Konrad Wagstyl
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View article: Thalamocortical structural connectivity in children with focal epilepsy: a diffusion MRI, case-control study
Thalamocortical structural connectivity in children with focal epilepsy: a diffusion MRI, case-control study Open
Objectives Determining patient-specific thalamic connectivity alterations may be an important step towards personalized surgical and neuromodulation strategies, but no data are available to support this concept in pediatric cohorts. This s…
View article: Fractionation of sex differences in human cortical anatomy
Fractionation of sex differences in human cortical anatomy Open
Humans show reproducible sex differences in regional cortical volume (CV), but it remains unclear how these arise from underlying sex-biases in the two biologically dissociable determinants of CV: surface area (SA) and cortical thickness (…
View article: Charting structural brain asymmetry across the human lifespan
Charting structural brain asymmetry across the human lifespan Open
Lateralization is a fundamental principle of structural brain organization. In vivo imaging of brain asymmetry is essential for deciphering lateralized brain functions and their disruption in neurodevelopmental and neurodegenerative disord…
View article: Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia
Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia Open
Human brain organization involves the coordinated expression of thousands of genes. For example, the first principal component (C1) of cortical transcription identifies a hierarchy from sensorimotor to association regions. In this study, o…
View article: Author Response: Transcriptional cartography integrates multiscale biology of the human cortex
Author Response: Transcriptional cartography integrates multiscale biology of the human cortex Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract The cerebral cortex un…
View article: Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex
Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex Open
The cerebral cortex underlies many of our unique strengths and vulnerabilities - but efforts to understand human cortical organization are challenged by reliance on incompatible measurement methods at different spatial scales. Macroscale f…
View article: Author Response: Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex
Author Response: Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex Open
The cerebral cortex underlies many of our unique strengths and vulnerabilities - but efforts to understand human cortical organization are challenged by reliance on incompatible measurement methods at different spatial scales. Macroscale f…
View article: A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients
A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients Open
Summary We developed a computational pipeline (now provided as a resource) for measuring morphological similarity between cortical surface sulci to construct a sulcal phenotype network (SPN) from each magnetic resonance imaging (MRI) scan …
View article: The molecular genetic landscape of human brain size variation
The molecular genetic landscape of human brain size variation Open
View article: Automated and Interpretable Detection of Hippocampal Sclerosis in temporal lobe epilepsy: AID-HS
Automated and Interpretable Detection of Hippocampal Sclerosis in temporal lobe epilepsy: AID-HS Open
Hippocampal Sclerosis (HS) can elude visual detection on MRI scans of patients with temporal lobe epilepsy (TLE), causing delays in surgical treatment and reducing the likelihood of postsurgical seizure-freedom. We developed an open-source…
View article: Pediatric epilepsy surgery from 2000 to 2018: Changes in referral and surgical volumes, patient characteristics, genetic testing, and postsurgical outcomes
Pediatric epilepsy surgery from 2000 to 2018: Changes in referral and surgical volumes, patient characteristics, genetic testing, and postsurgical outcomes Open
Objective Neurosurgery is a safe and effective form of treatment for select children with drug‐resistant epilepsy. Still, there is concern that it remains underutilized, and that seizure freedom rates have not improved over time. We invest…
View article: Robust and Generalisable Segmentation of Subtle Epilepsy-causing Lesions: a Graph Convolutional Approach
Robust and Generalisable Segmentation of Subtle Epilepsy-causing Lesions: a Graph Convolutional Approach Open
Focal cortical dysplasia (FCD) is a leading cause of drug-resistant focal epilepsy, which can be cured by surgery. These lesions are extremely subtle and often missed even by expert neuroradiologists. "Ground truth" manual lesion masks are…
View article: Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex
Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex Open
The cerebral cortex underlies many of our unique strengths and vulnerabilities - but efforts to understand human cortical organization are challenged by reliance on incompatible measurement methods at different spatial scales. Macroscale f…
View article: Author Response: Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex
Author Response: Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex Open
The cerebral cortex underlies many of our unique strengths and vulnerabilities - but efforts to understand human cortical organization are challenged by reliance on incompatible measurement methods at different spatial scales. Macroscale f…
View article: The spatial arrangement of laminar thickness profiles in the human cortex scaffolds processing hierarchy
The spatial arrangement of laminar thickness profiles in the human cortex scaffolds processing hierarchy Open
The human neocortex consists of tangentially organized layers with unique cytoarchitectural properties. These layers show spatial variations in thickness and cytoarchitecture across the neocortex, which is thought to support brain function…
View article: Predicting seizure outcome after epilepsy surgery: do we need more complex models, larger samples, or better data?
