irreversible; the hydrolysis of the peptide backbone generates separate fragments bearing a new N …
View article: Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases Open
View article: Why recombinant antibodies — benefits and applications
Why recombinant antibodies — benefits and applications Open
Antibodies (Abs) are ubiquitous reagents for biological and biochemical research and are rapidly expanding into new therapeutic areas. They are one of the most important probes for determining how proteins function under normal and pathoph…
View article: Do diverse antifreeze protein structures bind ice by the same mechanism?
Do diverse antifreeze protein structures bind ice by the same mechanism? Open
Antifreeze proteins (AFPs) are characterized by their capacity to adsorb to the surface of ice crystals and prevent their growth.This adsorption lowers the freezing temperature of a solution below its melting point.AFPs have independently …
View article: Discovery and characterization of an antifreeze protein from Lake Ontario midges
Discovery and characterization of an antifreeze protein from Lake Ontario midges Open
View article: Modeling repetitive, non‐globular proteins
Modeling repetitive, non‐globular proteins Open
While ab initio modeling of protein structures is not routine, certain types of proteins are more straightforward to model than others. Proteins with short repetitive sequences typically exhibit repetitive structures. These repetitive sequ…
View article: Intermediate activity of midge antifreeze protein is due to a tyrosine‐rich ice‐binding site and atypical ice plane affinity
Intermediate activity of midge antifreeze protein is due to a tyrosine‐rich ice‐binding site and atypical ice plane affinity Open
An antifreeze protein ( AFP ) from a midge ( Chironomidae ) was recently discovered and modelled as a tightly wound disulfide‐braced solenoid with a surface‐exposed rank of stacked tyrosines. New isoforms of the midge AFP have been identif…
View article: Flies expand the repertoire of protein structures that bind ice
Flies expand the repertoire of protein structures that bind ice Open
Significance A previously unidentified insect antifreeze protein has been characterized in a fly. It is present in the adult stage of midges that emerge from fresh water in the spring and need protection from occasional night frosts. The m…