Kongjia Luo
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View article: The INSPECTOR study: enhanced feasibility for clinical translation of a multi‐cancer early detection method based on enzyme‐assisted high signal‐to‐noise ratio sequencing of methylated circulating tumor DNA
The INSPECTOR study: enhanced feasibility for clinical translation of a multi‐cancer early detection method based on enzyme‐assisted high signal‐to‐noise ratio sequencing of methylated circulating tumor DNA Open
Background Blood‐based cell‐free DNA (cfDNA) methylation testing has emerged as a promising approach for multi‐cancer early detection (MCED), holding the potential to improve cancer survival rates. However, traditional bisulfite‐based meth…
View article: Correction: Impact of lymph node dissection on survival after neoadjuvant immunochemotherapy for esophageal squamous cell cancer: a double-center real-world retrospective study
Correction: Impact of lymph node dissection on survival after neoadjuvant immunochemotherapy for esophageal squamous cell cancer: a double-center real-world retrospective study Open
View article: Pan-immune-inflammation value predicts survival of patients with oesophageal squamous cell carcinoma receiving immunotherapy and chemoradiotherapy: a pooled analysis of two phase II trials
Pan-immune-inflammation value predicts survival of patients with oesophageal squamous cell carcinoma receiving immunotherapy and chemoradiotherapy: a pooled analysis of two phase II trials Open
High PIV zenith during CRT strongly predicts poorer survival outcomes in patients with ESCC treated with combined immunotherapy and CRT. These peaks are associated with higher MLD, reduced interferon α response, interferon γ response and i…
View article: Adjuvant immunotherapy fails to improve survival in ypStage I esophageal cancer after neoadjuvant immunochemotherapy
Adjuvant immunotherapy fails to improve survival in ypStage I esophageal cancer after neoadjuvant immunochemotherapy Open
View article: Circulating tumor DNA as a marker of molecular residual disease in resected esophageal squamous cell carcinoma
Circulating tumor DNA as a marker of molecular residual disease in resected esophageal squamous cell carcinoma Open
View article: Impact of lymph node dissection on survival after neoadjuvant immunochemotherapy for esophageal squamous cell cancer: a double-center real-world retrospective study
Impact of lymph node dissection on survival after neoadjuvant immunochemotherapy for esophageal squamous cell cancer: a double-center real-world retrospective study Open
ypN status is a more powerful prognostic factor than ypT status in ESCC patients treated with NICT and surgery. LND exceeding 48 nodes is associated with diminished survival. An optimal LND range of 32 to 48 nodes is recommended to balance…
View article: Real-world applications of postneoadjuvant stage I of the staging system for oesophageal squamous cell cancer: what is beyond a pathological complete response?
Real-world applications of postneoadjuvant stage I of the staging system for oesophageal squamous cell cancer: what is beyond a pathological complete response? Open
OBJECTIVES The 8th edition of the American Joint Committee on Cancer classification system defines the postneoadjuvant pathological T0-2N0M0 (ypT0-2N0M0) stage as ypI for oesophageal cancer. This study was designed to explore the possible …
View article: Immune checkpoint inhibitors and myocarditis in advanced non-small cell lung cancer: a nationwide cohort study
Immune checkpoint inhibitors and myocarditis in advanced non-small cell lung cancer: a nationwide cohort study Open
View article: Immune checkpoint inhibitors and myocarditis in advanced non-small cell lung cancer: a nationwide cohort study
Immune checkpoint inhibitors and myocarditis in advanced non-small cell lung cancer: a nationwide cohort study Open
Background: Emerging evidence suggests immune checkpoint inhibitor (ICI) therapies can increase the risk of myocarditis —a life-threatening rare adverse event. High quality population-level evidence on the association remains lacking. We i…
View article: Identification of a immune-related genes signature for survival prediction in stage I lung adenocarcinoma
Identification of a immune-related genes signature for survival prediction in stage I lung adenocarcinoma Open
Background With the popularization of low-dose spiral computed tomography (CT), an increasing number of stage I lung cancers have been discovered. Although most of the patients with stage I lung adenocarcinoma have a favorable prognosis, s…
