Konstantin Fritz Jendretzky
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View article: Idiopathic inflammatory myopathy associated with Sjögren’s disease: features of a distinct clinical entity
Idiopathic inflammatory myopathy associated with Sjögren’s disease: features of a distinct clinical entity Open
Background Idiopathic inflammatory myopathies (IIM) and Sjögren’s disease (SjD) may coexist, but data on their combined presentation and treatment response remain limited. Methods We retrospectively analyzed 23 patients with biopsy-confirm…
View article: Kappa free light chain concentration in serum is reduced after CD20-depletion with ocrelizumab
Kappa free light chain concentration in serum is reduced after CD20-depletion with ocrelizumab Open
Background Kappa free light chains (KFLC), a byproduct of immunoglobulin (Ig) synthesis by B-lineage cells, can serve as an indicator for inflammatory activity. In multiple sclerosis (MS), especially the intrathecal KFLC production has gai…
View article: Management of disease-modifying therapies in multiple sclerosis and comorbid rheumatoid arthritis
Management of disease-modifying therapies in multiple sclerosis and comorbid rheumatoid arthritis Open
View article: Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy
Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy Open
Objective To evaluate the utility of smartwatch and smartphone‐based activity metrics for assessing disease severity and quality of life in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In the electronic m…
View article: Chronic vertigo and central oculomotor dysfunction with evidence of anti-ITPR1 antibodies
Chronic vertigo and central oculomotor dysfunction with evidence of anti-ITPR1 antibodies Open
View article: Disease-modifying strategies: Targeting protein kinases in multiple sclerosis and other autoimmune disorders
Disease-modifying strategies: Targeting protein kinases in multiple sclerosis and other autoimmune disorders Open
A wide variety of immunomodulatory therapies are already available for the treatment of multiple sclerosis (MS). Through fundamental insights from basic research with a gain of knowledge in the pathological processes underlying MS, the exp…
View article: Prevalence of comorbid autoimmune diseases and antibodies in newly diagnosed multiple sclerosis patients
Prevalence of comorbid autoimmune diseases and antibodies in newly diagnosed multiple sclerosis patients Open
Background Diagnosing multiple sclerosis (MS) is challenging due to diverse symptoms and the absence of specific biomarkers. Concurrent autoimmune diseases (AID) or non-specific antibodies further complicate diagnosis, progression monitori…
View article: Rapid depletion of CD20+ B and T cells following ofatumumab therapy onset
Rapid depletion of CD20+ B and T cells following ofatumumab therapy onset Open
Ofatumumab effectively depletes CD20+ lymphocytes already after the first administration. This depletion affects not only B cells, but also a small proportion of T cells (CD3+CD20+), affirming the hypothesi…
View article: Clinical and paraclinical characteristics of optic neuritis in the context of the McDonald criteria 2017
Clinical and paraclinical characteristics of optic neuritis in the context of the McDonald criteria 2017 Open
View article: Ravulizumab in myasthenic crisis: the first case report
Ravulizumab in myasthenic crisis: the first case report Open
View article: The relevance of NMDA receptor antibody-specific index for diagnosis and prognosis in patients with anti-NMDA receptor encephalitis
The relevance of NMDA receptor antibody-specific index for diagnosis and prognosis in patients with anti-NMDA receptor encephalitis Open
The clinical implications of the presence of anti-N-methyl-D-aspartate receptor (NMDAR)-specific intrathecal immunoglobulin G synthesis and whether it determines the diagnosis of anti-NMDAR encephalitis have not been thoroughly investigate…
View article: Application of diagnostic criteria for optic neuritis
Application of diagnostic criteria for optic neuritis Open
View article: Saliva Free Light Chains in Patients with Neuro-Sjögren
Saliva Free Light Chains in Patients with Neuro-Sjögren Open
Background: Sjögren’s syndrome (SS) is an autoimmune disease characterized by sicca symptoms and various extra-glandular manifestations. The diagnosis of SS requires sicca symptoms, anti-SSA(Ro)-antibody positivity, and/or pathological foc…
View article: Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications
Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications Open
Background: Since the 1990s, transplantations of hematopoietic and mesenchymal stem cells (HSCT and MSCT) and dendritic cell (DCT) have been investigated for the treatment of neurological autoimmune disorders (NADs). With the growing numbe…
View article: Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis
Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis Open
Background: The intrathecal humoral response is the characteristic diagnostic finding in the cerebrospinal fluid (CSF) analysis of patients with multiple sclerosis (MS). Although the average age of MS patients increases, little is known ab…
View article: Kappa Free Light Chains in Cerebrospinal Fluid in Inflammatory and Non-Inflammatory Neurological Diseases
Kappa Free Light Chains in Cerebrospinal Fluid in Inflammatory and Non-Inflammatory Neurological Diseases Open
Background: Oligoclonal bands represent intrathecal immunoglobulin G (IgG) synthesis and play an important role in the diagnosis of multiple sclerosis (MS). Kappa free light chains (KFLC) are increasingly recognized as an additional biomar…
View article: The Influence of the Ventricular-Lumbar Gradient on Cerebrospinal Fluid Analysis in Serial Samples
The Influence of the Ventricular-Lumbar Gradient on Cerebrospinal Fluid Analysis in Serial Samples Open
Background: Cerebrospinal fluid (CSF) samples from patients with non-inflammatory neurological diseases are used for control groups in biomarker studies. Since large amounts of CSF are withdrawn, patients with idiopathic intracranial hyper…
View article: The Increasing Role of Kappa Free Light Chains in the Diagnosis of Multiple Sclerosis
The Increasing Role of Kappa Free Light Chains in the Diagnosis of Multiple Sclerosis Open
Free light chains (FLC) are a promising biomarker to detect intrathecal inflammation in patients with inflammatory central nervous system (CNS) diseases, including multiple sclerosis (MS). The diagnostic use of this biomarker, in particula…
View article: Cerebrospinal Fluid Parameters in Antisense Oligonucleotide-Treated Adult 5q-Spinal Muscular Atrophy Patients
Cerebrospinal Fluid Parameters in Antisense Oligonucleotide-Treated Adult 5q-Spinal Muscular Atrophy Patients Open
Approval of nusinersen, an intrathecally administered antisense oligonucleotide, for the treatment of 5q-spinal muscular atrophy (SMA) marked the beginning of a new therapeutic era in neurological diseases. Changes in routine cerebrospinal…
View article: The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid
The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid Open
Background The determination of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) is an upcoming biomarker for the detection of an intrathecal immunoglobulin synthesis. Since renal function impairment leads to altered serum KFLC …
View article: Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases
Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases Open
Cerebrospinal fluid analysis is an essential part of the diagnostic workup in various neurological disorders. Evidence of an intrathecal immunoglobulin synthesis, as demonstrated by Reiber’s diagram or the more sensitive oligoclonal bands …
View article: The Impact of Immunomodulatory Treatment on Kappa Free Light Chains as Biomarker in Neuroinflammation
The Impact of Immunomodulatory Treatment on Kappa Free Light Chains as Biomarker in Neuroinflammation Open
Background: Kappa free light chains (KFLC) are a promising new biomarker to detect neuroinflammation. Still, the impact of pre-analytical effects on KFLC concentrations was not investigated. Methods: KFLC concentrations were measured in se…
View article: Medical students’ experiences with sexual discrimination and perceptions of equal opportunity: a pilot study in Germany
Medical students’ experiences with sexual discrimination and perceptions of equal opportunity: a pilot study in Germany Open
View article: Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation
Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation Open
Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms. Here, we describe a 69-year-old patient who developed anti-NMDA receptor ence…
View article: Routine Cerebrospinal Fluid Cytology Reveals Unique Inclusions in Macrophages During Treatment With Nusinersen
Routine Cerebrospinal Fluid Cytology Reveals Unique Inclusions in Macrophages During Treatment With Nusinersen Open
Background: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder characterized by degeneration of spinal motor neurons leading to muscular weakness. The antisense oligonucleotide nusinersen was approved…
View article: The Persisting Significance of Oligoclonal Bands in the Dawning Era of Kappa Free Light Chains for the Diagnosis of Multiple Sclerosis
The Persisting Significance of Oligoclonal Bands in the Dawning Era of Kappa Free Light Chains for the Diagnosis of Multiple Sclerosis Open
The latest revision of the McDonald criteria of 2017 considers the evidence of an intrathecal immunoglobulin (IgG) synthesis as a diagnostic criterion for dissemination in time in multiple sclerosis. While the detection of oligoclonal band…