Konstantin Wolf
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View article: Tweaking the NRF2 signaling cascade in human myelogenous leukemia cells by artificial nano-organelles
Tweaking the NRF2 signaling cascade in human myelogenous leukemia cells by artificial nano-organelles Open
NRF2 (nuclear factor erythroid-2-related factor 2) is a key regulator of genes involved in the cell’s protective response to oxidative stress. Upon activation by disturbed redox homeostasis, NRF2 promotes the expression of metabolic enzyme…
View article: Advancing the Design of Artificial Nano-organelles for Targeted Cellular Detoxification of Reactive Oxygen Species
Advancing the Design of Artificial Nano-organelles for Targeted Cellular Detoxification of Reactive Oxygen Species Open
Artificial organelles (AnOs) are in the spotlight as systems to supplement biochemical pathways in cells. While polymersome-based artificial organelles containing enzymes to reduce reactive oxygen species (ROS) are known, applications requ…
View article: Impact of Recombinant Factor VIII and Platelet Interaction on Platelet Functionality and Hemophilia a Treatment
Impact of Recombinant Factor VIII and Platelet Interaction on Platelet Functionality and Hemophilia a Treatment Open
Background: Platelets play an important role throughout the various stages of hemostasis. After vascular injury, platelets become activated in a pro-aggregatory state, and subsequently a subpopulation undergoes a phenotype shift to a pro-c…
View article: Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway
Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway Open
Multiple chemotherapies are proposed to cause cell death in part by increasing the steady-state levels of cellular reactive oxygen species (ROS). However, for most of these drugs exactly how the resultant ROS function and are sensed is poo…