Konstantin Doberer
YOU?
Author Swipe
View article: Immune Monitoring Goes Viral – Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation
Immune Monitoring Goes Viral – Torque Teno Virus for Immunologic Risk Stratification After Kidney Transplantation Open
Using biomarkers to tailor immunosuppressive therapy after kidney transplantation was proposed to improve clinical care. Timely and individual adaptions of immunosuppression could reduce therapy-related side effects, such as infections, ca…
View article: Statistical analysis plan for TTVguideIT—a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation
Statistical analysis plan for TTVguideIT—a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation Open
View article: #2402 Torque teno virus is associated with an increased risk for malignancies after kidney transplantation
#2402 Torque teno virus is associated with an increased risk for malignancies after kidney transplantation Open
Background and Aims The risk for malignancies is increased after kidney transplantation due to immunosuppression. Torque teno virus (TTV) is a ubiquitous and non-pathogenic virus which reflects the immunocompetence of its host. TTV load ha…
View article: #3653 Health-related quality of life in the first year post kidney transplantation – a cohort study
#3653 Health-related quality of life in the first year post kidney transplantation – a cohort study Open
Background and Aims For patients suffering from end-stage renal disease, a kidney transplantation is the treatment of choice to improve health-related quality of life (HRQOL). An in-depth understanding of individual factors affecting HRQOL…
View article: #2342 Long term monitoring of torque teno virus load for the detection of infections in kidney transplantation
#2342 Long term monitoring of torque teno virus load for the detection of infections in kidney transplantation Open
Background and Aims Personalized balance of immunosuppression is crucial to prevent organ rejection and infections in kidney transplant recipients. Plasma load of the non-pathogenic and highly prevalent torque teno virus (TTV) has been sug…
View article: #2327 Monitoring of adherence to immunosuppressive drugs by electronic healthcare data in kidney transplant recipients
#2327 Monitoring of adherence to immunosuppressive drugs by electronic healthcare data in kidney transplant recipients Open
Background and Aims Medication non-adherence to immunosuppressive drugs is a major challenge in the management of kidney transplant recipients and a major risk factor for rejection and early graft loss. Utilizing electronic healthcare data…
View article: Self-reported non-adherence to immunosuppressive medication detected by the BAASIS predicts allograft rejections in kidney transplant recipients
Self-reported non-adherence to immunosuppressive medication detected by the BAASIS predicts allograft rejections in kidney transplant recipients Open
Background After kidney transplantation adherence to immunosuppressive medication is crucial for graft survival and its assessment requires valid measurements. The Basel Assessment of Adherence-to Immunosuppressive Medications Scale (BAASI…
View article: Disseminated infection with Candida dubliniensis after ravulizumab and treatment with rezafungin – a case report
Disseminated infection with Candida dubliniensis after ravulizumab and treatment with rezafungin – a case report Open
View article: Cilgavimab and tixagevimab as pre-exposure prophylaxis in vaccine non-responder kidney transplant recipients during a period of prevalent SARS-CoV-2 BA.2 and BA.4/5 variants—a prospective cohort study (RESCUE-TX)
Cilgavimab and tixagevimab as pre-exposure prophylaxis in vaccine non-responder kidney transplant recipients during a period of prevalent SARS-CoV-2 BA.2 and BA.4/5 variants—a prospective cohort study (RESCUE-TX) Open
This study was funded by the Medical University of Vienna and an unrestricted grant from AstraZeneca (ESR-21-21585).
