Anne Eugster
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View article: IGLV3-21<sup>R110</sup>-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia
IGLV3-21<sup>R110</sup>-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia Open
We previously used a disease-specific B cell receptor (BCR) point mutation (IGLV3-21R110) for selective targeting of a high-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells. Since CLL is a dise…
View article: Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis
Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis Open
Epigenetic mechanisms regulate gene expression programs during neurogenesis, but the extent of epigenetic remodeling during human cortical development remains unknown. Here, we characterize the epigenetic landscape of the human developing …
View article: Functional Dichotomy of Developmental Foxp3<sup>+</sup>Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice
Functional Dichotomy of Developmental Foxp3<sup>+</sup>Treg Cell Subsets in the Visceral Adipose Tissue of Lean and Obese Mice Open
SUMMARY Chronic inflammation and loss of Foxp3 + regulatory T (Treg) cells in the visceral adipose tissue (VAT) are hallmarks of the pathogenesis of insulin resistance and obesity. This study explores the roles of VAT Treg cells from thymi…
View article: Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes
Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes Open
Autoimmune diseases result from autoantigen-mediated activation of adaptive immunity; intriguingly, autoantigen-specific T cells are also present in healthy donors. An assessment of dynamic changes of this autoreactive repertoire in both h…
View article: Gene expression profiles in placenta and their association with anesthesia, delivery mode and maternal diabetes
Gene expression profiles in placenta and their association with anesthesia, delivery mode and maternal diabetes Open
The findings reveal suppression of immune pathways and upregulation of ribosome activity in the placenta by maternal diabetes highlighting the importance of confounding factors when examining cell and tissue expression profiles. Further st…
View article: Epigenome profiling identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis
Epigenome profiling identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis Open
Summary Epigenetic mechanisms regulate gene expression programs during neurogenesis, but the extent of epigenetic remodelling during human cortical development remains unknown. Here, we characterize the epigenetic landscape of the human de…
View article: Lessons learned from the IMMREP23 TCR-epitope prediction challenge
Lessons learned from the IMMREP23 TCR-epitope prediction challenge Open
International audience
View article: Small RNA-Seq and real time rt-qPCR reveal islet miRNA released under stress conditions
Small RNA-Seq and real time rt-qPCR reveal islet miRNA released under stress conditions Open
Replacement of beta cells through transplantation is a potential therapeutic approach for individuals with pancreas removal or poorly controllable type 1 diabetes. However, stress and death of beta cells pose significant challenges. Circul…
View article: SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood Open
Importance The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etio…
View article: Benchmarking solutions to the T-cell receptor epitope prediction problem: IMMREP22 workshop report
Benchmarking solutions to the T-cell receptor epitope prediction problem: IMMREP22 workshop report Open
Many different solutions to predicting the cognate epitope target of a T-cell receptor (TCR) have been proposed. However several questions on the advantages and disadvantages of these different approaches remain unresolved, as most methods…
View article: Corrigendum: A novel type I interferon primed dendritic cell subpopulation in TREX1 mutant chilblain lupus patients
Corrigendum: A novel type I interferon primed dendritic cell subpopulation in TREX1 mutant chilblain lupus patients Open
[This corrects the article DOI: 10.3389/fimmu.2022.897500.].
View article: Benchmarking solutions to the T-cell receptor epitope prediction problem: IMMREP22 workshop report
Benchmarking solutions to the T-cell receptor epitope prediction problem: IMMREP22 workshop report Open
Many different solutions to predicting the cognate epitope target of a T-cell receptor (TCR) have been proposed. However several questions on the advantages and disadvantages of these different approaches remain unresolved, as most methods…
View article: A Novel Type I Interferon Primed Dendritic Cell Subpopulation in TREX1 Mutant Chilblain Lupus Patients
A Novel Type I Interferon Primed Dendritic Cell Subpopulation in TREX1 Mutant Chilblain Lupus Patients Open
Heterozygous TREX1 mutations are associated with monogenic familial chilblain lupus and represent a risk factor for developing systemic lupus erythematosus. These interferonopathies originate from chronic type I interferon stimulation due …
View article: Autoantibodies against <scp>ATP4A</scp> are a feature of the abundant autoimmunity that develops in first‐degree relatives of patients with type 1 diabetes
Autoantibodies against <span>ATP4A</span> are a feature of the abundant autoimmunity that develops in first‐degree relatives of patients with type 1 diabetes Open
Relatives of patients with type 1 diabetes who have risk genotypes are at very high risk for the development of autoimmunity against gastric and other organs.
View article: Distinguishing activated T regulatory cell and T conventional cells by single‐cell technologies
Distinguishing activated T regulatory cell and T conventional cells by single‐cell technologies Open
Resting conventional T cells (Tconv) can be distinguished from T regulatory cells (Treg) by the canonical markers FOXP3, CD25 and CD127. However, the expression of these proteins alters after T‐cell activation leading to overlap between Tc…
View article: Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme
Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme Open
Significance During infection, extracellular “labile” heme, released from damaged red blood or parenchymal cells, acts as prototypical alarmin stimulating myeloid cells. A characteristic hallmark of myeloid cell activation is the developme…
View article: Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling
Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling Open
Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become widespread, providing new insights into the immune system with potential broad clinical and diagnostic applications. However, like many high-throughput technologie…
View article: The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease
The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease Open
Currently, we are experiencing a true pandemic of a communicable disease by the virus SARS-CoV-2 holding the whole world firmly in its grasp. Amazingly and unfortunately, this virus uses a metabolic and endocrine pathway via ACE2 to enter …
View article: Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling
Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling Open
Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become widespread, providing new insights into the immune system with potential broad clinical and diagnostic applications. However, like many high-throughput technologie…
View article: Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomized trial
Oral insulin immunotherapy in children at risk for type 1 diabetes in a randomized trial Open
Background Oral administration of antigen can induce immunological tolerance. Insulin is a key autoantigen in childhood type 1 diabetes with insulin autoimmunity often appearing in the first years of life. Here, oral insulin was given as a…
View article: Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4+ T Cells in Offspring
Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4+ T Cells in Offspring Open
Autoimmunity against pancreatic β-cell autoantigens is a characteristic of childhood type 1 diabetes (T1D). Autoimmunity usually appears in genetically susceptible children with the development of autoantibodies against (pro)insulin in ear…
View article: Heme induces innate immune memory
Heme induces innate immune memory Open
Trained immunity defines long-lasting adaptive responses of innate immunity, mediated by transcriptional and epigenetic modifications of myeloid cells. Here, we report that labile heme, an alarmin released extracellularily upon tissue dama…
View article: Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level
Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level Open
CD8+ T cells are important effectors of adaptive immunity against pathogens, tumors, and self antigens. Here, we asked how human cognate antigen-responsive CD8+ T cells and their receptors could be identified in unselected single-cell gene…