Klaus Scheffler
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View article: High‐resolution deuterium metabolic imaging of the human brain at 9.4 T using phase‐cycled <scp>balanced SSFP</scp> spectral–spatial acquisitions
High‐resolution deuterium metabolic imaging of the human brain at 9.4 T using phase‐cycled <span>balanced SSFP</span> spectral–spatial acquisitions Open
Purpose The aim was to improve the sensitivity and robustness against B 0 inhomogeneities of deuterium metabolic imaging (DMI) using phase‐cycled balanced SSFP (bSSFP) methods at 9.4 T. Methods We investigated two variants of phase‐cycled …
View article: Direct encoding of new visual concepts in early visual cortex
Direct encoding of new visual concepts in early visual cortex Open
Neocortical memories are assumed to rely on slow systems consolidation through hippocampal offline reactivation. However, recent studies show rapid neocortical integration of new memories for information associated with prior knowledge. Te…
View article: Improved efficiency of the new Mirus™ system challenged by ventilatory settings—a bench study
Improved efficiency of the new Mirus™ system challenged by ventilatory settings—a bench study Open
The Mirus™ system (Technologie Institut Medizin GmbH, Germany) enables target-controlled delivery of volatile anaesthetics with open system ventilators. Its interface, positioned between Y-piece and the patient, injects anaesthetic vapor d…
View article: SMAS: Structural MRI-based AD Score using Bayesian supervised VAE
SMAS: Structural MRI-based AD Score using Bayesian supervised VAE Open
This study introduces the Structural MRI-based Alzheimer's Disease Score (SMAS), a novel index intended to quantify Alzheimer's Disease (AD)-related morphometric patterns using a deep learning Bayesian-supervised Variational Autoencoder (B…
View article: Polar Fourier transform in practice: its efficiency and characteristics in reconstructing radially acquired MRI images
Polar Fourier transform in practice: its efficiency and characteristics in reconstructing radially acquired MRI images Open
Objective The Polar Fourier Transform (PFT) has been proposed as a direct alternative to gridding for reconstructing radially acquired MRI data. This study evaluates the feasibility of inline PFT implementation on a clinical MRI scanner an…
View article: Indirect Zero-Field Nuclear Magnetic Resonance Spectroscopy
Indirect Zero-Field Nuclear Magnetic Resonance Spectroscopy Open
This study develops the two-field correlation spectroscopy (COSY) in zero to ultralow field (ZULF) liquid state nuclear magnetic resonance (NMR). We demonstrated the successful integration of signal amplification by reversible exchange (SA…
View article: Disease stage–specific atrophy markers in Alzheimer's disease
Disease stage–specific atrophy markers in Alzheimer's disease Open
INTRODUCTION Structural magnetic resonance imaging (MRI) often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal atrop…
View article: Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance
Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance Open
Introduction We studied brain maintenance, examining the co-evolution of ageing-related atrophy, white matter hyperintensities (WMH), and cognition, alongside domain-specific and domain-general contributions of lifestyle and personality. M…
View article: <scp>Mini social cognition</scp> and <scp>emotional assessment</scp> : <scp>Diagnostic performance</scp> and <scp>neural correlates</scp> in behavioural‐variant <scp>frontotemporal dementia</scp>
<span>Mini social cognition</span> and <span>emotional assessment</span> : <span>Diagnostic performance</span> and <span>neural correlates</span> in behavioural‐variant <span>frontotemporal dementia</span> Open
We aimed at validating the Mini Social Cognition and Emotional Assessment (Mini‐SEA) in a German cohort of mildly impaired behavioural‐variant frontotemporal dementia (bvFTD) patients and healthy controls. The Mini‐SEA comprises the Facial…
View article: Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease
Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is characterised by the accumulation of beta-amyloid (Aβ) and tau proteins, leading to neurodegeneration and cognitive decline. While Aβ and tau are known to disrupt synaptic function, the mechanisms linking these …
View article: An Unsupervised XAI Framework for Dementia Detection with Context Enrichment
An Unsupervised XAI Framework for Dementia Detection with Context Enrichment Open
Introduction Explainable Artificial Intelligence (XAI) methods enhance the diagnostic efficiency of clinical decision support systems by making the predictions of a convolutional neural network’s (CNN) on brain imaging more transparent and…
View article: Correction: Easy scalable, low-cost open-source magnetic field detection system for evaluating low-field MRI magnets using a motion-tracked robot
Correction: Easy scalable, low-cost open-source magnetic field detection system for evaluating low-field MRI magnets using a motion-tracked robot Open
View article: Functional connectivity of thalamic nuclei during sensorimotor task-based fMRI at 9.4 Tesla
Functional connectivity of thalamic nuclei during sensorimotor task-based fMRI at 9.4 Tesla Open
The thalamus is the brain’s central communication hub, playing a key role in processing and relaying sensorimotor and cognitive information between the cerebral cortex and other brain regions. It consists of specific and non-specific nucle…
View article: Fiber architecture in the human ventromedial striatum and its relation with the bed nucleus of the stria terminalis
Fiber architecture in the human ventromedial striatum and its relation with the bed nucleus of the stria terminalis Open