View article: Establishment and validation of a clinicopathological prediction model for postoperative recurrence of stage IA lung adenocarcinoma
Establishment and validation of a clinicopathological prediction model for postoperative recurrence of stage IA lung adenocarcinoma Open
A nomogram model was established that can be beneficial to evaluate RFS in patients with stage IA lung adenocarcinoma after curative resection. It can be of value in helping clinicians develop treatment strategies to improve patient surviv…
View article: Evolution of genome and immunogenome in esophageal squamous cell carcinomas driven by neoadjuvant chemoradiotherapy
Evolution of genome and immunogenome in esophageal squamous cell carcinomas driven by neoadjuvant chemoradiotherapy Open
Background Neoadjuvant chemoradiotherapy (NCRT) followed by surgery is a standard treatment for locally advanced esophageal squamous cell carcinomas (ESCCs). However, evolution of genome and immunogenome in ESCCs driven by NCRT remain inco…
View article: Diagnostic yield using electromagnetic navigation bronchoscopy for peripheral pulmonary nodules <2 cm
Diagnostic yield using electromagnetic navigation bronchoscopy for peripheral pulmonary nodules <2 cm Open
Background: Although electromagnetic navigation bronchoscopy (ENB) is highly sensitive in the diagnosis of peripheral pulmonary nodules (PPNs), its diagnostic yield for subgroups of smaller PPNs is under evaluation. Objectives: Diagnostic …
View article: Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma
Impacts of neoadjuvant chemoradiotherapy on the immune landscape of esophageal squamous cell carcinoma Open
View article: LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription
LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription Open
View article: Temporal Pattern of Cardiac Adverse Events Associated with EGFR-TKIs in Lung Cancer Patients: A Pharmacovigilance Analysis
Temporal Pattern of Cardiac Adverse Events Associated with EGFR-TKIs in Lung Cancer Patients: A Pharmacovigilance Analysis Open
View article: An Approach to Accelerate Healing and Shorten the Hospital Stay of Patients With Anastomotic Leakage After Esophagectomy: An Explorative Study of Systematic Endoscopic Intervention
An Approach to Accelerate Healing and Shorten the Hospital Stay of Patients With Anastomotic Leakage After Esophagectomy: An Explorative Study of Systematic Endoscopic Intervention Open
Objective To explore the comprehensive role of systemic endoscopic intervention in healing esophageal anastomotic leak. Methods In total, 3919 consecutive patients with esophageal cancer who underwent esophagectomy and immediate esophageal…
View article: Endoscopic resection with adjuvant treatment versus esophagectomy for early-stage esophageal cancer
Endoscopic resection with adjuvant treatment versus esophagectomy for early-stage esophageal cancer Open
View article: Low GSTM3 expression is associated with poor disease‐free survival in resected esophageal squamous cell carcinoma
Low GSTM3 expression is associated with poor disease‐free survival in resected esophageal squamous cell carcinoma Open
View article: Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients
Prognostic Role of ABO Blood Type in Operable Esophageal Cancer: Analysis of 2179 Southern Chinese Patients Open
Background The prognostic value of ABO blood types is not well clarified for esophageal carcinoma (EC). This study attempted to elucidate the associations between different ABO blood types and disease-free survival (DFS) and overall surviv…
View article: [Feasibility of injecting Fluorescent Agent under the Guidance of Electromagnetic Navigation Bronchoscopy in Pulmonary Nodule Resection].
[Feasibility of injecting Fluorescent Agent under the Guidance of Electromagnetic Navigation Bronchoscopy in Pulmonary Nodule Resection]. Open
Indocyanine green injection under the guidance of magnetic navigation bronchoscope is an effective way to locate pulmonary nodules, which can locate small and untouchable lesions in the lung. This method can help surgeons identify lesions …
View article: Fibrin sealant for esophageal anastomosis: A phase II study
Fibrin sealant for esophageal anastomosis: A phase II study Open
Perioperative sealing with porcine FS appears safe and may prevent AL after esophagectomy in patients with resectable EC or EJC. Further phase III studies are warranted.
