Konstantin Aizikov
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View article: Orbitrap noise structure and method for noise unbiased multivariate analysis
Orbitrap noise structure and method for noise unbiased multivariate analysis Open
Orbitrap mass spectrometry is widely used in the life-sciences. However, like all mass spectrometers, non-uniform (heteroscedastic) noise introduces bias in multivariate analysis complicating data interpretation. Here, we study the noise s…
View article: Enhancing Tandem MS Sensitivity and Peptide Identification via Ion Preaccumulation in an Orbitrap Mass Spectrometer
Enhancing Tandem MS Sensitivity and Peptide Identification via Ion Preaccumulation in an Orbitrap Mass Spectrometer Open
High-throughput mass spectrometry-based proteomics has gained increasing interest for both academic and industrial applications. As implementation of faster gradients has facilitated higher sample throughput, mass spectrometers must adapt …
View article: Orbitrap noise structure and method for noise-unbiased multivariate analysis
Orbitrap noise structure and method for noise-unbiased multivariate analysis Open
Orbitrap mass spectrometry is widely used in the life-sciences. However, like all mass spectrometers, non-uniform (heteroscedastic) noise introduces bias in multivariate analysis complicating data interpretation. Here, we study the noise s…
View article: Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis
Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis Open
View article: Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis
Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis Open
The measurement of collision cross sections (CCS) offers supplemental information about sizes and conformations of ions beyond mass analysis alone. We have previously shown that CCSs can be determined directly from the time-domain transien…
View article: Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays
Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays Open
View article: Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis
Expanding Orbitrap collision cross section measurements to native protein applications through kinetic energy and signal decay analysis Open
The measurement of collision cross sections (CCS) offers supplemental information about sizes and conformations of ions beyond mass analysis alone. We have previously shown that CCSs can be determined directly from the time-domain transien…
View article: Improving the Sensitivity of Fourier Transform Mass Spectrometer (Orbitrap) for Online Measurements of Atmospheric Vapors
Improving the Sensitivity of Fourier Transform Mass Spectrometer (Orbitrap) for Online Measurements of Atmospheric Vapors Open
Orbitrap Fourier transform mass spectrometry coupled with chemical ionization (CI) is a new-generation technique for online analysis in atmospheric chemistry. The advantage of the high resolving power of the CI-Orbitrap has been compromise…
View article: Frequency chasing of individual megadalton ions in an Orbitrap analyser improves precision of analysis in single-molecule mass spectrometry
Frequency chasing of individual megadalton ions in an Orbitrap analyser improves precision of analysis in single-molecule mass spectrometry Open
View article: Frequency chasing of individual megadalton ions in an Orbitrap analyzer improves precision of analysis in single molecule mass spectrometry
Frequency chasing of individual megadalton ions in an Orbitrap analyzer improves precision of analysis in single molecule mass spectrometry Open
To enhance the performance of charge detection mass spectrometry, we investigated the behavior of macromolecular single ions on their paths towards and within the Orbitrap analyzer. We discovered that ions in mass beyond one megadalton rea…
View article: Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody
Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody Open
Pairing light and heavy chains in monoclonal antibodies (mAbs) using top-down (TD) or middle-down (MD) mass spectrometry (MS) may complement the sequence information on single chains provided by high-throughput genomic sequencing and botto…
View article: Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer
Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer Open
We demonstrate a method for determining the collision cross-sections (CCSs) of protein ions based on the decay rate of the time-domain transient signal from an Orbitrap mass analyzer. Multiply charged ions of ubiquitin, cytochrome c, and m…
View article: Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer
Determination of Collision Cross-Sections of Protein Ions in an Orbitrap Mass Analyzer Open
Postprint of publication in Analytical Chemistry 2018: https://pubs.acs.org/doi/10.1021/acs.analchem.8b00724
View article: Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer
Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer Open