Konstantina M. Stanković
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View article: Comparison of the rates of emergent otologic adverse events following mRNA COVID-19 versus influenza vaccination: a matched cohort analysis
Comparison of the rates of emergent otologic adverse events following mRNA COVID-19 versus influenza vaccination: a matched cohort analysis Open
Background Otologic adverse events (AEs) have been occasionally reported as sequalae of COVID-19 vaccination, although their incidence in comparison with that of preexisting vaccines with high uptake remains unclear. This study compared th…
View article: Correction: Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing
Correction: Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing Open
View article: Clinical trials in otology and neurotology: state of the science
Clinical trials in otology and neurotology: state of the science Open
Objective To evaluate the current state of interventional clinical trials in otology and neurotology. Study design/methods Review of registered clinical trials on ClinicalTrials.gov from January 1st 2019 through May 31st 2025. Intervention…
View article: The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box
The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box Open
Unlike most medical fields, otology has not benefited from the transformative impact of high‐resolution, cellular‐level imaging. The sensorineural cells required for human hearing—located within the cochlea—are just 10–50 µm, placing them …
View article: Scoping review of deep learning research illuminates artificial intelligence chasm in otolaryngology-head and neck surgery
Scoping review of deep learning research illuminates artificial intelligence chasm in otolaryngology-head and neck surgery Open
Clinical validation studies are important to translate artificial intelligence (AI) technology in healthcare but may be underperformed in Otolaryngology - Head & Neck Surgery (OHNS). This scoping review examined deep learning publications …
View article: <i>NF2</i> is Essential for Human Endoderm Development (Adv. Sci. 17/2025)
<i>NF2</i> is Essential for Human Endoderm Development (Adv. Sci. 17/2025) Open
Human Endoderm Development Stem cell differentiation is a critical process in early development and involves the activation and deactivation of genes. The cover art highlights the crucial role of NF2 in regulating endoderm differentiation …
View article: A Plasma Metabolomic Fingerprint of Moderate or Severe Hearing Loss
A Plasma Metabolomic Fingerprint of Moderate or Severe Hearing Loss Open
Background: Disabling hearing loss affects millions of adults world-wide. Metabolomics investigations are comprehensive assessments of an individual’s metabolic processes that could provide insight into biological pathways underlying…
View article: Why Consider Aspirin for the Treatment of Vestibular Schwannoma? A Brief Review and Randomized, Double‐Blind, Placebo‐Controlled Study Proposal
Why Consider Aspirin for the Treatment of Vestibular Schwannoma? A Brief Review and Randomized, Double‐Blind, Placebo‐Controlled Study Proposal Open
Objective The primary objective of this study is to review the evidence for aspirin use to prevent the growth of vestibular schwannomas (VS) and to propose a prospective trial to determine the progression‐free survival of VS patients after…
View article: Editorial: Third window syndrome, volume II
Editorial: Third window syndrome, volume II Open
View article: <i>NF2</i> is Essential for Human Endoderm Development
<i>NF2</i> is Essential for Human Endoderm Development Open
Vertebrate embryogenesis requires the precisely timed specification of 3 germ cell layers— ectoderm, mesoderm, and endoderm— which give rise to tissues and organs in the developing organism. The tumor suppressor gene NF2, moesin‐ezrin‐radi…
View article: Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing
Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing Open
Background Vestibular schwannoma (VS) is an intracranial tumor arising from the Schwann cells of the vestibular nerve and is an important cause of sensorineural hearing loss (SNHL) in humans. The mechanisms underlying this SNHL are incompl…
View article: Angiotensin-Receptor Blockers Prevent Vestibular Schwannoma–Associated Hearing Loss
Angiotensin-Receptor Blockers Prevent Vestibular Schwannoma–Associated Hearing Loss Open
Background & Introduction Vestibular schwannoma (VS) tumors typically present with sensorineural hearing loss (SNHL). Losartan has recently demonstrated prevention of tumor-associated SNHL in a mouse model of VS through suppression of infl…
View article: Editorial: Pathobiological defects in sensorineural hearing loss: from identification to rescue.