View article: Preoperative weight loss is associated with poorer prognosis in operable esophageal cancer patients: A single-center retrospective analysis of a large cohort of Chinese patients
Preoperative weight loss is associated with poorer prognosis in operable esophageal cancer patients: A single-center retrospective analysis of a large cohort of Chinese patients Open
Background: Preoperative weight loss has been shown to be a prognostic factor for many cancers. However, whether preoperative weight loss has clinical significance in patients with esophageal cancer is still controversial. Method…
View article: Role of Porcine Fibrin Sealant in the Prevention of Cervical Anastomotic Leakage After Esophagectomy for Esophageal or Esophagogastric Junction Cancer (PLACE020): A Phase 2, Single-Arm, Prospective Study
Role of Porcine Fibrin Sealant in the Prevention of Cervical Anastomotic Leakage After Esophagectomy for Esophageal or Esophagogastric Junction Cancer (PLACE020): A Phase 2, Single-Arm, Prospective Study Open
View article: Histone deacetylase 6 expression in metastatic lymph nodes is a valuable prognostic marker for resected node-positive esophageal squamous cell cancer
Histone deacetylase 6 expression in metastatic lymph nodes is a valuable prognostic marker for resected node-positive esophageal squamous cell cancer Open
High expression of HDAC6 in MLNs but not in PTs suggests a poor prognosis for patients with resected T3N1-3M0 ESCC. We should take into account the protein expression of MLNs when assessing prognosis in patients with lymph-node involvement.
View article: miR-424 coordinates multilayered regulation of cell cycle progression to promote esophageal squamous cell carcinoma cell proliferation
miR-424 coordinates multilayered regulation of cell cycle progression to promote esophageal squamous cell carcinoma cell proliferation Open
miR-424 coordinates a previously unknown, multilayered regulation of ESCC cell cycle progression to promote ESCC proliferation, and may be used as a novel prognostic marker and an effective therapeutic target for ESCCs. FUND: National Natu…
View article: Clinical predictors of pathologically response after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma: long term outcomes of a phase II study
Clinical predictors of pathologically response after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma: long term outcomes of a phase II study Open
Our study indicated that good tumor grade were an independent significant factor for the GR to NCRT. Weight loss, drinking status and GR were independent factors in patients with radical esophagectomy after NCRT. GR may improve OS of ESCC …
View article: Strong expression of Id-1 in metastatic lymph nodes from esophageal squamous cell carcinoma is associated with better clinical outcome
Strong expression of Id-1 in metastatic lymph nodes from esophageal squamous cell carcinoma is associated with better clinical outcome Open
The level of Id-1 protein expression was down-regulated from PT to metastatic lymph node. It was contrary to previous studies that strong expression of Id-1 in metastatic lymph nodes was associated with better clinical outcomes in patients…
View article: miR-424 Coordinates Multilayered Regulation of Cell Cycle Progression to Promote Esophageal Squamous Cell Carcinoma Cell Proliferation
miR-424 Coordinates Multilayered Regulation of Cell Cycle Progression to Promote Esophageal Squamous Cell Carcinoma Cell Proliferation Open
View article: P-183LONG-TERM AND SURGICAL OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION VERSUS MINIMALLY INVASIVE OESOPHAGECTOMY FOR SUPERFICIAL OESOPHAGEAL SQUAMOUS CELL CARCINOMA
P-183LONG-TERM AND SURGICAL OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION VERSUS MINIMALLY INVASIVE OESOPHAGECTOMY FOR SUPERFICIAL OESOPHAGEAL SQUAMOUS CELL CARCINOMA Open
group (P=0.065).The overall 3-year survival rate was 89.68% (94.7% in pN0 group, 74.2% in pN+ group).The recurrence rate was 15.8% and the median time interval of recurrence was 23 months.More recurrence happened in the upper mediastinal-n…