The bed nucleus of the stria terminalis (BST) and the ventromedial striatum (consisting of the head of the caudate nucleus (hCN) and the nucleus accumbens (NAcc)) are both part of complex, foremost limbic networks involved in a variety of …
View article: Neural processing of laughter in depression
Neural processing of laughter in depression Open
View article: A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans
A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans Open
Background Convolutional neural network (CNN) based volumetry of MRI data can help differentiate Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD) as causes of cognitive decline and dementia. However, e…
View article: Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease Open
Subjective cognitive decline (SCD) is proposed as an indicator of transitional disease stage 2 in the Alzheimer’s disease (AD) continuum. However, molecular and particularly longitudinal fluid biomarker data for this stage are still limite…
View article: Easy scalable, low-cost open-source magnetic field detection system for evaluating low-field MRI magnets using a motion-tracked robot
Easy scalable, low-cost open-source magnetic field detection system for evaluating low-field MRI magnets using a motion-tracked robot Open
View article: Beyond ROIs: Laminar fMRI Mapping with Cylarim
Beyond ROIs: Laminar fMRI Mapping with Cylarim Open
Laminar fMRI offers a powerful approach to investigate brain function by resolving neural activity across the distinct layers of the cortical gray matter. However, current laminar fMRI analysis methods often rely on predefined regions of i…
View article: Disease stage-specific atrophy markers in Alzheimer’s disease
Disease stage-specific atrophy markers in Alzheimer’s disease Open
INTRODUCTION Structural MRI often lacks diagnostic, prognostic, and monitoring value in Alzheimer’s disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal MRI readouts for different use cas…
View article: Flexible and cost-effective deep learning for accelerated multi-parametric relaxometry using phase-cycled bSSFP
Flexible and cost-effective deep learning for accelerated multi-parametric relaxometry using phase-cycled bSSFP Open
To accelerate the clinical adoption of quantitative magnetic resonance imaging (qMRI), frameworks are needed that not only allow for rapid acquisition, but also flexibility, cost efficiency, and high accuracy in parameter mapping. In this …
View article: High-resolution deuterium metabolic imaging of the human brain at 9.4 T using bSSFP spectral-spatial acquisitions
High-resolution deuterium metabolic imaging of the human brain at 9.4 T using bSSFP spectral-spatial acquisitions Open
We demonstrated the feasibility of using bSSFP acquisitions for off-resonance insensitive high-resolution [6,6'-2H2]-glucose deuterium metabolic imaging (DMI) studies in the healthy human brain at 9.4T. Balanced SSFP acquisitions have pote…
View article: CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum
CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum Open
Neurotransmitter systems of noradrenaline, dopamine, serotonin and acetylcholine are implicated in cognitive functions such as memory, learning and attention and are known to be altered in neurodegenerative diseases like Alzheimer’s diseas…
View article: Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults
Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults Open
Background In humans, environmental enrichment (EE), as measured by the engagement in a variety of leisure activities, has been associated with larger hippocampal structure and better memory function. The present cross-sectional study asse…
View article: Indirect Zero Field NMR Spectroscopy
Indirect Zero Field NMR Spectroscopy Open
This study pioneers the two-field correlation spectroscopy (COSY) in zero to ultralow field (ZULF) liquid state NMR, employing hyperpolarized [1-$^{13}$C]pyruvate as a model system. We demonstrate the successful integration of signal ampli…
View article: Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer’s disease
Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer’s disease Open
Hyperphosphorylated tau accumulation is seen in the noradrenergic locus coeruleus from the earliest stages of Alzheimer’s disease onwards and has been associated with symptoms of agitation. It is hypothesized that compensatory locus coerul…
View article: Abnormalities in task‐fMRI activation are related to disease progression towards Alzheimer’s disease
Abnormalities in task‐fMRI activation are related to disease progression towards Alzheimer’s disease Open
Background Differences in task‐fMRI activation have recently been found to be related to neuropathological hallmarks of AD. However, the evolution of fMRI‐based activation throughout AD disease progression and its relationship with other b…
View article: A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting
A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting Open
Background Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’…
View article: A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting
A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting Open
Background Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’…
View article: Abnormalities in task‐fMRI activation are related to disease progression towards Alzheimer’s disease
Abnormalities in task‐fMRI activation are related to disease progression towards Alzheimer’s disease Open
Background Differences in task‐fMRI activation have recently been found to be related to neuropathological hallmarks of AD. However, the evolution of fMRI‐based activation throughout AD disease progression and its relationship with other b…