Predicting seizure outcome after epilepsy surgery: do we need more complex models, larger samples, or better data? Open
Objective The accurate prediction of seizure freedom after epilepsy surgery remains challenging. We investigated if 1) training more complex models, 2) recruiting larger sample sizes, or 3) using data-driven selection of clinical predictor…
View article: Artificial intelligence for the detection of focal cortical dysplasia: Challenges in translating algorithms into clinical practice
Artificial intelligence for the detection of focal cortical dysplasia: Challenges in translating algorithms into clinical practice Open
Focal cortical dysplasias (FCDs) are malformations of cortical development and one of the most common pathologies causing pharmacoresistant focal epilepsy. Resective neurosurgery yields high success rates, especially if the full extent of …
View article: 3D reconstruction of ultra-high resolution neurotransmitter receptor atlases in human and non-human primate brains
3D reconstruction of ultra-high resolution neurotransmitter receptor atlases in human and non-human primate brains Open
Quantitative maps of neurotransmitter receptor densities are important tools for characterising the molecular organisation of the brain and key for understanding normal and pathologic brain function and behaviour. We describe a novel metho…
View article: Mesoscopic in vivo human <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.svg"> <mml:msubsup> <mml:mtext>T</mml:mtext> <mml:mn>2</mml:mn> <mml:mo>*</mml:mo> </mml:msubsup> </mml:math> dataset acquired using quantitative MRI at 7 Tesla
Mesoscopic in vivo human dataset acquired using quantitative MRI at 7 Tesla Open
View article: The molecular genetic landscape of human brain size variation
The molecular genetic landscape of human brain size variation Open
Human brain size increases dynamically through early development, peaks in adolescence, and varies up to two-fold among adults. Although previous studies have elucidated changes in brain size across evolution, development, traits, and dise…
View article: Three components of human brain gene expression reflect normative developmental programmes with specific links to neurodevelopmental disorders
Three components of human brain gene expression reflect normative developmental programmes with specific links to neurodevelopmental disorders Open
Human brain organisation emerges from the coordinated transcription of thousands of genes, and the first principal component (C1) of spatial whole genome expression was shown to reflect cortical hierarchy. Here, optimised processing of the…
View article: Conserved whole-brain spatiomolecular gradients shape adult brain functional organization
Conserved whole-brain spatiomolecular gradients shape adult brain functional organization Open
Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression of morphogens and transcription factors. However, how these gradients relate to adult brain function, and whe…
View article: Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex
Transcriptional Cartography Integrates Multiscale Biology of the Human Cortex Open
The cerebral cortex underlies many of our unique strengths and vulnerabilities - but efforts to understand human cortical organization are challenged by reliance on incompatible measurement methods at different spatial scales. Macroscale f…
View article: Interpretable surface-based detection of focal cortical dysplasias: a MELD study
Interpretable surface-based detection of focal cortical dysplasias: a MELD study Open
Introduction One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application is the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MR…
View article: Mesoscopic in vivo human T<sub>2</sub>* dataset acquired using quantitative MRI at 7 Tesla
Mesoscopic in vivo human T<sub>2</sub>* dataset acquired using quantitative MRI at 7 Tesla Open
A bstract Mesoscopic (0.1-0.5 mm) interrogation of the living human brain is critical for advancing neuroscience and bridging the resolution gap with animal models. Despite the variety of MRI contrasts measured in recent years at the mesos…
View article: Decision letter: The Digital Brain Bank, an open access platform for post-mortem imaging datasets
Decision letter: The Digital Brain Bank, an open access platform for post-mortem imaging datasets Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Appendix 2 Appendix 3 Appendix 4 Data availability References Decision letter Author response Article and author informa…
View article: The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging
The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging Open
Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is ‘BigBrain’. Here, we review recent methodological advances for the integration of BigBrain with multi-modal…
View article: Author response: The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging
Author response: The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging Open
View article: Cortical patterning of morphometric similarity gradient reveals diverged hierarchical organization in sensory-motor cortices
Cortical patterning of morphometric similarity gradient reveals diverged hierarchical organization in sensory-motor cortices Open
The topological organization of the cerebral cortex provides hierarchical axes, namely gradients, which reveal systematic variations of brain structure and function. However, the hierarchical organization of macroscopic brain morphology an…
View article: Protocol 1: Clinical and demographic information v1
Protocol 1: Clinical and demographic information v1 Open
The MELD Project is an international collaboration aiming to create open-access, robust and generalisable tools for FCD detection. This MRI data protocol details 1) How to get access to the MELD Focal Epilepsies Redcap database 2) Inclusio…