Kolin E. Rubel
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View article: Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis
Aging and frailty are associated with inflammatory endotypic shifts in patients with chronic rhinosinusitis Open
Key points Frailty and aging are associated with a shift toward non‐type 2 inflammation in chronic rhinosinusitis (CRS). Frailty‐related shifts in sinonasal inflammatory mediators may be linked to biological senescence. Understanding the r…
View article: Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis
Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis Open
Background Chronic rhinosinusitis (CRS) is thought to result from complex interactions between the host immune system, microbiota, and environmental exposures. Currently, there is limited data regarding the impact of ambient particulate ma…
View article: Inflammatory characteristics of central compartment atopic disease
Inflammatory characteristics of central compartment atopic disease Open
Background Central compartment atopic disease (CCAD) is an emerging phenotype of chronic rhinosinusitis with nasal polyposis (CRSwNP) characterized by prominent central nasal inflammatory changes. This study compares the inflammatory chara…
View article: Aerosol generation during routine rhinologic surgeries and <scp>in‐office</scp> procedures
Aerosol generation during routine rhinologic surgeries and <span>in‐office</span> procedures Open
Objective Cadaveric simulations have shown endonasal drilling and cautery generate aerosols, which is a significant concern for otolaryngologists during the COVID‐19 era. This study quantifies aerosol generation during routine rhinologic s…
View article: COVID‐19 Status Differentially Affects Olfaction: A Prospective Case‐Control Study
COVID‐19 Status Differentially Affects Olfaction: A Prospective Case‐Control Study Open
Objective The symptoms and long‐term sequelae of SARS‐CoV‐2 infection have yet to be determined, and evaluating possible early signs is critical to determine which patients should be tested and treated. The objective of this ongoing study …
View article: Droplet Exposure Risk to Providers From In‐Office Flexible Laryngoscopy: A COVID‐19 Simulation
Droplet Exposure Risk to Providers From In‐Office Flexible Laryngoscopy: A COVID‐19 Simulation Open
To provide data on risk of respiratory droplets from common otolaryngologic procedures during the COVID‐19 pandemic, a novel simulation of droplet exposure from flexible laryngoscopy was performed. After completion of a nasal symptom quest…
View article: Mitigation of Aerosols Generated During Rhinologic Surgery: A Pandemic‐Era Cadaveric Simulation
Mitigation of Aerosols Generated During Rhinologic Surgery: A Pandemic‐Era Cadaveric Simulation Open
Objective After significant restrictions initially due to the COVID‐19 pandemic, otolaryngologists have begun resuming normal clinical practice. However, the risk of SARS‐CoV‐2 transmission to health care workers through aerosolization and…
View article: Cadaveric Simulation of Otologic Procedures: An Analysis of Droplet Splatter Patterns During the COVID‐19 Pandemic
Cadaveric Simulation of Otologic Procedures: An Analysis of Droplet Splatter Patterns During the COVID‐19 Pandemic Open
Objective The otolaryngology community has significant concerns regarding the spread of SARS‐CoV‐2 through droplet contamination and viral aerosolization during head and neck examinations and procedures. The objective of this study was to …
View article: Cadaveric Simulation of Endoscopic Endonasal Procedures: Analysis of Droplet Splatter Patterns During the COVID‐19 Pandemic
Cadaveric Simulation of Endoscopic Endonasal Procedures: Analysis of Droplet Splatter Patterns During the COVID‐19 Pandemic Open
Objective The primary mode of viral transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is thought to occur through the spread of respiratory droplets. The objective of this study was to investigate droplet and spl…
View article: Correlations of Online Search Engine Trends With Coronavirus Disease (COVID-19) Incidence: Infodemiology Study
Correlations of Online Search Engine Trends With Coronavirus Disease (COVID-19) Incidence: Infodemiology Study Open
Background The coronavirus disease (COVID-19) is the latest pandemic of the digital age. With the internet harvesting large amounts of data from the general population in real time, public databases such as Google Trends (GT) and the Baidu…
View article: Correlations of Online Search Engine Trends With Coronavirus Disease (COVID-19) Incidence: Infodemiology Study (Preprint)
Correlations of Online Search Engine Trends With Coronavirus Disease (COVID-19) Incidence: Infodemiology Study (Preprint) Open
BACKGROUND The coronavirus disease (COVID-19) is the latest pandemic of the digital age. With the internet harvesting large amounts of data from the general population in real time, public databases such as Google Trends (GT) and the Baid…
View article: Socioeconomic status and outcomes after sport-related concussion: a preliminary investigation
Socioeconomic status and outcomes after sport-related concussion: a preliminary investigation Open
OBJECTIVE A significant proportion of patients experience long-term symptoms after sport-related concussion (SRC), and several factors have been associated with this protracted recovery. Limited data exist on the role of socioeconomic stat…
View article: Outcomes in transcranial microsurgery versus extended endoscopic endonasal approach for primary resection of adult craniopharyngiomas
Outcomes in transcranial microsurgery versus extended endoscopic endonasal approach for primary resection of adult craniopharyngiomas Open
OBJECTIVE Craniopharyngiomas have historically been resected via transcranial microsurgery (TCM). In the last 2 decades, the extended endoscopic endonasal (transtuberculum) approach to these tumors has become more widely accepted, yet ther…