Konomi Kobayashi
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View article: High Serum TSLP Is Characteristic of Late‐Onset, Long‐Duration, Eosinophilic Asthma
High Serum TSLP Is Characteristic of Late‐Onset, Long‐Duration, Eosinophilic Asthma Open
Background Thymic stromal lymphopoietin (TSLP) is a master regulator of type 2 immune responses; however, the associations between serum TSLP and the characteristics of adult asthma have not been fully clarified. The aim of this study was …
View article: Endoscopist’s Satisfaction with the Insertion Phase of Colonoscopy Is a Potential Quality Indicator for Colorectal Polyp Detection: A Propensity Score Matching Study
Endoscopist’s Satisfaction with the Insertion Phase of Colonoscopy Is a Potential Quality Indicator for Colorectal Polyp Detection: A Propensity Score Matching Study Open
Quality indicators during the insertion phase of colonoscopy require exploration. Unsatisfactory insertion experiences cause endoscopist psychophysiological fatigue and affect the quality of their inspection. This comparative study used pr…
View article: Clinical remission of mild-to-moderate asthma: Rates, contributing factors, and stability
Clinical remission of mild-to-moderate asthma: Rates, contributing factors, and stability Open
View article: Real-world effectiveness of mepolizumab in Japanese asthma patients with diverse backgrounds: Improvements in rhinosinusitis imaging (J-Real-Mepo)
Real-world effectiveness of mepolizumab in Japanese asthma patients with diverse backgrounds: Improvements in rhinosinusitis imaging (J-Real-Mepo) Open
View article: Advantage of spirometry over oscillometry to detect dupilumab's effect on small airway dysfunction
Advantage of spirometry over oscillometry to detect dupilumab's effect on small airway dysfunction Open
View article: Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma
Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma Open
Type-2 biomarkers may act as indicators of improvement in FEV1 and sputum outcomes among patients with severe asthma undergoing dupilumab treatment in real-world settings.
View article: Cost‐effective endoscopic screening for gastric cancer in a cohort with low <scp><i>Helicobacter pylori</i></scp> prevalence
Cost‐effective endoscopic screening for gastric cancer in a cohort with low <span><i>Helicobacter pylori</i></span> prevalence Open
Background and Aim Periodic endoscopic screening for gastric cancer (GC) is widely performed in East Asia; however, the optimal screening strategy remains unclear. This study aimed to determine the most cost‐effective endoscopic screening …
View article: Dietary restriction after cold snare polypectomy of colorectal polyp for prevention of delayed bleeding
Dietary restriction after cold snare polypectomy of colorectal polyp for prevention of delayed bleeding Open
Background and Aim Cold snare polypectomy (CSP) for small colorectal polyps is a safe technique; however, there is little evidence on whether dietary restriction after CSP is essential. This study aimed to determine whether dietary restric…
View article: Correlation of toxicities and efficacies of pemetrexed with clinical factors and single-nucleotide polymorphisms: a prospective observational study
Correlation of toxicities and efficacies of pemetrexed with clinical factors and single-nucleotide polymorphisms: a prospective observational study Open
Background Pemetrexed is an efficacious multi-targeted antifolate with acceptable toxicity for non-squamous non-small cell lung cancer (non-Sq NSCLC) and malignant pleural mesothelioma. Vitamin B12 and folic acid as premedication can reduc…
View article: A Case of Humidifier Lung Diagnosed by Lymphocyte Stimulation Test and Precipitating Antibody Testing Using Residual Water in Humidifier
A Case of Humidifier Lung Diagnosed by Lymphocyte Stimulation Test and Precipitating Antibody Testing Using Residual Water in Humidifier Open
View article: An algorithm-based active cleansing protocol can reduce the bowel preparation time for screening colonoscopy: A propensity score matching study
An algorithm-based active cleansing protocol can reduce the bowel preparation time for screening colonoscopy: A propensity score matching study Open
Background: Methods that minimize the time for on-site bowel preparation before colonoscopy are needed. We prospectively validated that a novel algorithm-based active cleansing (ABAC) protocol could reduce the time for preparation compared…
View article: Contributing factor for the pirfenidone dose reduction in patients with idiopathic interstitial pneumonia in real-world settings—A dose-specific analysis
Contributing factor for the pirfenidone dose reduction in patients with idiopathic interstitial pneumonia in real-world settings—A dose-specific analysis Open
Background Pirfenidone slows the progression of interstitial lung disease; however, in real-world settings, many patients discontinue or reduce its dosage owing to its adverse events. The contributing factors of low maintenance doses of pi…
View article: Questionnaire for diagnosing asthma-COPD overlap in COPD: Development of ACO screening questionnaire (ACO-Q)
Questionnaire for diagnosing asthma-COPD overlap in COPD: Development of ACO screening questionnaire (ACO-Q) Open
A simple questionnaire, ACO-Q, was developed. Patients with scores ≥3 could be reasonably recommended to be treated as ACO, and additional laboratory testing would be recommended for patients with 1 and 2 points.