View article: Functional Natural Killer-cell Genetics and Microvascular Inflammation After Kidney Transplantation: An Observational Cohort Study
Functional Natural Killer-cell Genetics and Microvascular Inflammation After Kidney Transplantation: An Observational Cohort Study Open
Background. Recent evidence highlights the pivotal role of natural killer (NK) cells in allograft rejection. Methods. We explored associations of missing self and gene polymorphisms determining the phenotype and/or functionality of NK cell…
View article: #3028 Predictive validity of the Basel Assessment of Adherence to Immunosuppressive Medication Scale (BAASIS©) after renal transplantation
#3028 Predictive validity of the Basel Assessment of Adherence to Immunosuppressive Medication Scale (BAASIS©) after renal transplantation Open
Background and Aims Adherence towards immunosuppressive medication is crucial for allograft survival after renal transplantation. However, its assessment in daily clinical practice remains challenging. The BAASIS© questionnaire, is a valid…
View article: Polyomavirus Nephropathy in ABO Blood Group-Incompatible Kidney Transplantation: Torque Teno Virus and Immunosuppressive Burden as an Approximation to the Problem
Polyomavirus Nephropathy in ABO Blood Group-Incompatible Kidney Transplantation: Torque Teno Virus and Immunosuppressive Burden as an Approximation to the Problem Open
Our data support the assumption that ABOi patients are indeed at higher risk to develop BKPyVAN. A higher TTV load and immunosuppressive burden suggest that intense immunosuppression, rather than an "intrinsic attribute" conferred by ABOi,…
View article: Morphologic and Molecular Features of Antibody-Mediated Transplant Rejection: Pivotal Role of Molecular Injury as an Independent Predictor of Renal Allograft Functional Decline
Morphologic and Molecular Features of Antibody-Mediated Transplant Rejection: Pivotal Role of Molecular Injury as an Independent Predictor of Renal Allograft Functional Decline Open
Current knowledge about the factors correlating with functional decline and subsequent failure of kidney allografts in antibody-mediated rejection (ABMR) is limited. We conducted a cohort study involving 75 renal allograft recipients diagn…
View article: Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation
Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation Open
Antibody-mediated rejection (ABMR) is a leading cause of graft failure. Emerging evidence suggests a significant contribution of natural killer (NK) cells to microvascular inflammation (MVI). We investigated the influence of genetically de…
View article: A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT
A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT Open
Background Immunosuppression after kidney transplantation is mainly guided via plasma tacrolimus trough level, which cannot sufficiently predict allograft rejection and infection. The plasma load of the non-pathogenic and highly prevalent …
View article: Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation Open
Raw microscopy images underlying the publication "Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation"
View article: Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation Open
Raw microscopy images underlying the publication "Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation"
View article: Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation Open
View article: A Multicentre, Patient- and Assessor-blinded, Non-inferiority, Randomised and Controlled Phase Ii Trial to Compare Standard and Torque Teno Virus-guided Immunosuppression in Kidney Transplant Recipients in the First Year After Transplantation: Ttv Guide It
A Multicentre, Patient- and Assessor-blinded, Non-inferiority, Randomised and Controlled Phase Ii Trial to Compare Standard and Torque Teno Virus-guided Immunosuppression in Kidney Transplant Recipients in the First Year After Transplantation: Ttv Guide It Open
Background Immunosuppression after kidney transplantation is mainly guided via plasma tacrolimus trough level, which cannot sufficiently predict allograft rejection and infection. The plasma load of the non-pathogenic and highly prevalent …
View article: Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Kidney Transplant Rejection: Effect on Donor-derived Cell-free DNA and C-X-C Motif Chemokine Ligand 10
Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Kidney Transplant Rejection: Effect on Donor-derived Cell-free DNA and C-X-C Motif Chemokine Ligand 10 Open
Background. Targeting interleukin-6 (IL-6) was shown to counteract donor-specific antibody production and antibody-mediated rejection (AMR) activity. It is not known whether, or to what extent, IL-6 antagonism modulates biomarkers indicati…
View article: Levels of donor‐derived cell‐free DNA and chemokines in BK polyomavirus‐associated nephropathy
Levels of donor‐derived cell‐free DNA and chemokines in BK polyomavirus‐associated nephropathy Open
Background BK polyomavirus‐associated nephropathy (BKPyVAN) carries a risk of irreversible allograft injury. While detection of BK viremia and biopsy assessment are the current diagnostic gold standard, the diagnostic value of biomarkers r…
View article: Early Estimated Glomerular Filtration Rate Trajectories After Kidney Transplant Biopsy as a Surrogate Endpoint for Graft Survival in Late Antibody-Mediated Rejection
Early Estimated Glomerular Filtration Rate Trajectories After Kidney Transplant Biopsy as a Surrogate Endpoint for Graft Survival in Late Antibody-Mediated Rejection Open
Background Late antibody-mediated rejection (ABMR) after kidney transplantation is a major cause of long-term allograft loss with currently no proven treatment strategy. Design for trials testing treatment for late ABMR poses a major chall…
View article: Safety, tolerability, and efficacy of monoclonal CD38 antibody felzartamab in late antibody-mediated renal allograft rejection: study protocol for a phase 2 trial
Safety, tolerability, and efficacy of monoclonal CD38 antibody felzartamab in late antibody-mediated renal allograft rejection: study protocol for a phase 2 trial Open
Background Antibody-mediated rejection (ABMR) is a cardinal cause of renal allograft loss. This rejection type, which may occur at any time after transplantation, commonly presents as a continuum of microvascular inflammation (MVI) culmina…
View article: Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients
Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients Open
EudraCT Identifier: 2021-002927-39.