Editorial: Pathobiological defects in sensorineural hearing loss: from identification to rescue. Open
View article: Enhanced Tumor Control and Hearing Loss Prevention Achieved with Combined Immune Checkpoint Inhibitor and Anti-VEGF Therapy in Vestibular Schwannoma Model
Enhanced Tumor Control and Hearing Loss Prevention Achieved with Combined Immune Checkpoint Inhibitor and Anti-VEGF Therapy in Vestibular Schwannoma Model Open
Background NF2 -related schwannomatosis ( NF2 -SWN) is a debilitating condition that calls for robust treatment options. The defining feature of NF2 -SWN is the presence of bilateral vestibular schwannomas (VSs), which grow over time and c…
View article: American Academy of Otolaryngology–Head and Neck Surgery (AAO‐HNS) Report on Artificial Intelligence
American Academy of Otolaryngology–Head and Neck Surgery (AAO‐HNS) Report on Artificial Intelligence Open
This report synthesizes the American Academy of Otolaryngology–Head and Neck Surgery (AAO‐HNS) Task Force's guidance on the integration of artificial intelligence (AI) in otolaryngology–head and neck surgery (OHNS). A comprehensive literat…
View article: An In Vitro Oxidative Stress Model of the Human Inner Ear Using Human-Induced Pluripotent Stem Cell-Derived Otic Progenitor Cells
An In Vitro Oxidative Stress Model of the Human Inner Ear Using Human-Induced Pluripotent Stem Cell-Derived Otic Progenitor Cells Open
The inner ear organs responsible for hearing (cochlea) and balance (vestibular system) are susceptible to oxidative stress due to the high metabolic demands of their sensorineural cells. Oxidative stress-induced damage to these cells can c…
View article: Dynamic micro-optical coherence tomography enables structural and metabolic imaging of the mammalian cochlea
Dynamic micro-optical coherence tomography enables structural and metabolic imaging of the mammalian cochlea Open
Sensorineural hearing loss (SNHL) is caused by damage to the mechanosensory hair cells and auditory neurons of the cochlea. The development of imaging tools that can directly visualize or provide functional information about a patient’s co…
View article: Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections
Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections Open
Congenital hearing loss is a common chronic condition affecting children in both developed and developing nations. Viruses correlated with congenital hearing loss include human cytomegalovirus (HCMV) and Zika virus (ZIKV), which causes con…
View article: Correction: Natarajan et al. Noise-Induced Hearing Loss. J. Clin. Med. 2023, 12, 2347
Correction: Natarajan et al. Noise-Induced Hearing Loss. J. Clin. Med. 2023, 12, 2347 Open
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View article: Tinnitus prevalence, associated characteristics, and related healthcare use in the United States: a population-level analysis
Tinnitus prevalence, associated characteristics, and related healthcare use in the United States: a population-level analysis Open
Rich Robbins, Bertarelli Foundation Endowed Professorship.
View article: Genetic Discovery Enabled by A Large Language Model
Genetic Discovery Enabled by A Large Language Model Open
Artificial intelligence (AI) has been used in many areas of medicine, and recently large language models (LLMs) have shown potential utility for clinical applications. However, since we do not know if the use of LLMs can accelerate the pac…
View article: Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma
Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma Open
Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the au…
View article: Current and Emerging Therapies for Chronic Subjective Tinnitus
Current and Emerging Therapies for Chronic Subjective Tinnitus Open
Importance: Chronic subjective tinnitus, the perception of sound without an external source for longer than six months, may be a greatly debilitating condition for some people, and is associated with psychiatric comorbidities and high heal…
View article: Mortui vivos docent: a modern revival of temporal bone plug harvests
Mortui vivos docent: a modern revival of temporal bone plug harvests Open
Human temporal bones (HTBs) are invaluable resources for the study of otologic disorders and for evaluating novel treatment approaches. Given the high costs and technical expertise required to collect and process HTBs, there has been a dec…
View article: miR-431 secreted by human vestibular schwannomas increases the mammalian inner ear’s vulnerability to noise trauma
miR-431 secreted by human vestibular schwannomas increases the mammalian inner ear’s vulnerability to noise trauma Open
Introduction Vestibular schwannoma (VS) is an intracranial tumor that arises on the vestibular branch of cranial nerve VIII and typically presents with sensorineural hearing loss (SNHL). The mechanisms of this SNHL are postulated to involv…
View article: Immune Profiling of Secreted Factors from Human Vestibular Schwannoma Cells and Tumor‐associated Macrophages
Immune Profiling of Secreted Factors from Human Vestibular Schwannoma Cells and Tumor‐associated Macrophages Open
Objectives This study compared the immune‐related secretory capacity of human vestibular schwannoma (VS) and tumor‐assisted macrophages (TAMs) with their normal counterparts (Schwann cells [SC] and peripheral blood monocyte‐derived macroph…
View article: Potential Ototoxicity of Insulin-like Growth Factor 1 Receptor Signaling Inhibitors: An In Silico Drug Repurposing Study of the Regenerating Cochlear Neuron Transcriptome
Potential Ototoxicity of Insulin-like Growth Factor 1 Receptor Signaling Inhibitors: An In Silico Drug Repurposing Study of the Regenerating Cochlear Neuron Transcriptome Open
Spiral ganglion neurons (SGNs) connect cochlear hair cells with higher auditory pathways and their degeneration due to drug toxicity (ototoxicity) contributes to hearing loss. This study aimed to identify drug classes that are negatively c…
View article: Comparative Transcriptomic Analysis of Archival Human Vestibular Schwannoma Tissue from Patients with and without Tinnitus
Comparative Transcriptomic Analysis of Archival Human Vestibular Schwannoma Tissue from Patients with and without Tinnitus Open
Vestibular schwannoma (VS) is an intracranial tumor that commonly presents with tinnitus and hearing loss. To uncover the molecular mechanisms underlying VS-associated tinnitus, we applied next-generation sequencing (Illumina HiSeq) to for…
View article: Noise-Induced Hearing Loss
Noise-Induced Hearing Loss Open
Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural hearing loss, after age-related hearing loss, and affects approximately 5% of the world’s population. NIHL is associated with substantial physical, mental, …
View article: Association of Plasma Metabolomic Biomarkers With Persistent Tinnitus
Association of Plasma Metabolomic Biomarkers With Persistent Tinnitus Open
Importance Persistent tinnitus is common, disabling, and difficult to treat. Objective To evaluate the association between circulating metabolites and persistent tinnitus. Design, Setting, and Participants This was a population-based case-…