View article: Short- and long-term efficacy of bronchial artery embolization using a gelatin sponge for the treatment of cryptogenic hemoptysis
Short- and long-term efficacy of bronchial artery embolization using a gelatin sponge for the treatment of cryptogenic hemoptysis Open
Bronchial artery embolization (BAE) is the first choice treatment for hemoptysis. With advances in endovascular treatment, various embolic materials have become available. However, the optimal embolic material for the treatment of cryptoge…
View article: Treatments of refractory eosinophilic lung diseases with biologics
Treatments of refractory eosinophilic lung diseases with biologics Open
Biologics targeting the molecules associated with type 2 inflammation have significantly improved the outcomes of patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Chronic eosinophilic airway/l…
View article: Quality management system for screening esophagogastroduodenoscopy improves detection of Helicobacter pylori-negative interval gastric cancer
Quality management system for screening esophagogastroduodenoscopy improves detection of Helicobacter pylori-negative interval gastric cancer Open
Background and study aims Double-checking the findings of examinations is necessary for endoscopy quality control in gastric cancer screening; however, there have been no reports showing its effectiveness. We prospectively analyzed the eff…
View article: Quality management system for screening esophagogastroduodenoscopy improves detection of Helicobacter pylori-negative interval gastric cancer
Quality management system for screening esophagogastroduodenoscopy improves detection of Helicobacter pylori-negative interval gastric cancer Open
[This corrects the article DOI: 10.1055/a-1594-1833.].
View article: Mepolizumab decreased the levels of serum galectin-10 and eosinophil cationic protein in asthma
Mepolizumab decreased the levels of serum galectin-10 and eosinophil cationic protein in asthma Open
Background Mepolizumab, a humanized antibody targeting interleukin-5, decreases the number of blood eosinophils and the frequency of exacerbation of severe asthma. Galectin-10 is a protein within the cytoplasm of eosinophils and constitute…
View article: Comprehensive analysis of allergen-specific IgE in COPD: mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap
Comprehensive analysis of allergen-specific IgE in COPD: mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap Open
View article: Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap
Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap Open
Background: Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen has a significant effect on COPD pathology is unclea…
View article: Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap
Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap Open
Background Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen has a significant effect on COPD pathology is unclear…
View article: The relationship between withdrawal time and adenoma detection rate in a screening colonoscopy for medical check-up
The relationship between withdrawal time and adenoma detection rate in a screening colonoscopy for medical check-up Open
Objective: The purpose of this study was to determine the relationship between withdrawal time (WT) and quality indicators (Polyp Detection Rate (PDR), Adenomatous polyp Detection Rate (ADR), Mean number of Polyps found per Patient (MPP), …
View article: Quality Indicators for the Detection of Helicobacter pylori-Negative Early Gastric Cancer: A Retrospective Observational Study
Quality Indicators for the Detection of Helicobacter pylori-Negative Early Gastric Cancer: A Retrospective Observational Study Open
While observation time during screening endoscopy was a quality indicator for detecting HRLs in HP-eradicated patients, experience of endoscopy was a quality indicator for detecting HRLs in HP-naïve patients.
View article: Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study
Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study Open
View article: A case of recurrent hemoptysis caused by pulmonary actinomycosis diagnosed using transbronchial lung biopsy after bronchial artery embolism and a brief review of the literature
A case of recurrent hemoptysis caused by pulmonary actinomycosis diagnosed using transbronchial lung biopsy after bronchial artery embolism and a brief review of the literature Open
A 60-year-old man was admitted to our hospital because of massive hemoptysis with acute respiratory failure. Since six months ago, he noticed gradual worsening of hemoptysis and was transferred to our hospital. Chest computed tomography sh…
View article: Influence of<i>Helicobacter pylori</i>Infection on Endoscopic Findings of Gastric Adenocarcinoma of the Fundic Gland Type
Influence of<i>Helicobacter pylori</i>Infection on Endoscopic Findings of Gastric Adenocarcinoma of the Fundic Gland Type Open
The change in background mucosa due to HP infection influenced the thickness of the covering layer over the tumor ducts and M-NBI finding of GA-FG-CCP.
View article: Effectiveness of clarithromycin in patients with yellow nail syndrome
Effectiveness of clarithromycin in patients with yellow nail syndrome Open
Ethical approval was provided by the institutional review board of the National Center of Global Health and Medicine (NCGM-G-002143-00), in January 2017. This study is retrospectively registered for UMIN Clinical Trial Registry ( UMIN00002…
View article: A case of pulmonary cyst and pneumothorax after bronchial thermoplasty
A case of pulmonary cyst and pneumothorax after bronchial thermoplasty Open
Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma using thermal energy to reduce smooth muscle in the bronchial wall. A 47‐year‐old man underwent BT for uncontrolled severe asthma despite maximal pharmacological tr…
View article: Massive Hemoptysis with a Fungus Ball-like Shadow in an Old Tuberculosis Cavity That Was Shown to Be a Clot by Bronchoscopy
Massive Hemoptysis with a Fungus Ball-like Shadow in an Old Tuberculosis Cavity That Was Shown to Be a Clot by Bronchoscopy Open
Development of aspergilloma is common in cases with a fungus ball-like shadow in cavities due to old tuberculosis. Some reports have shown that blood clots tend to appear as a fungus ball-like shadow. A 71-year-old man with a history of pu…
View article: Bronchial thermoplasty for severe uncontrolled asthma in Japan
Bronchial thermoplasty for severe uncontrolled asthma in Japan Open