Explanipedia

Mechanistic insight into multiple antibody binding to ADAMTS13 in immune thrombotic thrombocytopenic purpura Open

Konstantine Halkidis, Chan Meng, Vikram Gopalakrishna Pillai, Madison Shay, Szumam Liu , et al. · 2024

Thrombotic Thrombocytopenic Purpura in the Setting of Cirrhosis and Baseline Thrombocytopenia Open

Priyanka Venkatesh, Joseph Bennett, Konstantine Halkidis · 2024

The history of thrombotic thrombocytopenic purpura research: a narrative review Open

Konstantine Halkidis, Bernhard Lämmle, X. Long Zheng · 2024

An overview of the major discoveries that have led to our current understanding of TTP reveals the results of collaboration of multiple groups of physicians and scientists through the past century, with additional breakthroughs likely to o…

What is allosteric regulation? Exploring the exceptions that prove the rule! Open

Martin McCullagh, Tonya N. Zeczycki, Chathuri S. Kariyawasam, Clarissa L. Durie, Konstantine Halkidis , et al. · 2024

DATASET: What is allosteric regulation? Exploring the exceptions that prove the rule! Open

Martin McCallagh, Tonya N. Zeczycki, Chathuri S. Kariyawasam, Clarissa L. Durie, Konstantine Halkidis , et al. · 2023

This dataset contains the Kineticscope simulations and schemes used to generated the kinetic populations figure. Kinetiscope is available from https://hinsberg.net/kinetiscope/.

DATASET: What is allosteric regulation? Exploring the exceptions that prove the rule! Open

Martin McCallagh, Tonya N. Zeczycki, Chathuri S. Kariyawasam, Clarissa L. Durie, Konstantine Halkidis , et al. · 2023

This dataset contains the Kineticscope simulations and schemes used to generated the kinetic populations figure. Kinetiscope is available from https://hinsberg.net/kinetiscope/.

HTRS2023.P4.13 Antibody mediated pathophysiology of immune thrombotic thrombocytopenic purpura Open

Konstantine Halkidis, Chan Meng, Szumam Liu, Donald L. Siegel, Walter Englander , et al. · 2023

Mechanisms of Inhibition of Human Monoclonal Antibodies in Immune Thrombotic Thrombocytopenic Purpura Open

Konstantine Halkidis, Chan Meng, Szumam Liu, Leland Mayne, Don L. Siegel , et al. · 2023

Antibody binding to a plasma metalloprotease ADAMTS13 is necessary for the development of immune thrombotic thrombocytopenic purpura (iTTP). Inhibition of ADAMTS13-mediated VWF cleavage by such antibodies clearly plays a role in the pathop…

The Impact of Winter Months on Venous Thromboembolism (VTE) Patients: A Retrospective Analysis of Hospital Outcomes in the United States Open

Michael Styler, Sachi Singhal, Konstantine Halkidis, Parshva Patel, Kristine M Ward , et al. · 2022

ADAMTS13 conformations and mechanism of inhibition in immune thrombotic thrombocytopenic purpura Open

Konstantine Halkidis, X. Long Zheng · 2022

A human monoclonal antibody against the distal carboxyl terminus of ADAMTS‐13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura Open

Konstantine Halkidis, Don L. Siegel, X. Long Zheng · 2021

Plasma levels of S100A8/A9, histone/DNA complexes, and cell‐free DNA predict adverse outcomes of immune thrombotic thrombocytopenic purpura Open

Jingrui Sui, Ruinan Lu, Konstantine Halkidis, Nicole K. Kocher, Wenjing Cao , et al. · 2020

Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura Open

Malay Kumar Basu, Felipe Massicano, Lijia Yu, Konstantine Halkidis, Vikram Gopalakrishna Pillai , et al. · 2020

Background Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal blood disorder, resulting from autoantibodies against ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)…

Longitudinal assessments of plasma ADAMTS13 biomarkers predict recurrence of immune thrombotic thrombocytopenic purpura Open

Jingrui Sui, Wenjing Cao, Konstantine Halkidis, Mohammad S. Abdelgawwad, Nicole K. Kocher , et al. · 2019

Immune thrombotic thrombocytopenic purpura (iTTP) is primarily caused by immunoglobulin G (IgG)–type autoantibodies that bind and inhibit plasma ADAMTS13 activity and/or accelerate its clearance from circulation. Approximately 50% of patie…

Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer Open

Mukta D. Khasnis, Konstantine Halkidis, Anshul Bhardwaj, Michael J. Root · 2016

Structural rearrangements of HIV-1 glycoprotein Env promote viral entry through membrane fusion. Env is a symmetric homotrimer with each protomer composed of surface subunit gp120 and transmembrane subunit gp41. Cellular CD4- and chemokine…

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