Explanipedia

3S-DB identifies an RNA repository facilitating stop codon readthrough for selenocysteine insertion and selenoproteome expansion Open

Chenfang Si, Lu Zhang, Jing Gao, Kongyan Niu, Yunxia Li , et al. · 2025

CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma Open

Yang Wu, Siying Wang, Shuyi Ji, Jian Wang, Shuo Lian , et al. · 2025

Cholangiocarcinoma (CCA) remains a lethal malignancy with limited therapeutic options. Through genome-wide CRISPR-Cas9 screening, we identified the adenosine triphosphatase (ATPase) valosin-containing protein (VCP) as a critical dependency…

Hidden features of NAD-RNA epitranscriptome in Drosophila life cycle Open

Shuwen Ge, Xueting Wang, Yingqin Wang, Dong Minghui, Dean Li , et al. · 2023

Nicotinamide adenine dinucleotide (NAD), a nucleotide-containing metabolite, can be incorporated into the RNA 5'-terminus to result in NAD-capped RNA (NAD-RNA). Since NAD has been heightened as one of the most essential metabolites in cell…

Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization and prediction of chronological age Open

Dean Li, Shuwen Ge, Yandong Liu, Miaomiao Pan, Xueting Wang , et al. · 2023

Nicotinamide adenine dinucleotide (NAD) can be used as an initiating nucleotide in RNA transcription to produce NAD-capped RNA (NAD-RNA). RNA modification by NAD that links metabolite with expressed transcript is a poorly studied epitransc…

Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization Open

Dean Li, Shuwen Ge, Yandong Liu, Miaomiao Pan, Xueting Wang , et al. · 2023

The hub metabolite, nicotinamide adenine dinucleotide (NAD), can be used as an initiating nucleotide in RNA transcription to result in NAD-capped RNA (NAD-RNA). NAD-RNA that intimately connects metabolite with gene expression can be develo…

Single‐Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell–Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice Open

Yang Wu, Hao He, Tongtong Wang, Nan Su, Feng Zhang , et al. · 2021

Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐producing myofibroblasts during liver fibrosis, depending on different etiologies. However, the mechanisms by which their dynamic gene expression direc…

Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma Open

Shuixia Tan, Jing Zhao, Ziyu Sun, Shuangyi Cao, Kongyan Niu , et al. · 2020

Transforming growth factor β-activated kinase1 (TAK1) encoded by the gene MAP3K7 regulates multiple important downstream effectors involved in immune response, cell death, and carcinogenesis. Hepatocyte-specific deletion of TAK1 in Tak1 ΔH…

Author response: Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila Open

Zaijun Ma, Hui Wang, Yuping Cai, Han Wang, Kongyan Niu , et al. · 2018

Epigenetic Drift of H3K27me3 in Aging Links Glycolysis to Healthy Longevity Open

Zaijun Ma, Hui Wang, Yuping Cai, Han Wang, Kongyan Niu , et al. · 2018

Epigenetic alteration has been implicated in aging. However, the mechanism by which epigenetic change impacts aging is unclear. H3K27me3, a highly conserved histone modification signifying transcriptional repression, is marked and maintain…

Quantitative ChIP-seq by Adding Spike-in from Another Species Open

Kongyan Niu, Rui Liu, Nan Liu · 2018

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a routine procedure in the lab; however, epigenome-wide quantitative comparison among independent ChIP-seq experiments remains a challenge. Here, we contribute an experimen…

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