View article: Diagnostic value of donor‐derived cell‐free DNA to predict antibody‐mediated rejection in donor‐specific antibody‐positive renal allograft recipients
Diagnostic value of donor‐derived cell‐free DNA to predict antibody‐mediated rejection in donor‐specific antibody‐positive renal allograft recipients Open
Circulating donor-specific antibodies (DSA) do not necessarily indicate antibody-mediated rejection (ABMR). Here, we evaluated the diagnostic value of donor-derived cell-free DNA (dd-cfDNA) as an add-on to DSA detection. The study included…
View article: Anti‐interleukin‐6 antibody clazakizumab in late antibody‐mediated kidney transplant rejection: effect on cytochrome P450 drug metabolism
Anti‐interleukin‐6 antibody clazakizumab in late antibody‐mediated kidney transplant rejection: effect on cytochrome P450 drug metabolism Open
Targeting interleukin-6 (IL-6) is a promising strategy to counteract antibody-mediated rejection (ABMR). In inflammatory states, IL-6 antagonism was shown to modulate cytochrome P450 (CYP), but its impact on drug metabolism in ABMR treatme…
View article: Torque Teno Virus Load Is Associated With Subclinical Alloreactivity in Kidney Transplant Recipients: A Prospective Observational Trial
Torque Teno Virus Load Is Associated With Subclinical Alloreactivity in Kidney Transplant Recipients: A Prospective Observational Trial Open
Background. Nonpathogenic torque teno viruses (TTVs) are highly prevalent in transplant recipients and associated with immunosuppression. Studies in kidney transplant patients have proposed assessment of TTV load for risk stratification of…
View article: A Randomized Clinical Trial of Anti–IL-6 Antibody Clazakizumab in Late Antibody-Mediated Kidney Transplant Rejection
A Randomized Clinical Trial of Anti–IL-6 Antibody Clazakizumab in Late Antibody-Mediated Kidney Transplant Rejection Open
Significance Statement There is no proven effective treatment for a major cause of graft failure, late antibody-mediated rejection, but IL-6, a cytokine known to promote B cell immunity, may be a promising therapeutic target. The authors d…
View article: P1643TORQUE TENO VIRUS FOR RISK STRATIFICATION OF SUBCLINICAL GRAFT REJECTION AFTER KIDNEY TRANSPLANTATION- A PROSPECTIVE STUDY
P1643TORQUE TENO VIRUS FOR RISK STRATIFICATION OF SUBCLINICAL GRAFT REJECTION AFTER KIDNEY TRANSPLANTATION- A PROSPECTIVE STUDY Open
Background and Aims Non-invasive monitoring strategies are insufficient to detect patients at risk for subclinical graft rejection after kidney transplantation. The highly prevalent and non-pathogenic Torque Teno virus (TTV) reflects the i…
View article: An author’s reply to the editorial “Torque Teno virus load as a surrogate marker for the net state of immunosuppression: The beneficial side of the virome”
An author’s reply to the editorial “Torque Teno virus load as a surrogate marker for the net state of immunosuppression: The beneficial side of the virome” Open
To the Editor: We are grateful for the editorial by Fernández-Ruiz,1 highlighting the value of Torque Teno virus (TTV) quantification for risk stratification of graft rejection and infection after kidney transplantation. However, we would …